Welcome to the CPTAC Community at WikiPathways!
The CPTAC Community highlights pathway content relevant to the Clinical Proteomic Tumor Analysis Consortium (CPTAC). The National Cancer Institute, part of the National Institutes of Health, announced the launch of a Clinical Proteomic Tumor Analysis Consortium in August 2011. CPTAC is a comprehensive and coordinated effort to accelerate the understanding of the molecular basis of cancer through the application of robust, quantitative, proteomic technologies and workflows. The overarching goal of CPTAC is to improve our ability to diagnose, treat and prevent cancer. To achieve this goal in a scientifically rigorous manner, the NCI launched CPTAC to systematically identify proteins that derive from alterations in cancer genomes and related biological processes, and provide this data with accompanying assays and protocols to the public.
Cancer Hallmark Categories
Community Pathways
This community helps to curate 101 pathways:
- 4-hydroxytamoxifen, dexamethasone, and retinoic acids regulation of p27 expression - WP3879 (Homo sapiens)
- ATM signaling in development and disease - WP3878 (Homo sapiens)
- ATM signaling pathway - WP2516 (Homo sapiens)
- ATR signaling - WP3875 (Homo sapiens)
- Altered glycosylation of MUC1 in tumor microenvironment - WP4480 (Homo sapiens)
- Angiogenesis - WP1539 (Homo sapiens)
- Apoptosis - WP254 (Homo sapiens)
- Base excision repair - WP4752 (Homo sapiens)
- Bladder cancer - WP2828 (Homo sapiens)
- Breast cancer pathway - WP4262 (Homo sapiens)
- Cancer immunotherapy by CTLA4 blockade - WP4582 (Homo sapiens)
- Cancer immunotherapy by PD-1 blockade - WP4585 (Homo sapiens)
- Cell cycle - WP179 (Homo sapiens)
- Chemokine signaling pathway - WP3929 (Homo sapiens)
- Chromosomal and microsatellite instability in colorectal cancer - WP4216 (Homo sapiens)
- Clear cell renal cell carcinoma pathways - WP4018 (Homo sapiens)
- Cytokines and inflammatory response - WP530 (Homo sapiens)
- Cytosolic DNA-sensing pathway - WP4655 (Homo sapiens)
- DNA IR-damage and cellular response via ATR - WP4016 (Homo sapiens)
- DNA IR-double strand breaks and cellular response via ATM - WP3959 (Homo sapiens)
- DNA damage response - WP707 (Homo sapiens)
- DNA damage response (only ATM dependent) - WP710 (Homo sapiens)
- DNA mismatch repair - WP531 (Homo sapiens)
- Direct reversal repair - WP4931 (Homo sapiens)
- EGFR tyrosine kinase inhibitor resistance - WP4806 (Homo sapiens)
- EPO receptor signaling - WP581 (Homo sapiens)
- Endometrial cancer - WP4155 (Homo sapiens)
- Epithelial to mesenchymal transition in colorectal cancer - WP4239 (Homo sapiens)
- ErbB signaling pathway - WP673 (Homo sapiens)
- FBXL10 enhancement of MAP/ERK signaling in diffuse large B-cell lymphoma - WP4553 (Homo sapiens)
- Fatty acid beta-oxidation - WP143 (Homo sapiens)
- Fluoropyrimidine activity - WP1601 (Homo sapiens)
- Focal adhesion: PI3K-Akt-mTOR-signaling pathway - WP3932 (Homo sapiens)
- G1 to S cell cycle control - WP45 (Homo sapiens)
- Glycolysis and gluconeogenesis - WP534 (Homo sapiens)
- H19 action Rb-E2F1 signaling and CDK-Beta-catenin activity - WP3969 (Homo sapiens)
