Statin pathway (WP1041)

Statins inhibit endogenous cholesterol production by competitive inhibition of HMG-CoA reductase (HMGCR), the enzyme that catalyzes conversion of HMG-CoA to mevalonate, an early rate-limiting step in cholesterol synthesis. This pathway delineates genes involved in statin pharmacogenomics, including genes involved in mediating the effects of statins on plasma lipoprotein metabolism. Sources: [https://www.pharmgkb.org/do/serve?objId=PA2031&objCls=Pathway PharmGKB] and [http://en.wikipedia.org/wiki/Statin Wikipedia]
last edited

Authors

MaintBot, Thomas, AlexanderPico, Ddigles, Mkutmon, Egonw, and Eweitz

Cited In

Organism

Bos taurus

Communities

Annotations

Cell Type Ontology: hepatocyte

Disease Ontology: cardiovascular system disease

Pathway Ontology: statin drug pathway

Participants

Label Type Compact Identifier
Cholesterol Metabolite cas:57-88-5
Cholesterol Metabolite cas:57-88-5
Squalene Metabolite hmdb:HMDB0000256
ABCA1 GeneProduct ensembl:ENSBTAG00000020661
Acyl-CoA Metabolite hmdb:HMDB0003419
ABCG8 GeneProduct ensembl:ENSBTAG00000016366
APOA1 GeneProduct ensembl:ENSBTAG00000002258
APOA4 GeneProduct ensembl:ENSBTAG00000019770
ABCA1 GeneProduct ensembl:ENSBTAG00000020661
APOC2 GeneProduct None
bta-mir-33a GeneProduct ensembl:ENSBTAG00000029975
APOC3 GeneProduct ensembl:ENSBTAG00000012398
APOC1 GeneProduct None
Phospholipid Metabolite kegg.compound:C00865
APOA5 GeneProduct ensembl:ENSBTAG00000019764
DAG Metabolite kegg.compound:C00165
VLDL Metabolite chebi:39027
CYP7A1 GeneProduct ensembl:ENSBTAG00000005287
SCARB1 GeneProduct ensembl:ENSBTAG00000014269
Cholesterol ester Metabolite kegg.compound:C02530
PLTP GeneProduct ensembl:ENSBTAG00000000559
ABCG5 GeneProduct ensembl:ENSBTAG00000016365
APOA2 GeneProduct ensembl:ENSBTAG00000009212
Statin Metabolite chebi:87631
Acetyl-CoA Metabolite hmdb:HMDB0001206
LCAT GeneProduct ensembl:ENSBTAG00000018043
LDLR GeneProduct ensembl:ENSBTAG00000012314
APOB GeneProduct ensembl:ENSBTAG00000008505
IDL Metabolite kegg.compound:C01834
Lipoproteins Metabolite chebi:6495
Cholesterol Metabolite cas:57-88-5
DGAT1 GeneProduct ensembl:ENSBTAG00000026356
LPL GeneProduct ensembl:ENSBTAG00000012855
bta-mir-33b GeneProduct ensembl:ENSBTAG00000036437
Mevalonate Metabolite chebi:25350
HDL Metabolite chebi:39025
SQLE GeneProduct ensembl:ENSBTAG00000005498
LIPC GeneProduct ensembl:ENSBTAG00000005479
Fatty acid Metabolite kegg.compound:C00162
SOAT1 GeneProduct ensembl:ENSBTAG00000004059
APOE GeneProduct ensembl:ENSBTAG00000010123
Cholic Acid Metabolite cas:81-25-4
Cholesterol Metabolite cas:57-88-5
LRP1 GeneProduct ensembl:ENSBTAG00000010830
FDFT1 GeneProduct ensembl:ENSBTAG00000012432
PDIA2 Protein ensembl:ENSBTAG00000016575
LDL Metabolite chebi:39026
ACSS1 Protein ensembl:ENSBTAG00000004281
CETP GeneProduct None
HMGCR GeneProduct ensembl:ENSBTAG00000007840
Triglyceride Metabolite kegg.compound:C00422
MTTP Protein ensembl:ENSBTAG00000011944

References

  1. Wetterau JR, Lin MC, Jamil H. Microsomal triglyceride transfer protein. Biochim Biophys Acta. 1997 Apr 1;1345(2):136–50. PubMed Europe PMC Scholia
  2. Chen H, Ikeda U, Shimpo M, Shimada K. Direct effects of statins on cells primarily involved in atherosclerosis. Hypertens Res. 2000 Mar;23(2):187–92. PubMed Europe PMC Scholia