Retinol metabolism (WP1259)

This pathway is about carotenoid metabolism. It is mainly created by the NuGO focusteam on Carotenoid metabolism. Finally it was subject to a text mining workflow which added some additional entities.
last edited

Authors

MaintBot, AlexanderPico, Samuel Sklar, Dingju11, Khanspers, Strand, Thomas, Ddigles, Egonw, and Mkutmon

Cited In

Organism

Mus musculus

Communities

Annotations

Pathway Ontology: retinol metabolic pathway

Participants

Label Type Compact Identifier
Bcmo1 GeneProduct ncbigene:63857
ARAT GeneProduct None
Rbp7 GeneProduct ncbigene:63954
Aldh1a1 GeneProduct ncbigene:11668
Rara GeneProduct ncbigene:19401
Aldh1a2 GeneProduct ncbigene:19378
Abcg8 GeneProduct ncbigene:67470
Rdh12 GeneProduct ncbigene:77974
Rdh5 GeneProduct ncbigene:19682
Dhrs3 GeneProduct ncbigene:20148
Cyp26b1 GeneProduct ncbigene:232174
Npc1l1 GeneProduct ncbigene:237636
Aldh1a3 GeneProduct ncbigene:56847
Aldh1a3 GeneProduct ncbigene:56847
Abcg5 GeneProduct ncbigene:27409
Lpl GeneProduct ncbigene:16956
Cyp2e1 GeneProduct ncbigene:13106
beta-cryptoxanthin Metabolite hmdb:HMDB0002268
Rpe65 GeneProduct ncbigene:19892
Bcdo2 GeneProduct uniprot:Q99NF1
MAPK GeneProduct None
zeaxanthin Metabolite hmdb:HMDB0002789
lutein Metabolite hmdb:HMDB0003233
Scarb1 GeneProduct ncbigene:20778
lycopene Metabolite hmdb:HMDB0003000
Sult2b1 GeneProduct ncbigene:54200
Lrat GeneProduct ncbigene:79235
Rxrb GeneProduct ncbigene:20182
Rdh10 GeneProduct ncbigene:98711
Retsat GeneProduct ncbigene:67442
Rbp1 GeneProduct ncbigene:19659
Rdh12 GeneProduct ncbigene:77974
Rxra GeneProduct ncbigene:20181
Adh4 GeneProduct ncbigene:26876
Vitamin D3 Metabolite hmdb:HMDB0000876
cryptoxanthin Metabolite hmdb:HMDB0002268
Sult1a1 GeneProduct ncbigene:20887
Cyp26a1 GeneProduct ncbigene:13082
Bcmo1 GeneProduct ncbigene:63857
Cd36 GeneProduct ncbigene:12491
violaxanthin Metabolite hmdb:HMDB0003101
Rarg GeneProduct ncbigene:19411
Aldh1a2 GeneProduct ncbigene:19378
canthaxanthin Metabolite hmdb:HMDB0003154
Scarb1 GeneProduct ncbigene:20778
astaxanthin Metabolite hmdb:HMDB0002204
Lrat GeneProduct ncbigene:79235
Aldh1a1 GeneProduct ncbigene:11668
Rdh5 GeneProduct ncbigene:19682
Rdh8 GeneProduct ncbigene:235033
Adh1 GeneProduct ncbigene:11522
Rxrg GeneProduct ncbigene:20183
Crabp2 GeneProduct ncbigene:12904
Crabp1 GeneProduct ncbigene:12903
Rlbp1 GeneProduct ncbigene:19771
alpha-carotene Metabolite hmdb:HMDB0003993
Rbp2 GeneProduct ncbigene:19660
Bcmo1 GeneProduct ncbigene:63857
Rbp4 GeneProduct ncbigene:19662
Rarb GeneProduct ncbigene:218772

