GPCRs, other (WP117)

This pathway was created using the GPCRDB (Horn et al., 1998), (originally at The groupings are based on the GPCR phylogenetic tree available from the GPCRDB and the training sets used by Karchin et al. (Bioinformatics, 2002, pg. 147-159). The labels indicate children and grandchildren of the various classes of GPCRs as described by these references. Proteins on this pathway have targeted assays available via the [ CPTAC Assay Portal]
last edited


Nsalomonis, MaintBot, BruceConklin, Khanspers, AlexanderPico, Egonw, Zari, Mkutmon, and Eweitz

Cited In


Homo sapiens



Pathway Ontology: G protein mediated signaling pathway


Label Type Compact Identifier
EDNRA GeneProduct ncbigene:1909
IL8RB GeneProduct ncbigene:3579
UTS2R GeneProduct ncbigene:2837
GPR18 GeneProduct ncbigene:2841
CELSR3 GeneProduct ncbigene:1951
GPR GeneProduct ncbigene:11245
OR7E35P GeneProduct ncbigene:391632
IL8RA GeneProduct ncbigene:3577
ALG6 GeneProduct ncbigene:29929
GRM8 GeneProduct ncbigene:2918
DRD3 GeneProduct ncbigene:1814
P2RY13 GeneProduct ncbigene:53829
OR7E19P GeneProduct ncbigene:26651
GPR56 GeneProduct ncbigene:9289
HSA10 GeneProduct uniprot:Q9NZP4
LPHN3 GeneProduct ncbigene:23284
GPR83 GeneProduct ncbigene:10888
OR8G1 GeneProduct ncbigene:26494
Q9BYT4 GeneProduct uniprot:Q9BYT4
GPR145 GeneProduct ncbigene:84539
GPR77 GeneProduct ncbigene:27202
OR1F1 GeneProduct ncbigene:4992
GPR135 GeneProduct ncbigene:64582
HSA12 GeneProduct uniprot:Q9NZP3
OR5D3P GeneProduct ncbigene:8594
OR3A4 GeneProduct ensembl:ENSG00000180068
ADORA2A GeneProduct ncbigene:135
CXCR3 GeneProduct ncbigene:2833
GRCA GeneProduct ncbigene:27239
GPR132 GeneProduct ncbigene:29933
HTR1F GeneProduct ncbigene:3355
OR2A20P GeneProduct ncbigene:401428
HRH4 GeneProduct ncbigene:59340
GRM1 GeneProduct ncbigene:2911
GPR88 GeneProduct ncbigene:54112
F2R GeneProduct ncbigene:2149
OR2H1 GeneProduct ncbigene:26716
MASS1 GeneProduct ncbigene:84059
FSHR GeneProduct ncbigene:2492
CHRM2 GeneProduct ncbigene:1129
TAAR3 GeneProduct ncbigene:9288
OR1R1P GeneProduct ncbigene:9596
GNRHR GeneProduct ncbigene:2798
GHRHR GeneProduct ncbigene:2692
OR10A5 GeneProduct ncbigene:144124
ADRA1D GeneProduct ncbigene:146
DRD4 GeneProduct ncbigene:1815
HTR2A GeneProduct ncbigene:3356
OR2F1 GeneProduct ncbigene:26211
OR51A1P GeneProduct ncbigene:26537
HSA8 GeneProduct uniprot:Q9NZP0
HSA3 GeneProduct uniprot:Q9NZP2
P2RY11 GeneProduct ncbigene:5032
CNR1 GeneProduct ncbigene:1268
EDG1 GeneProduct ncbigene:1901
OR2A4 GeneProduct ncbigene:79541
OR5-85 GeneProduct uniprot:P30953
GPR84 GeneProduct ncbigene:53831
CCKBR GeneProduct ncbigene:887
RLN3R1 GeneProduct ncbigene:51289
P47889 GeneProduct uniprot:P47889
OR7E24 GeneProduct ncbigene:26648
OR1G1 GeneProduct ncbigene:8390
GPR73L1 GeneProduct ncbigene:128674
CELSR1 GeneProduct ncbigene:9620
LGR6 GeneProduct ncbigene:59352
GPR17 GeneProduct ncbigene:2840
GPR55 GeneProduct ncbigene:9290
HTR7 GeneProduct ncbigene:3363
Q9H2C7 GeneProduct uniprot:Q9H2C7
EBI2 GeneProduct ncbigene:1880
OR5D3 GeneProduct uniprot:O95220
OR3A1 GeneProduct ncbigene:4994
OR1E3P GeneProduct ncbigene:8389
GRPR GeneProduct ncbigene:2925
SMO GeneProduct ncbigene:6608
OR10A1 GeneProduct ncbigene:144124
FY GeneProduct ncbigene:2532
OR2B6 GeneProduct ncbigene:26212
ADRB2 GeneProduct ncbigene:154
GPR62 GeneProduct ncbigene:118442
OR2M4 GeneProduct ncbigene:26245
OR1N1 GeneProduct ncbigene:138883
CCR2 GeneProduct ncbigene:1231
GPR143 GeneProduct ncbigene:4935
O60411 GeneProduct uniprot:O60411
LTB4R2 GeneProduct ncbigene:56413
CHRM3 GeneProduct ncbigene:1131
GPR133 GeneProduct ncbigene:283383
OR2A9P GeneProduct ensembl:ENSG00000228960
OR10A2 GeneProduct ncbigene:341276
OR7E18P GeneProduct ncbigene:390885
PTGFR GeneProduct ncbigene:5737
LPHN2 GeneProduct ncbigene:23266
NTSR1 GeneProduct ncbigene:4923
HSA1 GeneProduct uniprot:Q9NZP5
Q9UEB1 GeneProduct ensembl:ENSG00000185385
OR2A5 GeneProduct ncbigene:393046
EMR3 GeneProduct ncbigene:84658
GPR116 GeneProduct ncbigene:221395
TAAR5 GeneProduct ncbigene:9038
OR3A3 GeneProduct ncbigene:8392
TAAR2 GeneProduct ncbigene:9287
OR5E1P GeneProduct ensembl:ENSG00000170688
OR1J5 GeneProduct ncbigene:81370
CCR5 GeneProduct ncbigene:1234
VN1R1 GeneProduct ncbigene:57191
ADORA3 GeneProduct ncbigene:140
OR1E1 GeneProduct ncbigene:8387
OR8G2 GeneProduct ncbigene:26492
CELSR2 GeneProduct ncbigene:1952
SSTR2 GeneProduct ncbigene:6752
GPR61 GeneProduct ncbigene:83873
LGR7 GeneProduct ncbigene:59350
EMR2 GeneProduct ncbigene:30817


  1. Horn F, Weare J, Beukers MW, Hörsch S, Bairoch A, Chen W, et al. GPCRDB: an information system for G protein-coupled receptors. Nucleic Acids Res. 1998 Jan 1;26(1):275–9. PubMed Europe PMC Scholia
  2. Karchin R, Karplus K, Haussler D. Classifying G-protein coupled receptors with support vector machines. Bioinformatics. 2002 Jan;18(1):147–59. PubMed Europe PMC Scholia