Type II interferon signaling (IFNG) (WP1253)

Adapted from Raza et al. (2008). This pathway is initiated by IFNG binding to its receptor and a subsequent phosphorylation cascade involving a number of the JAK and STAT family of proteins. Several transcriptionally active complexes are formed (STAT1 homodimer, ISGF3 complex, STAT1:STAT1:IRF9 complex) and the pathway culminates with the transcriptional activation of target genes. [1]
last edited

Authors

MaintBot, Chaodc, AlexanderPico, Khanspers, Ddigles, and Mkutmon

Cited In

Organism

Mus musculus

Communities

Annotations

Pathway Ontology: type II interferon signaling pathway

Cell Type Ontology: macrophage

Participants

Label Type Compact Identifier
Stat2 GeneProduct ncbigene:20847
Ifng GeneProduct ncbigene:15978
Stat1 GeneProduct ncbigene:20846
Sfpi1 GeneProduct ncbigene:20375
OAS1 GeneProduct None
Irf9 GeneProduct ncbigene:16391
Irf8 GeneProduct ncbigene:15900
Irf9 GeneProduct ncbigene:16391
Ifng GeneProduct ncbigene:15978
Jak2 GeneProduct ncbigene:16452
Stat1 GeneProduct ncbigene:20846
Stat1 GeneProduct ncbigene:20846
Ifng GeneProduct ncbigene:15978
Ifng GeneProduct ncbigene:15978
Stat1 GeneProduct ncbigene:20846
Jak1 GeneProduct ncbigene:16451
Stat1 GeneProduct ncbigene:20846
Cxcl9 GeneProduct ncbigene:17329
Stat1 GeneProduct ncbigene:20846
Stat1 GeneProduct ncbigene:20846
Stat2 GeneProduct ncbigene:20847
IFNA GeneProduct ncbigene:111654
Socs1 GeneProduct ncbigene:12703
Cybb GeneProduct ncbigene:13058
Isgf3 GeneProduct None
Ptpn11 GeneProduct ncbigene:19247
Icam1 GeneProduct ncbigene:15894
Irf2 GeneProduct ncbigene:16363
Ifngr2 GeneProduct ncbigene:15980
GBP1 GeneProduct ncbigene:14468
Tap1 GeneProduct ncbigene:21354
Irf8 GeneProduct ncbigene:15900
Ifngr2 GeneProduct ncbigene:15980
Isgf3 GeneProduct None
Ifngr1 GeneProduct ncbigene:15979
Stat1 GeneProduct ncbigene:20846
Jak1 GeneProduct ncbigene:16451
HIST2H4 GeneProduct ncbigene:97122
Ifngr1 GeneProduct ncbigene:15979
Jak1 GeneProduct ncbigene:16451
Ifnb1 GeneProduct ncbigene:15977
Stat1 GeneProduct ncbigene:20846
Jak2 GeneProduct ncbigene:16452
Il1b GeneProduct ncbigene:16176
Jak1 GeneProduct ncbigene:16451
Jak2 GeneProduct ncbigene:16452
Ifngr2 GeneProduct ncbigene:15980
Stat1 GeneProduct ncbigene:20846
Eif2ak2 GeneProduct ncbigene:19106
Stat2 GeneProduct ncbigene:20847
Isg15 GeneProduct ncbigene:100038882
Stat1 GeneProduct ncbigene:20846
Nos2 GeneProduct ncbigene:18126
Stat1 GeneProduct ncbigene:20846
Stat1 GeneProduct ncbigene:20846
Ifngr1 GeneProduct ncbigene:15979
Ifng GeneProduct ncbigene:15978
Stat1 GeneProduct ncbigene:20846
Ifngr1 GeneProduct ncbigene:15979
G1P3 GeneProduct None
Irf1 GeneProduct ncbigene:16362
Cxcl10 GeneProduct ncbigene:15945
Psmb9 GeneProduct ncbigene:16912
Socs3 GeneProduct ncbigene:12702
Irf9 GeneProduct ncbigene:16391
Stat2 GeneProduct ncbigene:20847
Stat1 GeneProduct ncbigene:20846
Stat1 GeneProduct ncbigene:20846
Prkcd GeneProduct ncbigene:18753
Stat1 GeneProduct ncbigene:20846
Irf4 GeneProduct ncbigene:16364
HLA-B GeneProduct None
Ifngr2 GeneProduct ncbigene:15980
Ifit2 GeneProduct ncbigene:15958
Ciita GeneProduct ncbigene:12265
Jak2 GeneProduct ncbigene:16452
Reg1 GeneProduct ncbigene:19692
Irf9 GeneProduct ncbigene:16391
Irf9 GeneProduct ncbigene:16391

References

  1. Raza S, Robertson KA, Lacaze PA, Page D, Enright AJ, Ghazal P, et al. A logic-based diagram of signalling pathways central to macrophage activation. BMC Syst Biol. 2008 Apr 23;2:36. PubMed Europe PMC Scholia