EPO receptor signaling (WP1249)

The erythropoietin receptor is a 66 kDa peptide and is a member of the cytokine receptor family. The receptor is tyrosine phosphorylated upon binding by erythropoietin and associates with and activates the tyrosine kinase, JAK2, which activates different intracellular pathways including: Ras/MAP kinase, phosphatidylinositol 3-kinase and STAT transcription factors. The stimulated erythropoietin receptor appears to have a role in erythroid cell survival. Defects in the erythropoietin receptor may produce erythroleukemia and familial erythrocytosis. ''Source: [[wikipedia:Erythropoietin_receptor|Wikipedia]]'' This pathway is based on ScienceSlides.
last edited

Authors

MaintBot, Thomas, Christine Chichester, and Eweitz

Cited In

Organism

Mus musculus

Communities

Annotations

Pathway Ontology: erythropoietin signaling pathway

Participants

Label Type Compact Identifier
Epor GeneProduct ncbigene:13857
Jak2 GeneProduct ncbigene:16452
Src GeneProduct ncbigene:20779
Epor GeneProduct ncbigene:13857
Pik3cg GeneProduct ncbigene:30955
Grb2 GeneProduct ncbigene:14784
Epo GeneProduct ncbigene:13856
Shc1 GeneProduct ncbigene:20416
Pdk1 GeneProduct ncbigene:228026
Stat1 GeneProduct ncbigene:20846
Mapk3 GeneProduct ncbigene:26417
Map2k1 GeneProduct ncbigene:26395
Map2k2 GeneProduct ncbigene:26396
Epo GeneProduct ncbigene:13856
Akt1 GeneProduct ncbigene:11651
Mapk1 GeneProduct ncbigene:26413
Socs1 GeneProduct ncbigene:12703
Stat5b GeneProduct ncbigene:20851
Cish GeneProduct ncbigene:12700
Stat5a GeneProduct ncbigene:20850
Stat3 GeneProduct ncbigene:20848
Stat3 GeneProduct ncbigene:20848
Stat1 GeneProduct ncbigene:20846
Ptprc GeneProduct ncbigene:19264
Ptpru GeneProduct ncbigene:19273
Grb2 GeneProduct ncbigene:14784
Raf1 GeneProduct ncbigene:110157
Sos1 GeneProduct ncbigene:20662
Irs2 GeneProduct ncbigene:384783
Jak2 GeneProduct ncbigene:16452
Irs1 GeneProduct ncbigene:16367
Rasa1 GeneProduct ncbigene:218397
Raf1 GeneProduct ncbigene:110157
Sos1 GeneProduct ncbigene:20662
Rasa1 GeneProduct ncbigene:218397

References

  1. Zhu Y, D’Andrea AD. The molecular physiology of erythropoietin and the erythropoietin receptor. Curr Opin Hematol. 1994 Mar;1(2):113–8. PubMed Europe PMC Scholia
  2. Lacombe C, Mayeux P. The molecular biology of erythropoietin. Nephrol Dial Transplant. 1999;14 Suppl 2:22–8. PubMed Europe PMC Scholia