Apoptosis (WP1290)

Apoptosis is a distinct form of cell death that is functionally and morphologically different from necrosis. Nuclear chromatin condensation, cytoplasmic shrinking, dilated endoplasmic reticulum, and membrane blebbing characterize apoptosis in general. Mitochondria remain morphologically unchanged. In 1972 Kerr et al introduced the concept of apoptosis as a distinct form of "cell-death", and the mechanisms of various apoptotic pathways are still being revealed today.
last edited

Authors

MaintBot, MartijnVanIersel, Khanspers, Christine Chichester, and Mkutmon

Cited In

Organism

Rattus norvegicus

Communities

Annotations

Pathway Ontology: regulatory pathway

Participants

Label Type Compact Identifier
MIR29B1 GeneProduct None
MIR29A GeneProduct None
Pmaip1 GeneProduct ensembl:ENSRNOG00000018770
Casp9 GeneProduct ensembl:ENSRNOG00000012944
Mdm2 GeneProduct ensembl:ENSRNOG00000006304
Bak1 GeneProduct ensembl:ENSRNOG00000000485
Traf3 GeneProduct ensembl:ENSRNOG00000008145
Irf1 GeneProduct ensembl:ENSRNOG00000008144
Nfkb1 GeneProduct ensembl:ENSRNOG00000023258
Fas GeneProduct ensembl:ENSRNOG00000019142
Birc2 GeneProduct ensembl:ENSRNOG00000010602
LOC100360940 GeneProduct ensembl:ENSRNOG00000008548
Akt1 GeneProduct ensembl:ENSRNOG00000028629
Gzmbl1 GeneProduct ensembl:ENSRNOG00000050198
Tnfrsf21 GeneProduct ensembl:ENSRNOG00000011517
Bad GeneProduct ensembl:ENSRNOG00000021147
Nfkbia GeneProduct ensembl:ENSRNOG00000007390
Casp1 GeneProduct ensembl:ENSRNOG00000007372
Ripk1 GeneProduct ensembl:ENSRNOG00000017787
Irf2 GeneProduct ensembl:ENSRNOG00000009824
Nfkbib GeneProduct ensembl:ENSRNOG00000020063
Lta GeneProduct ensembl:ENSRNOG00000000838
Casp4 GeneProduct ensembl:ENSRNOG00000033697
Irf6 GeneProduct ensembl:ENSRNOG00000005082
Casp3 GeneProduct ensembl:ENSRNOG00000010475
Prf1 GeneProduct ensembl:ENSRNOG00000000562
Tnfrsf1a GeneProduct ensembl:ENSRNOG00000031312
Igf1r GeneProduct ensembl:ENSRNOG00000014187
Rela GeneProduct ensembl:ENSRNOG00000030888
Chuk GeneProduct ensembl:ENSRNOG00000022485
Bax GeneProduct ensembl:ENSRNOG00000020876
Apaf1 GeneProduct ensembl:ENSRNOG00000008022
Tnfrsf1b GeneProduct ensembl:ENSRNOG00000016575
CASP10 GeneProduct None
Birc3 GeneProduct ensembl:ENSRNOG00000005731
Bid GeneProduct ensembl:ENSRNOG00000012439
Tnfrsf25 GeneProduct ensembl:ENSRNOG00000021814
Mapk10 GeneProduct ensembl:ENSRNOG00000002079
Traf1 GeneProduct ensembl:ENSRNOG00000048914
Ikbkb GeneProduct ensembl:ENSRNOG00000019073
Irf5 GeneProduct ensembl:ENSRNOG00000007437
Dffa GeneProduct ensembl:ENSRNOG00000013603
AABR07071968.1 GeneProduct ensembl:ENSRNOG00000033924
Nfkbib GeneProduct ensembl:ENSRNOG00000020063
BBC3 GeneProduct None
Irf3 GeneProduct ensembl:ENSRNOG00000043388
Casp2 GeneProduct ensembl:ENSRNOG00000016707
