EPO receptor signaling (WP1284)

The erythropoietin receptor is a 66 kDa peptide and is a member of the cytokine receptor family. The receptor is tyrosine phosphorylated upon binding by erythropoietin and associates with and activates the tyrosine kinase, JAK2, which activates different intracellular pathways including: Ras/MAP kinase, phosphatidylinositol 3-kinase and STAT transcription factors. The stimulated erythropoietin receptor appears to have a role in erythroid cell survival. Defects in the erythropoietin receptor may produce erythroleukemia and familial erythrocytosis. ''Source: [[wikipedia:Erythropoietin_receptor|Wikipedia]]'' This pathway is based on ScienceSlides.
last edited

Authors

MaintBot, Thomas, Christine Chichester, Mkutmon, and Eweitz

Cited In

Organism

Rattus norvegicus

Communities

Annotations

Pathway Ontology: erythropoietin signaling pathway

Participants

Label Type Compact Identifier
Epor GeneProduct ncbigene:24336
Jak2 GeneProduct ncbigene:24514
Src GeneProduct ncbigene:83805
Epor GeneProduct ncbigene:24336
Pik3cg GeneProduct ensembl:ENSRNOG00000009385
Grb2 GeneProduct ncbigene:81504
Epo GeneProduct ncbigene:24335
Shc1 GeneProduct ncbigene:85385
Pdk1 GeneProduct ncbigene:116551
Stat1 GeneProduct ncbigene:25124
Mapk3 GeneProduct ncbigene:50689
Map2k1 GeneProduct ncbigene:170851
Map2k2 GeneProduct ncbigene:58960
Epo GeneProduct ncbigene:24335
Akt1 GeneProduct ncbigene:24185
Mapk1 GeneProduct ncbigene:116590
Socs1 GeneProduct ncbigene:252971
Stat5b GeneProduct ncbigene:25126
Cish GeneProduct ncbigene:83681
Stat5a GeneProduct ncbigene:24918
Stat3 GeneProduct ncbigene:25125
Stat3 GeneProduct ncbigene:25125
Stat1 GeneProduct ncbigene:25124
Ptprc GeneProduct ncbigene:24699
Ptpru GeneProduct ncbigene:116680
Grb2 GeneProduct ncbigene:81504
Raf1 GeneProduct ncbigene:24703
Sos1 GeneProduct ncbigene:313845
Irs2 GeneProduct ncbigene:29376
Jak2 GeneProduct ncbigene:24514
Irs1 GeneProduct ncbigene:25467
Rasa1 GeneProduct ncbigene:25676
Raf1 GeneProduct ncbigene:24703
Sos1 GeneProduct ncbigene:313845
Rasa1 GeneProduct ncbigene:25676

References

  1. Zhu Y, D’Andrea AD. The molecular physiology of erythropoietin and the erythropoietin receptor. Curr Opin Hematol. 1994 Mar;1(2):113–8. PubMed Europe PMC Scholia
  2. Lacombe C, Mayeux P. The molecular biology of erythropoietin. Nephrol Dial Transplant. 1999;14 Suppl 2:22–8. PubMed Europe PMC Scholia