Statin pathway (WP1)

Statins inhibit the endogenous cholesterol production by competitive inhibition of HMG-CoA reductase (HMGCR), the enzyme that catalyzes conversion of HMG-CoA to mevalonate, an early rate-limiting step in cholesterol synthesis. This pathway delineates genes involved in statin pharmacogenomics, including genes involved in mediating the effects of statins on plasma lipoprotein metabolism. Sources: [https://www.pharmgkb.org/pathway/PA2031 PharmGKB] and [http://en.wikipedia.org/wiki/Statin Wikipedia]
last edited

Authors

Cited In

Organism

Mus musculus

Communities

Annotations

Pathway Ontology: hypercholesterolemia pathway statin drug pathway

Disease Ontology: cardiovascular system disease

Participants

Label Type Compact Identifier
Triglycerides Metabolite Ce:CHEBI:17855:T
Phospholipid Metabolite Ce:CHEBI:16247:T
Free FA Metabolite Ce:CHEBI:35366:T
Cholesterol Ester Metabolite Ce:CHEBI:17002:T
Cholesterol Metabolite Ch:HMDB0000067:T
Cholesterol Metabolite Ch:HMDB0000067:T
Statin Metabolite Ce:CHEBI:87631:T
Cholic acid Metabolite Ch:HMDB0000619:T
Acetyl-CoA Metabolite Ch:HMDB0001206:T
Lrp1 GeneProduct L:16971:T
Apoc3 GeneProduct L:11814:T
Apoc2 GeneProduct L:11813:T
Lipc GeneProduct L:15450:T
Cetp GeneProduct L:1071:T
Apoa4 GeneProduct L:11808:T
Dgat1 GeneProduct L:13350:T
Lpl GeneProduct L:16956:T
Scarb1 GeneProduct L:20778:T
Pltp GeneProduct L:18830:T
Ldlr GeneProduct L:16835:T
Abca1 GeneProduct L:11303:T
Cyp7a1 GeneProduct L:13122:T
Hmgcr GeneProduct L:15357:T
Apoa1 GeneProduct L:11806:T
Soat1 GeneProduct L:20652:T
Lcat GeneProduct L:16816:T
Mttp GeneProduct L:17777:T
Apoc1 GeneProduct L:11812:T
Apoe GeneProduct L:11816:T

References