GPCRs, other (WP117)

This pathway was created using the GPCRDB (Horn et al., 1998), http://www.gpcr.org/7tm/ (originally at http://www.cmbi.kun.nl/7tm/). The groupings are based on the GPCR phylogenetic tree available from the GPCRDB and the training sets used by Karchin et al. (Bioinformatics, 2002, pg. 147-159). The labels indicate children and grandchildren of the various classes of GPCRs as described by these references. Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP117 CPTAC Assay Portal]
last edited

Authors

Nsalomonis, MaintBot, BruceConklin, Khanspers, AlexanderPico, Egonw, Zari, Mkutmon, and Eweitz

Cited In

Organism

Homo sapiens

Communities

Annotations

Pathway Ontology: G protein mediated signaling pathway

Participants

Label Type Compact Identifier
EDNRA GeneProduct ncbigene:1909
IL8RB GeneProduct ncbigene:3579
UTS2R GeneProduct ncbigene:2837
GPR18 GeneProduct ncbigene:2841
CELSR3 GeneProduct ncbigene:1951
GPR GeneProduct ncbigene:11245
OR7E35P GeneProduct ncbigene:391632
IL8RA GeneProduct ncbigene:3577
ALG6 GeneProduct ncbigene:29929
GRM8 GeneProduct ncbigene:2918
DRD3 GeneProduct ncbigene:1814
P2RY13 GeneProduct ncbigene:53829
OR7E19P GeneProduct ncbigene:26651
GPR56 GeneProduct ncbigene:9289
HSA10 GeneProduct uniprot:Q9NZP4
LPHN3 GeneProduct ncbigene:23284
GPR83 GeneProduct ncbigene:10888
OR8G1 GeneProduct ncbigene:26494
Q9BYT4 GeneProduct uniprot:Q9BYT4
GPR145 GeneProduct ncbigene:84539
GPR77 GeneProduct ncbigene:27202
OR1F1 GeneProduct ncbigene:4992
GPR135 GeneProduct ncbigene:64582
HSA12 GeneProduct uniprot:Q9NZP3
OR5D3P GeneProduct ncbigene:8594
OR3A4 GeneProduct ensembl:ENSG00000180068
ADORA2A GeneProduct ncbigene:135
CXCR3 GeneProduct ncbigene:2833
GRCA GeneProduct ncbigene:27239
GPR132 GeneProduct ncbigene:29933
HTR1F GeneProduct ncbigene:3355
OR2A20P GeneProduct ncbigene:401428
HRH4 GeneProduct ncbigene:59340
GRM1 GeneProduct ncbigene:2911
GPR88 GeneProduct ncbigene:54112
F2R GeneProduct ncbigene:2149
OR2H1 GeneProduct ncbigene:26716
MASS1 GeneProduct ncbigene:84059
FSHR GeneProduct ncbigene:2492
CHRM2 GeneProduct ncbigene:1129
TAAR3 GeneProduct ncbigene:9288
OR1R1P GeneProduct ncbigene:9596
GNRHR GeneProduct ncbigene:2798
GHRHR GeneProduct ncbigene:2692
OR10A5 GeneProduct ncbigene:144124
ADRA1D GeneProduct ncbigene:146
DRD4 GeneProduct ncbigene:1815
HTR2A GeneProduct ncbigene:3356
OR2F1 GeneProduct ncbigene:26211
OR51A1P GeneProduct ncbigene:26537
HSA8 GeneProduct uniprot:Q9NZP0
HSA3 GeneProduct uniprot:Q9NZP2
P2RY11 GeneProduct ncbigene:5032
CNR1 GeneProduct ncbigene:1268
EDG1 GeneProduct ncbigene:1901
OR2A4 GeneProduct ncbigene:79541
OR5-85 GeneProduct uniprot:P30953
GPR84 GeneProduct ncbigene:53831
CCKBR GeneProduct ncbigene:887
RLN3R1 GeneProduct ncbigene:51289
P47889 GeneProduct uniprot:P47889
OR7E24 GeneProduct ncbigene:26648
OR1G1 GeneProduct ncbigene:8390
GPR73L1 GeneProduct ncbigene:128674
CELSR1 GeneProduct ncbigene:9620
LGR6 GeneProduct ncbigene:59352
GPR17 GeneProduct ncbigene:2840
GPR55 GeneProduct ncbigene:9290
HTR7 GeneProduct ncbigene:3363
Q9H2C7 GeneProduct uniprot:Q9H2C7
EBI2 GeneProduct ncbigene:1880
OR5D3 GeneProduct uniprot:O95220
OR3A1 GeneProduct ncbigene:4994
OR1E3P GeneProduct ncbigene:8389
GRPR GeneProduct ncbigene:2925
SMO GeneProduct ncbigene:6608
OR10A1 GeneProduct ncbigene:144124
FY GeneProduct ncbigene:2532
OR2B6 GeneProduct ncbigene:26212
ADRB2 GeneProduct ncbigene:154
GPR62 GeneProduct ncbigene:118442
OR2M4 GeneProduct ncbigene:26245
OR1N1 GeneProduct ncbigene:138883
CCR2 GeneProduct ncbigene:1231
GPR143 GeneProduct ncbigene:4935
O60411 GeneProduct uniprot:O60411
LTB4R2 GeneProduct ncbigene:56413
CHRM3 GeneProduct ncbigene:1131
GPR133 GeneProduct ncbigene:283383
OR2A9P GeneProduct ensembl:ENSG00000228960
OR10A2 GeneProduct ncbigene:341276
OR7E18P GeneProduct ncbigene:390885
PTGFR GeneProduct ncbigene:5737
LPHN2 GeneProduct ncbigene:23266
NTSR1 GeneProduct ncbigene:4923
HSA1 GeneProduct uniprot:Q9NZP5
Q9UEB1 GeneProduct ensembl:ENSG00000185385
OR2A5 GeneProduct ncbigene:393046
EMR3 GeneProduct ncbigene:84658
GPR116 GeneProduct ncbigene:221395
TAAR5 GeneProduct ncbigene:9038
OR3A3 GeneProduct ncbigene:8392
TAAR2 GeneProduct ncbigene:9287
OR5E1P GeneProduct ensembl:ENSG00000170688
OR1J5 GeneProduct ncbigene:81370
CCR5 GeneProduct ncbigene:1234
VN1R1 GeneProduct ncbigene:57191
ADORA3 GeneProduct ncbigene:140
OR1E1 GeneProduct ncbigene:8387
OR8G2 GeneProduct ncbigene:26492
CELSR2 GeneProduct ncbigene:1952
SSTR2 GeneProduct ncbigene:6752
GPR61 GeneProduct ncbigene:83873
LGR7 GeneProduct ncbigene:59350
EMR2 GeneProduct ncbigene:30817

References

  1. Horn F, Weare J, Beukers MW, Hörsch S, Bairoch A, Chen W, et al. GPCRDB: an information system for G protein-coupled receptors. Nucleic Acids Res. 1998 Jan 1;26(1):275–9. PubMed Europe PMC Scholia
  2. Karchin R, Karplus K, Haussler D. Classifying G-protein coupled receptors with support vector machines. Bioinformatics. 2002 Jan;18(1):147–59. PubMed Europe PMC Scholia