Type II interferon signaling (IFNG) (WP1289)

Adapted from Raza et al. (2008). This pathway is initiated by IFNG binding to its receptor and a subsequent phosphorylation cascade involving a number of the JAK and STAT family of proteins. Several transcriptionally active complexes are formed (STAT1 homodimer, ISGF3 complex, STAT1:STAT1:IRF9 complex) and the pathway culminates with the transcriptional activation of target genes. [1]
last edited

Authors

MaintBot, Ddigles, and Mkutmon

Cited In

Organism

Rattus norvegicus

Communities

Annotations

Pathway Ontology: type II interferon signaling pathway

Participants

Label Type Compact Identifier
Stat2 GeneProduct ncbigene:288774
Ifng GeneProduct ncbigene:25712
Stat1 GeneProduct ncbigene:25124
Sfpi1 GeneProduct ncbigene:366126
Oas1a GeneProduct ncbigene:192281
Irf9 GeneProduct ncbigene:305896
Irf8 GeneProduct ncbigene:292060
Irf9 GeneProduct ncbigene:305896
Ifng GeneProduct ncbigene:25712
Jak2 GeneProduct ncbigene:24514
Stat1 GeneProduct ncbigene:25124
Stat1 GeneProduct ncbigene:25124
Ifng GeneProduct ncbigene:25712
Ifng GeneProduct ncbigene:25712
Stat1 GeneProduct ncbigene:25124
Jak1 GeneProduct ncbigene:84598
Stat1 GeneProduct ncbigene:25124
Cxcl9 GeneProduct ncbigene:246759
Stat1 GeneProduct ncbigene:25124
Stat1 GeneProduct ncbigene:25124
Stat2 GeneProduct ncbigene:288774
IFNA GeneProduct None
Socs1 GeneProduct ncbigene:252971
Cybb GeneProduct ncbigene:66021
Irf9 GeneProduct ncbigene:305896
Ptpn11 GeneProduct ncbigene:25622
Icam1 GeneProduct ncbigene:25464
Irf2 GeneProduct ncbigene:290749
Ifngr2 GeneProduct ncbigene:360697
Gbp1 GeneProduct ncbigene:304266
Tap1 GeneProduct ncbigene:24811
Irf8 GeneProduct ncbigene:292060
Ifngr2 GeneProduct ncbigene:360697
Irf9 GeneProduct ncbigene:305896
Ifngr1 GeneProduct ncbigene:116465
Stat1 GeneProduct ncbigene:25124
Jak1 GeneProduct ncbigene:84598
HIST2H4 GeneProduct ncbigene:295277
Ifngr1 GeneProduct ncbigene:116465
Jak1 GeneProduct ncbigene:84598
Ifnb1 GeneProduct ncbigene:24481
Stat1 GeneProduct ncbigene:25124
Jak2 GeneProduct ncbigene:24514
Il1b GeneProduct ncbigene:24494
Jak1 GeneProduct ncbigene:84598
Jak2 GeneProduct ncbigene:24514
Ifngr2 GeneProduct ncbigene:360697
Stat1 GeneProduct ncbigene:25124
Eif2ak2 GeneProduct ncbigene:54287
Stat2 GeneProduct ncbigene:288774
G1p2 GeneProduct ncbigene:298693
Stat1 GeneProduct ncbigene:25124
Nos2 GeneProduct ncbigene:24599
Stat1 GeneProduct ncbigene:25124
Stat1 GeneProduct ncbigene:25124
Ifngr1 GeneProduct ncbigene:116465
Ifng GeneProduct ncbigene:25712
Stat1 GeneProduct ncbigene:25124
Ifngr1 GeneProduct ncbigene:116465
G1P3 GeneProduct None
Irf1 GeneProduct ncbigene:24508
Cxcl10 GeneProduct ncbigene:245920
Psmb9 GeneProduct ncbigene:24967
Socs3 GeneProduct ncbigene:89829
Irf9 GeneProduct ncbigene:305896
Stat2 GeneProduct ncbigene:288774
Stat1 GeneProduct ncbigene:25124
Stat1 GeneProduct ncbigene:25124
Prkcd GeneProduct ncbigene:170538
Stat1 GeneProduct ncbigene:25124
Irf4 GeneProduct ncbigene:291100
HLA-B GeneProduct None
Ifngr2 GeneProduct ncbigene:360697
Ifit2 GeneProduct ncbigene:294091
Ciita GeneProduct ncbigene:85483
Jak2 GeneProduct ncbigene:24514
Reg1a GeneProduct ncbigene:24714
Irf9 GeneProduct ncbigene:305896
Irf9 GeneProduct ncbigene:305896

References

  1. Raza S, Robertson KA, Lacaze PA, Page D, Enright AJ, Ghazal P, et al. A logic-based diagram of signalling pathways central to macrophage activation. BMC Syst Biol. 2008 Apr 23;2:36. PubMed Europe PMC Scholia