Apoptosis (WP1351)

Apoptosis is a distinct form of cell death that is functionally and morphologically different from necrosis. Nuclear chromatin condensation, cytoplasmic shrinking, dilated endoplasmic reticulum, and membrane blebbing characterize apoptosis in general. Mitochondria remain morphologically unchanged. In 1972 Kerr et al introduced the concept of apoptosis as a distinct form of "cell-death", and the mechanisms of various apoptotic pathways are still being revealed today.
last edited

Authors

MaintBot, MartijnVanIersel, Khanspers, Mkutmon, and LWackers

Cited In

Organism

Danio rerio

Communities

Annotations

Pathway Ontology: regulatory pathway

Participants

Label Type Compact Identifier
MIR29B1 GeneProduct None
MIR29A GeneProduct None
PMAIP1 GeneProduct None
casp9 GeneProduct ensembl:ENSDARG00000004325
mdm2 GeneProduct ensembl:ENSDARG00000033443
BAK1 GeneProduct None
traf3 GeneProduct ensembl:ENSDARG00000022000
txndc15 GeneProduct ensembl:ENSDARG00000043249
nfkb1 GeneProduct ensembl:ENSDARG00000105261
fas GeneProduct ensembl:ENSDARG00000043586
birc2 GeneProduct ensembl:ENSDARG00000044619
diabloa GeneProduct ensembl:ENSDARG00000104172
akt1 GeneProduct ensembl:ENSDARG00000099657
si:ch211-165b19.5 GeneProduct ensembl:ENSDARG00000055986
tnfrsf21 GeneProduct ensembl:ENSDARG00000001807
bada GeneProduct ensembl:ENSDARG00000087993
nfkbiab GeneProduct ensembl:ENSDARG00000007693
zgc:171731 GeneProduct ensembl:ENSDARG00000014657
ripk1l GeneProduct ensembl:ENSDARG00000006677
irf2a GeneProduct ensembl:ENSDARG00000007387
nfkbib GeneProduct ensembl:ENSDARG00000030087
tnfb GeneProduct ensembl:ENSDARG00000013598
zgc:171731 GeneProduct ensembl:ENSDARG00000014657
irf6 GeneProduct ensembl:ENSDARG00000101986
casp3b GeneProduct ensembl:ENSDARG00000055045
prf1.2 GeneProduct ensembl:ENSDARG00000021444
tnfrsf1a GeneProduct ensembl:ENSDARG00000018569
igf1ra GeneProduct ensembl:ENSDARG00000027423
rela GeneProduct ensembl:ENSDARG00000098696
chuk GeneProduct ensembl:ENSDARG00000011662
BX511080.1 GeneProduct ensembl:ENSDARG00000089995
apaf1 GeneProduct ensembl:ENSDARG00000021239
tnfrsf1b GeneProduct ensembl:ENSDARG00000070165
CASP10 GeneProduct None
birc2 GeneProduct ensembl:ENSDARG00000044619
BID GeneProduct None
si:ch211-112c15.8 GeneProduct ensembl:ENSDARG00000089868
mapk10 GeneProduct ensembl:ENSDARG00000102730
traf1 GeneProduct ensembl:ENSDARG00000069482
ikbkb GeneProduct ensembl:ENSDARG00000079123
irf5 GeneProduct ensembl:ENSDARG00000045681
dffa GeneProduct ensembl:ENSDARG00000055770
cycsa GeneProduct ensembl:ENSDARG00000095636
nfkbib GeneProduct ensembl:ENSDARG00000030087
BBC3 GeneProduct None
irf3 GeneProduct ensembl:ENSDARG00000076251
casp2 GeneProduct ensembl:ENSDARG00000062052
HRK GeneProduct None
tp73 GeneProduct ensembl:ENSDARG00000017953
scaf11 GeneProduct ensembl:ENSDARG00000045885
casp7 GeneProduct ensembl:ENSDARG00000091836
myca GeneProduct ensembl:ENSDARG00000045695
tnfb GeneProduct ensembl:ENSDARG00000013598
igf2a GeneProduct ensembl:ENSDARG00000018643
cradd GeneProduct ensembl:ENSDARG00000028192
ikbkg GeneProduct ensembl:ENSDARG00000017037
boka GeneProduct ensembl:ENSDARG00000052129
unm_sa808 GeneProduct ensembl:ENSDARG00000078378
cflara GeneProduct ensembl:ENSDARG00000055966
BCL2L2 GeneProduct None
pik3r1 GeneProduct ensembl:ENSDARG00000038524
tradd GeneProduct ensembl:ENSDARG00000036057
birc5a GeneProduct ensembl:ENSDARG00000075621
igf1 GeneProduct ensembl:ENSDARG00000094132
tnfrsfa GeneProduct ensembl:ENSDARG00000004451
jun GeneProduct ensembl:ENSDARG00000043531
bnip3la GeneProduct ensembl:ENSDARG00000025468
dffb GeneProduct ensembl:ENSDARG00000009748
tradd GeneProduct ensembl:ENSDARG00000036057
bcl2a GeneProduct ensembl:ENSDARG00000094704
tnfrsf1a GeneProduct ensembl:ENSDARG00000018569
irf7 GeneProduct ensembl:ENSDARG00000045661
rela GeneProduct ensembl:ENSDARG00000098696
bcl2l1 GeneProduct ensembl:ENSDARG00000008434
irf4b GeneProduct ensembl:ENSDARG00000055374
nfkbie GeneProduct ensembl:ENSDARG00000068367
tp53 GeneProduct ensembl:ENSDARG00000035559
map2k4a GeneProduct ensembl:ENSDARG00000063583
ripk1l GeneProduct ensembl:ENSDARG00000006677
cdkn2a/b GeneProduct ensembl:ENSDARG00000037262
casp8l1 GeneProduct ensembl:ENSDARG00000058341
xiap GeneProduct ensembl:ENSDARG00000016143
bada GeneProduct ensembl:ENSDARG00000087993
nfkbiab GeneProduct ensembl:ENSDARG00000007693
faslg GeneProduct ensembl:ENSDARG00000098913
tnfsf10 GeneProduct ensembl:ENSDARG00000057241
nfkbie GeneProduct ensembl:ENSDARG00000068367
hells GeneProduct ensembl:ENSDARG00000057738
nfkb1 GeneProduct ensembl:ENSDARG00000105261
fadd GeneProduct ensembl:ENSDARG00000103021
mcl1a GeneProduct ensembl:ENSDARG00000009779
casp6 GeneProduct ensembl:ENSDARG00000093405
BCL2L11 GeneProduct None
map3k1 GeneProduct ensembl:ENSDARG00000098405
tp63 GeneProduct ensembl:ENSDARG00000044356
MIR29B2 GeneProduct None

References

  1. Lakin ND, Jackson SP. Regulation of p53 in response to DNA damage. Oncogene. 1999 Dec 13;18(53):7644–55. PubMed Europe PMC Scholia
  2. Mott JL, Kobayashi S, Bronk SF, Gores GJ. mir-29 regulates Mcl-1 protein expression and apoptosis. Oncogene. 2007 Sep 13;26(42):6133–40. PubMed Europe PMC Scholia
  3. Bose I, Ghosh B. The p53-MDM2 network: from oscillations to apoptosis. J Biosci. 2007 Aug;32(5):991–7. PubMed Europe PMC Scholia
  4. Park S-Y, Lee JH, Ha M, Nam J-W, Kim VN. miR-29 miRNAs activate p53 by targeting p85 alpha and CDC42. Nat Struct Mol Biol. 2009 Jan;16(1):23–9. PubMed Europe PMC Scholia