- Head and neck squamous cell carcinoma - WP4674 (Homo sapiens)
- Hedgehog signaling pathway - WP4249 (Homo sapiens)
- Hepatitis B infection - WP4666 (Homo sapiens)
- Hepatitis C and hepatocellular carcinoma - WP3646 (Homo sapiens)
- Hepatocyte growth factor receptor signaling - WP313 (Homo sapiens)
- Hereditary leiomyomatosis and renal cell carcinoma pathway - WP4206 (Homo sapiens)
- Hippo-Merlin signaling dysregulation - WP4541 (Homo sapiens)
- IL-1 signaling pathway - WP195 (Homo sapiens)
- IL6 signaling pathway - WP364 (Homo sapiens)
- Imatinib and chronic myeloid leukemia - WP3640 (Homo sapiens)
- Inhibition of exosome biogenesis and secretion by Manumycin A in CRPC cells - WP4301 (Homo sapiens)
- Integrin-mediated cell adhesion - WP185 (Homo sapiens)
- Interactions between immune cells and microRNAs in tumor microenvironment - WP4559 (Homo sapiens)
- Interferon type I signaling pathways - WP585 (Homo sapiens)
- Irinotecan pathway - WP229 (Homo sapiens)
- MAPK signaling pathway - WP382 (Homo sapiens)
- MET in type 1 papillary renal cell carcinoma - WP4205 (Homo sapiens)
- MFAP5 effect on permeability and motility of endothelial cells via cytoskeleton rearrangement - WP4560 (Homo sapiens)
- MFAP5-mediated ovarian cancer cell motility and invasiveness - WP3301 (Homo sapiens)
- Measles virus infection - WP4630 (Homo sapiens)
- Melanoma - WP4685 (Homo sapiens)
- Metabolic reprogramming in colon cancer - WP4290 (Homo sapiens)
- Methylation pathways - WP704 (Homo sapiens)
- MicroRNA for targeting cancer growth and vascularization in glioblastoma - WP3593 (Homo sapiens)
- Model for regulation of MSMP expression in cancer cells and its proangiogenic role in ovarian tumors - WP4397 (Homo sapiens)
- NRF2-ARE regulation - WP4357 (Homo sapiens)
- Neural crest cell migration in cancer - WP4565 (Homo sapiens)
- Non-homologous end joining - WP438 (Homo sapiens)
- Non-small cell lung cancer - WP4255 (Homo sapiens)
- Notch signaling - WP268 (Homo sapiens)
- Notch signaling pathway - WP61 (Homo sapiens)
- Nucleotide excision repair - WP4753 (Homo sapiens)
- One-carbon metabolism - WP241 (Homo sapiens)
- PDGF pathway - WP2526 (Homo sapiens)
- PDGFR-beta pathway - WP3972 (Homo sapiens)
- PI3K-AKT-mTOR signaling pathway and therapeutic opportunities - WP3844 (Homo sapiens)
- Pancreatic adenocarcinoma pathway - WP4263 (Homo sapiens)
- Photodynamic therapy-induced HIF-1 survival signaling - WP3614 (Homo sapiens)
- Photodynamic therapy-induced NF-kB survival signaling - WP3617 (Homo sapiens)
- Ras signaling - WP4223 (Homo sapiens)
- Regulation of Wnt / B-catenin signaling by small molecule compounds - WP3664 (Homo sapiens)
- Regulation of sister chromatid separation at the metaphase-anaphase transition - WP4240 (Homo sapiens)
- Retinoblastoma gene in cancer - WP2446 (Homo sapiens)
- Small cell lung cancer - WP4658 (Homo sapiens)
- TCA cycle nutrient use and invasiveness of ovarian cancer - WP2868 (Homo sapiens)
- TGF-beta receptor signaling - WP560 (Homo sapiens)
- TGF-beta signaling in thyroid cells for epithelial-mesenchymal transition - WP3859 (Homo sapiens)
