Glutathione metabolism (WP100)

Glutathione is a major antioxidant in all forms of life and an indicator of cellular oxidative stress. Reduction by the GSR enzyme utilizes NADPH as an electron donor. In a reduced form, glutathione is metabolized in multiple ways leading to the biosynthesis of mercapturonate, glutamate, glycine, cysteine and other amino acids. Proteins on this pathway have targeted assays available via the [ CPTAC Assay Portal]
last edited

Authors, MaintBot, Thomas, AlexanderPico, Andra, Egonw, DeSl, and Khanspers

Cited In


Homo sapiens



Pathway Ontology: glutathione metabolic pathway


Label Type Compact Identifier GeneProduct eccode:
g-L-Glutamyl-L-cysteine Metabolite kegg.compound:C00669
GGTLA1 GeneProduct ncbigene:2687
L-Cysteine Metabolite kegg.compound:C00097 GeneProduct eccode:
GGT1 GeneProduct ncbigene:2678
GGTLA1 GeneProduct ncbigene:2687 GeneProduct eccode:
GPX1 GeneProduct ncbigene:2876
GSR GeneProduct ncbigene:2936
Cysteinyl-glycine Metabolite kegg.compound:C01419
ANPEP GeneProduct ncbigene:290 GeneProduct eccode: GeneProduct eccode: GeneProduct eccode:
GSTA1 GeneProduct ncbigene:2938
Glycine Metabolite hmdb:HMDB0000123
GSTM2 GeneProduct ncbigene:2946
GPX2 GeneProduct ncbigene:2877
5-Oxoproline Metabolite kegg.compound:C01879
Glycine Metabolite hmdb:HMDB0000123
GSS GeneProduct ncbigene:2937
GCLC GeneProduct ncbigene:2729
GSTA5 GeneProduct ncbigene:221357
L-Glutamate Metabolite kegg.compound:C00025
NADPH Metabolite hmdb:HMDB0000221
L-Glutamate Metabolite kegg.compound:C00025
(5-L-Glutamyl)-L-amino acid Metabolite kegg.compound:C03740 GeneProduct eccode:
IDH1 GeneProduct ncbigene:3417 GeneProduct eccode:
GGT1 GeneProduct ncbigene:2678 GeneProduct eccode:
GCLM GeneProduct ncbigene:2730 GeneProduct eccode:
GGT1 GeneProduct ncbigene:2678
GPX3 GeneProduct ncbigene:2878
R-S-Mercapturonate Metabolite chebi:47911
L-Amino acid Metabolite kegg.compound:C00151
Bis-g-glutamylcystine Metabolite kegg.compound:C03646 GeneProduct eccode:
R-S-Alanine Metabolite kegg.compound:C05726
GSTT2 GeneProduct ncbigene:2953 GeneProduct eccode: GeneProduct eccode: GeneProduct eccode:
Glutamylcysteinyl-glycylspermidine Metabolite pubchem.compound:440772
NADP+ Metabolite hmdb:HMDB0000217
Glutathione (reduced) Metabolite kegg.compound:C00051
ANPEP GeneProduct ncbigene:290
R-S-Alanylglycine Metabolite kegg.compound:C05729
Acetyl-CoA Metabolite hmdb:HMDB0001206
OPLAH GeneProduct ncbigene:26873 GeneProduct eccode:
R-S-Glutathione Metabolite kegg.compound:C02320 GeneProduct eccode:
GGTLA1 GeneProduct ncbigene:2687
GSTT1 GeneProduct ncbigene:2952
GPX4 GeneProduct ncbigene:2879 GeneProduct eccode:
G6PD GeneProduct ncbigene:2539
Oxidized glutathione Metabolite kegg.compound:C00127 GeneProduct eccode:
GSTM1 GeneProduct ncbigene:2944