Nod-like receptor (NLR) signaling pathway (WP1294)

Mammalian cells have evolved a set of specialized pattern recognition-molecules (PRMs) to detect conserved molecular motifs present on pathogens known as pathogen-associated-molecular-patterns (PAMPs). NLR proteins (alternatively named NBD-LRR or CATERPILLER) represent one subclass of PRMs that have recently attracted much attention. Their cytoplasmic location differs from the classical PRMs which are mostly membrane spanning receptors (such as the Toll-like-receptors (TLRs) or lectins) and accordingly NLRs were proposed to be activated mainly by intracellular bacterial pathogens.
last edited

Authors

MaintBot, Ddigles, AlexanderPico, and Eweitz

Cited In

Organism

Rattus norvegicus

Communities

Annotations

Pathway Ontology: NOD-like receptor signaling pathway

Participants

Label Type Compact Identifier
ERBB2IP GeneProduct ncbigene:365662
DAMPS Metabolite None
Chuk GeneProduct ncbigene:309361
CARD GeneProduct None
CARD GeneProduct None
Ikbkg GeneProduct ncbigene:309295
TriDAP Metabolite None
CARD GeneProduct None
RelA GeneProduct ncbigene:309165
MAPK GeneProduct None
Mapk8 GeneProduct ncbigene:116554
Ephb2 GeneProduct ncbigene:313633
Map3k7 GeneProduct ncbigene:313121
CARD GeneProduct None
MDP Metabolite None
Ikbkb GeneProduct ncbigene:84351
Cd40 GeneProduct ncbigene:171369

References

  1. Meylan E, Tschopp J, Karin M. Intracellular pattern recognition receptors in the host response. Nature. 2006 Jul 6;442(7098):39–44. PubMed Europe PMC Scholia
  2. Fritz JH, Ferrero RL, Philpott DJ, Girardin SE. Nod-like proteins in immunity, inflammation and disease. Nat Immunol. 2006 Dec;7(12):1250–7. PubMed Europe PMC Scholia
  3. Mariathasan S, Monack DM. Inflammasome adaptors and sensors: intracellular regulators of infection and inflammation. Nat Rev Immunol. 2007 Jan;7(1):31–40. PubMed Europe PMC Scholia
  4. Carneiro LAM, Magalhaes JG, Tattoli I, Philpott DJ, Travassos LH. Nod-like proteins in inflammation and disease. J Pathol. 2008 Jan;214(2):136–48. PubMed Europe PMC Scholia
  5. Kufer TA. Signal transduction pathways used by NLR-type innate immune receptors. Mol Biosyst. 2008 May;4(5):380–6. PubMed Europe PMC Scholia
  6. Shaw MH, Reimer T, Kim Y-G, Nuñez G. NOD-like receptors (NLRs): bona fide intracellular microbial sensors. Curr Opin Immunol. 2008 Aug;20(4):377–82. PubMed Europe PMC Scholia