Osteoclast signaling (WP12)

Signaling pathways involved in osteoclast activation. Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP12 CPTAC Assay Portal]
last edited

Authors

Ehsiao, AlexanderPico, MaintBot, Samuel Sklar, Khanspers, Ddigles, Egonw, Mkutmon, Jessev1993, and Eweitz

Cited In

Organism

Homo sapiens

Communities

Annotations

Pathway Ontology: signaling pathway signaling pathway pertinent to development

Cell Type Ontology: osteoclast

Participants

Label Type Compact Identifier
Ca2+ Metabolite pubchem.compound:271
OPG Protein ncbigene:4982
H+ Metabolite pubchem.compound:1038
PDGFB Protein ncbigene:5155
Pi Metabolite chebi:35780
H+ Metabolite pubchem.compound:1038
TRPV Protein ncbigene:56302
RANK ligand Protein ncbigene:8600
Ca2+ Metabolite pubchem.compound:271
H+ Metabolite pubchem.compound:1038
H+ Metabolite pubchem.compound:1038
AIMP2 GeneProduct ensembl:ENSG00000106305
TRAP Protein ncbigene:54
Cathepsin K Protein ncbigene:1513
IFN-b Protein ncbigene:3456
H+ Metabolite pubchem.compound:1038
Na+/H+ transporter Protein ncbigene:6548
Na+ Metabolite hmdb:HMDB0000588
H+ ATPase Protein ncbigene:9550
MAPK8 GeneProduct ensembl:ENSG00000107643
Na+ Metabolite hmdb:HMDB0000588
RANK Protein ncbigene:8792
TRAP Protein ncbigene:54
Type 1 interferon receptor Protein ncbigene:3454
b3 integrin Protein ncbigene:3690
Cathepsin K Protein ncbigene:1513
OGR1 Protein ncbigene:8111
Osteopontin Protein ncbigene:6696
PDGFB Protein ncbigene:5155

References

  1. Boyle WJ, Simonet WS, Lacey DL. Osteoclast differentiation and activation. Nature. 2003 May 15;423(6937):337–42. PubMed Europe PMC Scholia