Estrogen signaling (WP1279)

Estrogen receptor refers to a group of receptors which are activated by the hormone 17β-estradiol (estrogen). Two types of estrogen receptor exist: ER which is a member of the nuclear hormone family of intracellular receptors and the estrogen G protein coupled receptor GPR30 (GPER), which is a G-protein coupled receptor. The main function of the estrogen receptor is as a DNA binding transcription factor which regulates gene expression. However the estrogen receptor also has additional functions independent of DNA binding.
last edited

Authors

MaintBot and Khanspers

Cited In

Organism

Rattus norvegicus

Communities

Annotations

Pathway Ontology: estrogen signaling pathway

Participants

Label Type Compact Identifier
Hdac2 GeneProduct ncbigene:84577
Mapk9 GeneProduct ncbigene:50658
ERCC2 GeneProduct ncbigene:308415
Taf7 GeneProduct ncbigene:307485
Taf13 GeneProduct ncbigene:310784
Sin3a GeneProduct ncbigene:363067
Mapk1 GeneProduct ensembl:ENSRNOG00000001849
Estradiol Metabolite hmdb:HMDB0000151
Mnat1 GeneProduct ncbigene:266713
Ccnd1 GeneProduct ncbigene:58919
Gtf2b GeneProduct ncbigene:81673
Bcl2 GeneProduct ncbigene:24224
Polr2i GeneProduct ncbigene:292778
Hdac3 GeneProduct ncbigene:84578
Ercc3 GeneProduct ncbigene:291703
Esr1 GeneProduct ncbigene:24890
Creb1 GeneProduct ncbigene:81646
Estradiol Metabolite hmdb:HMDB0000151
PI3K GeneProduct None
Esr1 GeneProduct ncbigene:24890
Ep300 GeneProduct ncbigene:170915
Ikbkb GeneProduct ensembl:ENSRNOG00000019073
Esr1 GeneProduct ncbigene:24890
N-CoR GeneProduct None
POLR2H GeneProduct ncbigene:498109
Polr2b GeneProduct ncbigene:289561
Estradiol Metabolite hmdb:HMDB0000151
Estradiol Metabolite hmdb:HMDB0000151
Esr1 GeneProduct ncbigene:24890
Prkaca GeneProduct ncbigene:25636
Polr2c GeneProduct ncbigene:361365
TAF12 GeneProduct ncbigene:682902
Cdk7 GeneProduct ncbigene:171150
Jun GeneProduct ncbigene:24516
GSA GeneProduct None
Hdac7 GeneProduct ncbigene:84582
Brca1 GeneProduct ncbigene:497672
Akt1 GeneProduct ncbigene:24185
Gtf2e1 GeneProduct ncbigene:303918
Hdac6 GeneProduct ncbigene:84581
Taf9 GeneProduct ncbigene:373541
Polr2e GeneProduct ncbigene:690966
Gtf2h4 GeneProduct ncbigene:294236
Gtf2h1 GeneProduct ncbigene:361580
Gnb1 GeneProduct ncbigene:24400
Gtf2a2 GeneProduct ncbigene:83828
Gtf2e2 GeneProduct ncbigene:306516
Src GeneProduct ncbigene:83805
Bcl2 GeneProduct ncbigene:24224
LOC367858 GeneProduct ensembl:ENSRNOG00000016611
Gtf2f2 GeneProduct ncbigene:81674
Ikbkg GeneProduct ensembl:ENSRNOG00000037237
Creb1 GeneProduct ncbigene:81646
Esr1 GeneProduct ncbigene:24890
Esr1 GeneProduct ncbigene:24890
Polr2j GeneProduct ncbigene:288588
Sos1 GeneProduct ncbigene:313845
Braf GeneProduct ncbigene:114486
Map2k1 GeneProduct ensembl:ENSRNOG00000010176
Estradiol Metabolite hmdb:HMDB0000151
Esr1 GeneProduct ncbigene:24890
Estradiol Metabolite hmdb:HMDB0000151
Mapk14 GeneProduct ncbigene:81649
Nfkb1 GeneProduct ncbigene:81736
Elk1 GeneProduct ncbigene:314436
Nfkb1 GeneProduct ncbigene:81736
Shc2 GeneProduct ncbigene:314612
Hdac1 GeneProduct ncbigene:297893
Taf6 GeneProduct ncbigene:288533
Estradiol Metabolite hmdb:HMDB0000151
Tbp GeneProduct ncbigene:117526
Estradiol Metabolite hmdb:HMDB0000151
Gtf2a2 GeneProduct ncbigene:83828
POLR2K GeneProduct ncbigene:309224
Crebbp GeneProduct ncbigene:54244
Gper GeneProduct ncbigene:171104
Fos GeneProduct ncbigene:314322
Estradiol Metabolite hmdb:HMDB0000151
Polr2f GeneProduct ncbigene:83503
Grb2 GeneProduct ncbigene:81504
Ilk GeneProduct ncbigene:170922
Gtf2h2 GeneProduct ncbigene:294693
Taf5 GeneProduct ncbigene:294018
Esr1 GeneProduct ncbigene:24890
Cyclic AMP Metabolite hmdb:HMDB0000058
Gngt1 GeneProduct ncbigene:680149
Polr2g GeneProduct ncbigene:117017
HDAC5 GeneProduct ncbigene:84580
Esr1 GeneProduct ncbigene:24890
Hdac8 GeneProduct ncbigene:363481
Tbp GeneProduct ncbigene:117526
Hdac4 GeneProduct ncbigene:363287
Gtf2h3 GeneProduct ncbigene:288651
Polr2a GeneProduct ncbigene:363633
Ccnh GeneProduct ncbigene:84389
Sp1 GeneProduct ncbigene:24790
NP_001101058.1 GeneProduct ensembl:ENSRNOG00000022485

References