Nod-like receptor (NLR) signaling pathway (WP1294)

Mammalian cells have evolved a set of specialized pattern recognition-molecules (PRMs) to detect conserved molecular motifs present on pathogens known as pathogen-associated-molecular-patterns (PAMPs). NLR proteins (alternatively named NBD-LRR or CATERPILLER) represent one subclass of PRMs that have recently attracted much attention. Their cytoplasmic location differs from the classical PRMs which are mostly membrane spanning receptors (such as the Toll-like-receptors (TLRs) or lectins) and accordingly NLRs were proposed to be activated mainly by intracellular bacterial pathogens.
last edited


MaintBot, Ddigles, AlexanderPico, and Eweitz

Cited In


Rattus norvegicus



Pathway Ontology: NOD-like receptor signaling pathway


Label Type Compact Identifier
ERBB2IP GeneProduct ncbigene:365662
DAMPS Metabolite None
Chuk GeneProduct ncbigene:309361
CARD GeneProduct None
CARD GeneProduct None
Ikbkg GeneProduct ncbigene:309295
TriDAP Metabolite None
CARD GeneProduct None
RelA GeneProduct ncbigene:309165
MAPK GeneProduct None
Mapk8 GeneProduct ncbigene:116554
Ephb2 GeneProduct ncbigene:313633
Map3k7 GeneProduct ncbigene:313121
CARD GeneProduct None
MDP Metabolite None
Ikbkb GeneProduct ncbigene:84351
Cd40 GeneProduct ncbigene:171369


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