- TGF-beta signaling pathway - WP366 (Homo sapiens)
- TP53 network - WP1742 (Homo sapiens)
- Target of rapamycin signaling - WP1471 (Homo sapiens)
- Transcriptional activation by NRF2 in response to phytochemicals - WP3 (Homo sapiens)
- Translation inhibitors in chronically activated PDGFRA cells - WP4566 (Homo sapiens)
- Tumor suppressor activity of SMARCB1 - WP4204 (Homo sapiens)
- Type 2 papillary renal cell carcinoma - WP4241 (Homo sapiens)
- Type II interferon signaling - WP619 (Homo sapiens)
- Ultraconserved region 339 modulation of tumor suppressor microRNAs in cancer - WP4284 (Homo sapiens)
- VEGFA-VEGFR2 signaling - WP3888 (Homo sapiens)
- Wnt signaling - WP428 (Homo sapiens)
- Wnt signaling pathway - WP363 (Homo sapiens)
- Wnt/beta-catenin signaling pathway in leukemia - WP3658 (Homo sapiens)
- lncRNA in canonical Wnt signaling and colorectal cancer - WP4258 (Homo sapiens)
- lncRNA-mediated mechanisms of therapeutic resistance - WP3672 (Homo sapiens)
- miRNA regulation of p53 pathway in prostate cancer - WP3982 (Homo sapiens)
- ncRNAs involved in STAT3 signaling in hepatocellular carcinoma - WP4337 (Homo sapiens)
- ncRNAs involved in Wnt signaling in hepatocellular carcinoma - WP4336 (Homo sapiens)
How to Contribute
The CPTAC set of pathways can be edited, updated and added to by anyone using PathVisio. Contact Kristina Hanspers (kristina.hanspers[AT]gladstone.ucsf.edu) if you’re interested in curating, adding or using CPTAC pathways.
Support
This work is supported by The National Cancer Institute.
Authors of Community Pathways
AAR&Co , Kristina Hanspers , Egon Willighagen , Alex Pico , Andika Tan , Anders Riutta , Friederike Ehrhart , Eric Weitz , Maintenance bot , Arturo Manzo-Fontes P D , Martina Summer-Kutmon , Zahra Roudbari , Laurent Winckers , Laur S , James Bjork , Martijn Van Iersel , Marianthi Kalafati , Alexander C. Zambon , Thomas Kelder , Susan Coort , Angelika , Beth Lawlor , Marc Gillespie , Jildau Bouwman , Nuno , Josip , Anam , Finterly Hu , Lars Willighagen , Oneshin , Irene Hemel , Nathan Salomonis , Iliana Campillo Sach , Bruce Conklin , Sergey Dmitriev , Badrul Yahaya , Christine Chichester , Denise Slenter , Sebastien Burel , Ferry Jagers , Jack007 , Ryan Miller , , Marvin Martens , Jonas Hummel , Stan Gaj , Daniela Digles , Vanessa Sousa , Alla Kuchinsky , Asios Olia , Lauren J. Dupuis , Luigi Maiorana , Eric Jaehnig , Michiel Adriaens , Chris Evelo , Patrick Ahles , Adrien Defay , Priyanka K , Licong , Anwesha Bohler , Aaron Caine , Etaglobin , Mark Scott , Kdahlquist , Nick Fidelman , The Herald , Mirk Baranzini , Mark A. Hershberger , Ambar21 , Jonathan Mlius , Unknown , Roelod , Akhilesh Pandey , Axel Weber , NetPath , Joppe014 , Shamith Samarajiwa , Bingo , Elisa Cirillo , Pieter Giesbertz , Chetan1 , Frank , Txr24 , Egoyenechea , Jeff , Garima Thakur , Liling , Ruud Weijer , Linda Rieswijk , Melodyner , Jack Youngren , Nurit Gal , Samuel Sklar , Glenda Nicioli Da Silva , Andra Waagmeester , Jlw9 , Hubert Hug , Agustin Gonzalez-Vicente , Dr.P.R.Sudhakaran , Michael Lieberman , Ericwexler , Sharona Elgavish , Lora Simons , and Mick Eikelhof .