Cholesterol biosynthesis (WP103)

Cholesterol is a waxy steroid metabolite found in the cell membranes and transported in the blood plasma of all animals. It is an essential structural component of mammalian cell membranes, where it is required to establish proper membrane permeability and fluidity. In addition, cholesterol is an important component for the manufacture of bile acids, steroid hormones, and several fat-soluble vitamins. Cholesterol is the principal sterol synthesized by animals, but small quantities are synthesized in other eukaryotes, such as plants and fungi. It is almost completely absent among prokaryotes, which include bacteria. Source: [[wikipedia:Cholesterol|Wikipedia]]
last edited

Authors

M.Lieberman, MaintBot, N.Mantei, Thomas, Christine Chichester, Egonw, Irenemolina, DeSl, and Eweitz

Cited In

Organism

Mus musculus

Communities

Annotations

Pathway Ontology: cholesterol biosynthetic pathway

Participants

Label Type Compact Identifier
Nsdhl GeneProduct ncbigene:18194
(S)-2,3-Epoxysqualene Metabolite chebi:15441
Mevalonic acid Metabolite cas:150-97-0
farnesyl pyrophosphate Metabolite cas:13058-04-3
Fdps GeneProduct ncbigene:110196
Hmgcs1 GeneProduct ncbigene:208715
Sc4mol GeneProduct ncbigene:66234
Lathosterol Metabolite cas:80-99-9
Sqle GeneProduct ncbigene:20775
Lanosterin Metabolite cas:79-63-0
Mevalonic acid 5-pyrophosphate Metabolite cas:1492-08-6
Idi1 GeneProduct ncbigene:319554
Mvd GeneProduct ncbigene:192156
Cyp51 GeneProduct ncbigene:13121
Hmgcr GeneProduct ncbigene:15357
7-Dehydrocholesterol Metabolite cas:434-16-2
Dhcr7 GeneProduct ncbigene:13360
isopentenyl pyrophosphate Metabolite cas:358-71-4
Pmvk GeneProduct ncbigene:68603
HMG-CoA Metabolite None
Geranyl-PP Metabolite cas:6699-20-3
Cholesterol Metabolite cas:57-88-5
Fdps GeneProduct ncbigene:110196
Mevalonic acid-5P Metabolite cas:73566-35-5
Squalene Metabolite cas:111-02-4
Sc5d GeneProduct ncbigene:235293
Fdft1 GeneProduct ncbigene:14137
Lss GeneProduct ncbigene:16987
Mvk GeneProduct ncbigene:17855
Acetyl-CoA Metabolite hmdb:HMDB0001206
Dimethylallylpyrophosphate Metabolite cas:358-72-5

References

  1. Sagami H, Korenaga T, Ogura K. Geranylgeranyl diphosphate synthase catalyzing the single condensation between isopentenyl diphosphate and farnesyl diphosphate. J Biochem. 1993 Jul;114(1):118–21. PubMed Europe PMC Scholia
  2. Bard M, Bruner DA, Pierson CA, Lees ND, Biermann B, Frye L, et al. Cloning and characterization of ERG25, the Saccharomyces cerevisiae gene encoding C-4 sterol methyl oxidase. Proc Natl Acad Sci U S A. 1996 Jan 9;93(1):186–90. PubMed Europe PMC Scholia
  3. Li L, Kaplan J. Characterization of yeast methyl sterol oxidase (ERG25) and identification of a human homologue. J Biol Chem. 1996 Jul 12;271(28):16927–33. PubMed Europe PMC Scholia
  4. Noshiro M, Aoyama Y, Kawamoto T, Gotoh O, Horiuchi T, Yoshida Y. Structural and evolutionary studies on sterol 14-demethylase P450 (CYP51), the most conserved P450 monooxygenase: I. Structural analyses of the gene and multiple sizes of mRNA. J Biochem. 1997 Dec;122(6):1114–21. PubMed Europe PMC Scholia
  5. Liu XY, Dangel AW, Kelley RI, Zhao W, Denny P, Botcherby M, et al. The gene mutated in bare patches and striated mice encodes a novel 3beta-hydroxysteroid dehydrogenase. Nat Genet. 1999 Jun;22(2):182–7. PubMed Europe PMC Scholia
  6. Gaylor JL. Membrane-bound enzymes of cholesterol synthesis from lanosterol. Biochem Biophys Res Commun. 2002 Apr 19;292(5):1139–46. PubMed Europe PMC Scholia
  7. Ohashi M, Mizushima N, Kabeya Y, Yoshimori T. Localization of mammalian NAD(P)H steroid dehydrogenase-like protein on lipid droplets. J Biol Chem. 2003 Sep 19;278(38):36819–29. PubMed Europe PMC Scholia