HRK GeneProduct None
Tp73 GeneProduct ensembl:ENSRNOG00000024707
LOC688906 GeneProduct ensembl:ENSRNOG00000005263
Casp7 GeneProduct ensembl:ENSRNOG00000056216
Myc GeneProduct ensembl:ENSRNOG00000004500
LOC103694380 GeneProduct ensembl:ENSRNOG00000000837
Igf2 GeneProduct ensembl:ENSRNOG00000020369
Cradd GeneProduct ensembl:ENSRNOG00000008507
Ikbkg GeneProduct ensembl:ENSRNOG00000060936
Bok GeneProduct ensembl:ENSRNOG00000018214
Traf2 GeneProduct ensembl:ENSRNOG00000006238
Cflar GeneProduct ensembl:ENSRNOG00000012473
Bcl2l2 GeneProduct ensembl:ENSRNOG00000015732
Pik3r1 GeneProduct ensembl:ENSRNOG00000018903
Tradd GeneProduct ensembl:ENSRNOG00000015179
Birc5 GeneProduct ensembl:ENSRNOG00000050819
Igf1 GeneProduct ensembl:ENSRNOG00000004517
Tnfrsf10b GeneProduct ensembl:ENSRNOG00000038483
Jun GeneProduct ensembl:ENSRNOG00000026293
Bnip3l GeneProduct ensembl:ENSRNOG00000009820
Dffb GeneProduct ensembl:ENSRNOG00000025030
Tradd GeneProduct ensembl:ENSRNOG00000015179
Bcl2 GeneProduct ensembl:ENSRNOG00000002791
Tnfrsf1a GeneProduct ensembl:ENSRNOG00000031312
Irf7 GeneProduct ensembl:ENSRNOG00000017414
Rela GeneProduct ensembl:ENSRNOG00000030888
Bcl2l1-ps1 GeneProduct ensembl:ENSRNOG00000018503
Irf4 GeneProduct ensembl:ENSRNOG00000061070
Nfkbie GeneProduct ensembl:ENSRNOG00000019907
Tp53 GeneProduct ensembl:ENSRNOG00000010756
Map2k4 GeneProduct ensembl:ENSRNOG00000003834
Ripk1 GeneProduct ensembl:ENSRNOG00000017787
CDKN2A GeneProduct None
Casp8 GeneProduct ensembl:ENSRNOG00000012331
Xiap GeneProduct ensembl:ENSRNOG00000006967
Bad GeneProduct ensembl:ENSRNOG00000021147
Nfkbia GeneProduct ensembl:ENSRNOG00000007390
Faslg GeneProduct ensembl:ENSRNOG00000002978
Tnfsf10 GeneProduct ensembl:ENSRNOG00000013269
Nfkbie GeneProduct ensembl:ENSRNOG00000019907
LOC100911660 GeneProduct ensembl:ENSRNOG00000047692
Nfkb1 GeneProduct ensembl:ENSRNOG00000023258
Fadd GeneProduct ensembl:ENSRNOG00000047035
MCL1 GeneProduct None
Casp6 GeneProduct ensembl:ENSRNOG00000009508
Bcl2l11 GeneProduct ensembl:ENSRNOG00000016551
LOC100912399 GeneProduct ensembl:ENSRNOG00000013177
Tp63 GeneProduct ensembl:ENSRNOG00000001924
MIR29B2 GeneProduct None

References

  1. Lakin ND, Jackson SP. Regulation of p53 in response to DNA damage. Oncogene. 1999 Dec 13;18(53):7644–55. PubMed Europe PMC Scholia
  2. Mott JL, Kobayashi S, Bronk SF, Gores GJ. mir-29 regulates Mcl-1 protein expression and apoptosis. Oncogene. 2007 Sep 13;26(42):6133–40. PubMed Europe PMC Scholia
  3. Bose I, Ghosh B. The p53-MDM2 network: from oscillations to apoptosis. J Biosci. 2007 Aug;32(5):991–7. PubMed Europe PMC Scholia
  4. Park S-Y, Lee JH, Ha M, Nam J-W, Kim VN. miR-29 miRNAs activate p53 by targeting p85 alpha and CDC42. Nat Struct Mol Biol. 2009 Jan;16(1):23–9. PubMed Europe PMC Scholia