Cholesterol biosynthesis (WP103)

Cholesterol is a waxy steroid metabolite found in the cell membranes and transported in the blood plasma of all animals. It is an essential structural component of mammalian cell membranes, where it is required to establish proper membrane permeability and fluidity. In addition, cholesterol is an important component for the manufacture of bile acids, steroid hormones, and several fat-soluble vitamins. Cholesterol is the principal sterol synthesized by animals, but small quantities are synthesized in other eukaryotes, such as plants and fungi. It is almost completely absent among prokaryotes, which include bacteria. Source: [[wikipedia:Cholesterol|Wikipedia]]
last edited


M.Lieberman, MaintBot, N.Mantei, Thomas, Christine Chichester, Egonw, Irenemolina, DeSl, and Eweitz

Cited In


Mus musculus



Pathway Ontology: cholesterol biosynthetic pathway


Label Type Compact Identifier
Nsdhl GeneProduct ncbigene:18194
(S)-2,3-Epoxysqualene Metabolite chebi:15441
Mevalonic acid Metabolite cas:150-97-0
farnesyl pyrophosphate Metabolite cas:13058-04-3
Fdps GeneProduct ncbigene:110196
Hmgcs1 GeneProduct ncbigene:208715
Sc4mol GeneProduct ncbigene:66234
Lathosterol Metabolite cas:80-99-9
Sqle GeneProduct ncbigene:20775
Lanosterin Metabolite cas:79-63-0
Mevalonic acid 5-pyrophosphate Metabolite cas:1492-08-6
Idi1 GeneProduct ncbigene:319554
Mvd GeneProduct ncbigene:192156
Cyp51 GeneProduct ncbigene:13121
Hmgcr GeneProduct ncbigene:15357
7-Dehydrocholesterol Metabolite cas:434-16-2
Dhcr7 GeneProduct ncbigene:13360
isopentenyl pyrophosphate Metabolite cas:358-71-4
Pmvk GeneProduct ncbigene:68603
HMG-CoA Metabolite None
Geranyl-PP Metabolite cas:6699-20-3
Cholesterol Metabolite cas:57-88-5
Fdps GeneProduct ncbigene:110196
Mevalonic acid-5P Metabolite cas:73566-35-5
Squalene Metabolite cas:111-02-4
Sc5d GeneProduct ncbigene:235293
Fdft1 GeneProduct ncbigene:14137
Lss GeneProduct ncbigene:16987
Mvk GeneProduct ncbigene:17855
Acetyl-CoA Metabolite hmdb:HMDB0001206
Dimethylallylpyrophosphate Metabolite cas:358-72-5


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