References

  1. Khachik F, Beecher GR, Goli MB, Lusby WR, Smith JC Jr. Separation and identification of carotenoids and their oxidation products in the extracts of human plasma. Anal Chem. 1992 Sep 15;64(18):2111–22. PubMed Europe PMC Scholia
  2. Sies H, Stahl W, Sundquist AR. Antioxidant functions of vitamins. Vitamins E and C, beta-carotene, and other carotenoids. Ann N Y Acad Sci. 1992 Sep 30;669:7–20. PubMed Europe PMC Scholia
  3. Micozzi MS, Brown ED, Edwards BK, Bieri JG, Taylor PR, Khachik F, et al. Plasma carotenoid response to chronic intake of selected foods and beta-carotene supplements in men. Am J Clin Nutr. 1992 Jun;55(6):1120–5. PubMed Europe PMC Scholia
  4. Sturgeon SR, Ziegler RG, Brinton LA, Nasca PC, Mallin K, Gridley G. Diet and the risk of vulvar cancer. Ann Epidemiol. 1991 Aug;1(5):427–37. PubMed Europe PMC Scholia
  5. Botilsrud M, Holmberg I, Wathne KO, Blomhoff HK, Norum KR, Blomhoff R. Effect of retinoids and 1,25(OH)2 vitamin D3 bound to their plasma transport proteins on growth and differentiation of HL-60 cells. Scand J Clin Lab Invest. 1990 May;50(3):309–17. PubMed Europe PMC Scholia
  6. Bendich A, Olson JA. Biological actions of carotenoids. FASEB J. 1989 Jun;3(8):1927–32. PubMed Europe PMC Scholia
  7. Hidiroglou M, Williams CJ. Interrelationships among liposoluble vitamins in ruminants. Am J Vet Res. 1986 Aug;47(8):1767–71. PubMed Europe PMC Scholia
  8. Handelman GJ, Dratz EA, Reay CC, van Kuijk JG. Carotenoids in the human macula and whole retina. Invest Ophthalmol Vis Sci. 1988 Jun;29(6):850–5. PubMed Europe PMC Scholia
  9. Olmedilla B, Granado F, Blanco I, Rojas-Hidalgo E. Seasonal and sex-related variations in six serum carotenoids, retinol, and alpha-tocopherol. Am J Clin Nutr. 1994 Jul;60(1):106–10. PubMed Europe PMC Scholia
  10. Yong LC, Forman MR, Beecher GR, Graubard BI, Campbell WS, Reichman ME, et al. Relationship between dietary intake and plasma concentrations of carotenoids in premenopausal women: application of the USDA-NCI carotenoid food-composition database. Am J Clin Nutr. 1994 Aug;60(2):223–30. PubMed Europe PMC Scholia
  11. Vásárhelyi B, Blázovics A, Fehér J. The role of vitamin A analogues and derivatives in the regulation of cell function. Orv Hetil. 1993 Apr 18;134(16):845–8. PubMed Europe PMC Scholia
  12. Satoh T. Fat-soluble vitamins: biotransformation. Nihon Rinsho. 1993 Apr;51(4):865–70. PubMed Europe PMC Scholia
  13. Boosalis MG, Snowdon DA, Tully CL, Gross MD. Acute phase response and plasma carotenoid concentrations in older women: findings from the nun study. Nutrition. 1996;12(7–8):475–8. PubMed Europe PMC Scholia
  14. VandenLangenberg GM, Brady WE, Nebeling LC, Block G, Forman M, Bowen PE, et al. Influence of using different sources of carotenoid data in epidemiologic studies. J Am Diet Assoc. 1996 Dec;96(12):1271–5. PubMed Europe PMC Scholia
  15. Huet F, Semama D, Maingueneau C, Charavel A, Nivelon JL. Vitamin A deficiency and nocturnal vision in teenagers with cystic fibrosis. Eur J Pediatr. 1997 Dec;156(12):949–51. PubMed Europe PMC Scholia
  16. Törmä H, Rollman O, Binderup L, Michaelsson G. Vitamin D analogs affect the uptake and metabolism of retinol by human epidermal keratinocytes in culture. J Investig Dermatol Symp Proc. 1996 Apr;1(1):49–53. PubMed Europe PMC Scholia
  17. Sommerburg O, Keunen JE, Bird AC, van Kuijk FJ. Fruits and vegetables that are sources for lutein and zeaxanthin: the macular pigment in human eyes. Br J Ophthalmol. 1998 Aug;82(8):907–10. PubMed Europe PMC Scholia
  18. Amir H, Karas M, Giat J, Danilenko M, Levy R, Yermiahu T, et al. Lycopene and 1,25-dihydroxyvitamin D3 cooperate in the inhibition of cell cycle progression and induction of differentiation in HL-60 leukemic cells. Nutr Cancer. 1999;33(1):105–12. PubMed Europe PMC Scholia
  19. Johansson S, Melhus H. Vitamin A antagonizes calcium response to vitamin D in man. J Bone Miner Res. 2001 Oct;16(10):1899–905. PubMed Europe PMC Scholia
  20. Balmer JE, Blomhoff R. Gene expression regulation by retinoic acid. J Lipid Res. 2002 Nov;43(11):1773–808. PubMed Europe PMC Scholia
  21. Heber D, Lu Q-Y. Overview of mechanisms of action of lycopene. Exp Biol Med (Maywood). 2002 Nov;227(10):920–3. PubMed Europe PMC Scholia
  22. Ruhl CE, Everhart JE. Relation of elevated serum alanine aminotransferase activity with iron and antioxidant levels in the United States. Gastroenterology. 2003 Jun;124(7):1821–9. PubMed Europe PMC Scholia
  23. Czeczuga-Semeniuk E, Wołczyński S, Markiewicz W. Preliminary identification of carotenoids in malignant and benign neoplasms of the breast and surrounding fatty tissue. Neoplasma. 2003;50(4):280–6. PubMed Europe PMC Scholia