Estrogen metabolism (WP1302)

last edited

Authors

MaintBot, Khanspers, Mkutmon, and Susan

Cited In

Organism

Rattus norvegicus

Communities

Annotations

Pathway Ontology: steroid metabolic pathway

Participants

Label Type Compact Identifier
2-Hydroxyestrone Metabolite hmdb:HMDB0000343
Comt GeneProduct ensembl:ENSRNOG00000001889
Ugt1a3 GeneProduct ensembl:ENSRNOG00000018740
Cyp1a2 GeneProduct ensembl:ENSRNOG00000016173
Estrone Metabolite hmdb:HMDB0000145
Ugt1a1 GeneProduct ncbigene:24861
Ugt1a1 GeneProduct ncbigene:24861
4-hydroxyestradiol Metabolite None
Ste GeneProduct ensembl:ENSRNOG00000001957
Comt GeneProduct ensembl:ENSRNOG00000001889
Ugt1a3 GeneProduct ensembl:ENSRNOG00000018740
4-Methoxyestradiol-3-glucuronide Metabolite None
Sult1a1 GeneProduct ensembl:ENSRNOG00000019342
2-Methoxyestradiol-3-glucuronide Metabolite None
Arse GeneProduct ensembl:ENSRNOG00000028350
UGT2B7 GeneProduct None
2-Hydroxyestradiol Metabolite hmdb:HMDB0000338
4-Hydroxyestradiol-3-glucuronide Metabolite None
Estradiol sulfate Metabolite None
Estrone sulfate Metabolite hmdb:HMDB0001425
2-hydroxyestradiol-3-glucuronide Metabolite None
Ugt1a3 GeneProduct ensembl:ENSRNOG00000018740
Nqo1 GeneProduct ensembl:ENSRNOG00000012772
Oxygen Metabolite hmdb:HMDB0001377
CYP3A4 GeneProduct None
Oxygen Metabolite hmdb:HMDB0001377
Ugt1a1 GeneProduct ncbigene:24861
Estradiol Metabolite None
Cyp1a1 GeneProduct ensembl:ENSRNOG00000019500
Sult1a1 GeneProduct ensembl:ENSRNOG00000019342
Oxygen Metabolite hmdb:HMDB0001377
Oxygen Metabolite hmdb:HMDB0001377
2-hydroxy-estradiol-2-glucuronide Metabolite None
UGT2B7 GeneProduct None
Ugt1a3 GeneProduct ensembl:ENSRNOG00000018740
4-hydroxyestrone Metabolite None
Estrone-2,3-quinone Metabolite pubchem.compound:148381
16a-Hydroxyestrone Metabolite hmdb:HMDB0000335
Comt GeneProduct ensembl:ENSRNOG00000001889
2-Methoxyestrone 3-glucuronide Metabolite hmdb:HMDB0004482
Estradiol-3,4-semiquinone Metabolite None
2-Hydroxyestrone-3-glucuronide Metabolite None
4-hydroxyestrone-3-glucuronide Metabolite None
Estrone-2,3-semiquinone Metabolite None
UGT1A9 GeneProduct ncbigene:396552
Estradiol-3-glucuronide Metabolite hmdb:HMDB0006224
Superoxide Metabolite hmdb:HMDB0002168
Ugt1a3 GeneProduct ensembl:ENSRNOG00000018740
Ugt1a1 GeneProduct ncbigene:24861
Ugt1a3 GeneProduct ensembl:ENSRNOG00000018740
Comt GeneProduct ensembl:ENSRNOG00000001889
UGT1A9 GeneProduct ncbigene:396552
Ugt1a3 GeneProduct ensembl:ENSRNOG00000018740
4-Methoxyestrone-3-glucuronide Metabolite None
Cyp1a2 GeneProduct ensembl:ENSRNOG00000016173
Superoxide Metabolite hmdb:HMDB0002168
GSTA1 GeneProduct None
UGT2B7 GeneProduct None
CYP3A4 GeneProduct None
2-Methoxyestradiol Metabolite hmdb:HMDB0000405
Ugt1a1 GeneProduct ncbigene:24861
2-hydroxy-estradiol-sulfate Metabolite None
Estradiol-3,4-quinone Metabolite None
Superoxide Metabolite hmdb:HMDB0002168
Estradiol-2,3-semiquinone Metabolite None
Estradiol-17-glucuronide Metabolite None
Ugt1a3 GeneProduct ensembl:ENSRNOG00000018740
Ugt1a3 GeneProduct ensembl:ENSRNOG00000018740
Ugt1a2 GeneProduct ncbigene:396527
Estrone-17-glucuronide Metabolite hmdb:HMDB0004483
GSTM1 GeneProduct ncbigene:24423
Sts GeneProduct ncbigene:24800
Estrone-3,4-semiquinone Metabolite None
Cyp1a1 GeneProduct ensembl:ENSRNOG00000019500
4-hydroxy-estradiol-4-glucuronide Metabolite None
Estradiol-2,3-quinone Metabolite None
4-hydroxy-estradiol-sulfate Metabolite None
4-Methoxyestradiol Metabolite hmdb:HMDB0000405
Nqo1 GeneProduct ensembl:ENSRNOG00000012772
Estrone-3-glucuronide Metabolite hmdb:HMDB0004483
ARSD GeneProduct None
Ugt1a3 GeneProduct ensembl:ENSRNOG00000018740
Ugt1a1 GeneProduct ncbigene:24861
UGT2B7 GeneProduct None
Sult1a1 GeneProduct ensembl:ENSRNOG00000019342
Superoxide Metabolite hmdb:HMDB0002168
2-Methoxyestrone Metabolite hmdb:HMDB0000010
4-Methoxyestrone Metabolite None
Estrone-3,4-quinone Metabolite pubchem.compound:114862
Cyp1b1 GeneProduct ensembl:ENSRNOG00000040287

