Cholesterol biosynthesis (WP1070)

Cholesterol is a waxy steroid metabolite found in the cell membranes and transported in the blood plasma of all animals. It is an essential structural component of mammalian cell membranes, where it is required to establish proper membrane permeability and fluidity. In addition, cholesterol is an important component for the manufacture of bile acids, steroid hormones, and several fat-soluble vitamins. Cholesterol is the principal sterol synthesized by animals, but small quantities are synthesized in other eukaryotes, such as plants and fungi. It is almost completely absent among prokaryotes, which include bacteria. Source: [[wikipedia:Cholesterol|Wikipedia]]
last edited


MaintBot, Thomas, Christine Chichester, Mkutmon, Khanspers, Egonw, and Eweitz

Cited In


Bos taurus



Pathway Ontology: cholesterol biosynthetic pathway


Label Type Compact Identifier
NSDHL GeneProduct ensembl:ENSBTAG00000009231
(S)-2,3-Epoxysqualene Metabolite chebi:15441
Mevalonic acid Metabolite cas:150-97-0
farnesyl pyrophosphate Metabolite cas:13058-04-3
FDPS GeneProduct ensembl:ENSBTAG00000003948
HMGCS1 GeneProduct ensembl:ENSBTAG00000011839
SC4MOL GeneProduct ensembl:ENSBTAG00000003068
Lathosterol Metabolite cas:80-99-9
SQLE GeneProduct ensembl:ENSBTAG00000005498
Lanosterin Metabolite cas:79-63-0
Mevalonic acid 5-pyrophosphate Metabolite cas:1492-08-6
IDI1 GeneProduct ensembl:ENSBTAG00000004075
MVD GeneProduct ensembl:ENSBTAG00000012059
CYP51A1 GeneProduct ensembl:ENSBTAG00000001992
HMGCR GeneProduct ensembl:ENSBTAG00000007840
7-Dehydrocholesterol Metabolite cas:434-16-2
DHCR7 GeneProduct ensembl:ENSBTAG00000016465
isopentenyl pyrophosphate Metabolite cas:358-71-4
PMVK GeneProduct ensembl:ENSBTAG00000017819
HMG-CoA Metabolite hmdb:HMDB0001375
Geranyl-PP Metabolite cas:6699-20-3
Cholesterol Metabolite cas:57-88-5
FDPS GeneProduct ensembl:ENSBTAG00000003948
Mevalonic acid-5P Metabolite cas:73566-35-5
Squalene Metabolite cas:111-02-4
SC5DL GeneProduct ensembl:ENSBTAG00000019246
FDFT1 GeneProduct ensembl:ENSBTAG00000012432
LSS GeneProduct ensembl:ENSBTAG00000018936
MVK GeneProduct ensembl:ENSBTAG00000005183
Acetyl-CoA Metabolite cas:72-89-9
Dimethylallylpyrophosphate Metabolite cas:358-72-5