Matrix metalloproteinases (WP129)

Matrix metalloproteinases (MMPs) are zinc-dependent endopeptidases; other family members are adamalysins, serralysins, and astacins. The MMPs belong to a larger family of proteases known as the metzincin superfamily. Collectively they are capable of degrading all kinds of extracellular matrix proteins, but also can process a number of bioactive molecules. They are known to be involved in the cleavage of cell surface receptors, the release of apoptotic ligands (such as the FAS ligand), and chemokine/cytokine in/activation. MMPs are also thought to play a major role on cell behaviors such as cell proliferation, migration (adhesion/dispersion), differentiation, angiogenesis, apoptosis and host defense. Source: [[wikipedia:Matrix_metalloproteinase|Wikipedia]] Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP129 CPTAC Assay Portal]
last edited

Authors

Kdahlquist, MaintBot, MartijnVanIersel, Khanspers, Thomas, Ddigles, Mkutmon, and Eweitz

Cited In

Organism

Homo sapiens

Communities

Annotations

Pathway Ontology: cell-extracellular matrix signaling pathway protein degradation pathway

Participants

Label Type Compact Identifier
MMP23B GeneProduct ncbigene:8510
MMP27 GeneProduct ncbigene:64066
MMP2 GeneProduct ncbigene:4313
MMP11 GeneProduct ncbigene:4320
MMP15 GeneProduct ncbigene:4324
MMP25 GeneProduct ncbigene:64386
MMP9 GeneProduct ncbigene:4318
MMP3 GeneProduct ncbigene:4314
MMP28 GeneProduct ncbigene:79148
TIMP2 GeneProduct ncbigene:7077
MMP7 GeneProduct ncbigene:4316
MMP10 GeneProduct ncbigene:4319
MMP17 GeneProduct ncbigene:4326
MMP19 GeneProduct ncbigene:4327
BSG GeneProduct ncbigene:682
MMP12 GeneProduct ncbigene:4321
MMP16 GeneProduct ncbigene:4325
TCF20 GeneProduct ncbigene:6942
MMP14 GeneProduct ncbigene:4323
MMP21 GeneProduct ncbigene:118856
MMP20 GeneProduct ncbigene:9313
TIMP1 GeneProduct ncbigene:7076
MMP8 GeneProduct ncbigene:4317
MMP13 GeneProduct ncbigene:4322
TIMP3 GeneProduct ncbigene:7078
MMP24 GeneProduct ncbigene:10893
TNF GeneProduct ncbigene:7124
MMP1 GeneProduct ncbigene:4312
MMP23A GeneProduct ensembl:ENSG00000215914
MMP26 GeneProduct ncbigene:56547
TIMP4 GeneProduct ncbigene:7079

References

  1. Vu TH, Werb Z. Matrix metalloproteinases: effectors of development and normal physiology. Genes Dev. 2000 Sep 1;14(17):2123–33. PubMed Europe PMC Scholia