References

  1. Cavalieri EL, Stack DE, Devanesan PD, Todorovic R, Dwivedy I, Higginbotham S, et al. Molecular origin of cancer: catechol estrogen-3,4-quinones as endogenous tumor initiators. Proc Natl Acad Sci U S A. 1997 Sep 30;94(20):10937–42. PubMed Europe PMC Scholia
  2. Raftogianis R, Creveling C, Weinshilboum R, Weisz J. Estrogen metabolism by conjugation. J Natl Cancer Inst Monogr. 2000;(27):113–24. PubMed Europe PMC Scholia
  3. Lakhani NJ, Sarkar MA, Venitz J, Figg WD. 2-Methoxyestradiol, a promising anticancer agent. Pharmacotherapy. 2003 Feb;23(2):165–72. PubMed Europe PMC Scholia
  4. Bianco NR, Perry G, Smith MA, Templeton DJ, Montano MM. Functional implications of antiestrogen induction of quinone reductase: inhibition of estrogen-induced deoxyribonucleic acid damage. Mol Endocrinol. 2003 Jul;17(7):1344–55. PubMed Europe PMC Scholia
  5. Rogan EG, Badawi AF, Devanesan PD, Meza JL, Edney JA, West WW, et al. Relative imbalances in estrogen metabolism and conjugation in breast tissue of women with carcinoma: potential biomarkers of susceptibility to cancer. Carcinogenesis. 2003 Apr;24(4):697–702. PubMed Europe PMC Scholia
  6. Guillemette C, Bélanger A, Lépine J. Metabolic inactivation of estrogens in breast tissue by UDP-glucuronosyltransferase enzymes: an overview. Breast Cancer Res. 2004;6(6):246–54. PubMed Europe PMC Scholia
  7. Abel EL, Lyon RP, Bammler TK, Verlinde CLMJ, Lau SS, Monks TJ, et al. Estradiol metabolites as isoform-specific inhibitors of human glutathione S-transferases. Chem Biol Interact. 2004 Dec 30;151(1):21–32. PubMed Europe PMC Scholia
  8. Shatalova EG, Walther SE, Favorova OO, Rebbeck TR, Blanchard RL. Genetic polymorphisms in human SULT1A1 and UGT1A1 genes associate with breast tumor characteristics: a case-series study. Breast Cancer Res. 2005;7(6):R909-21. PubMed Europe PMC Scholia