Cholesterol biosynthesis (WP1387)

Cholesterol is a waxy steroid metabolite found in the cell membranes and transported in the blood plasma of all animals. It is an essential structural component of mammalian cell membranes, where it is required to establish proper membrane permeability and fluidity. In addition, cholesterol is an important component for the manufacture of bile acids, steroid hormones, and several fat-soluble vitamins. Cholesterol is the principal sterol synthesized by animals, but small quantities are synthesized in other eukaryotes, such as plants and fungi. It is almost completely absent among prokaryotes, which include bacteria. Source: [[wikipedia:Cholesterol|Wikipedia]]
last edited

Authors

MaintBot, Thomas, Christine Chichester, Mkutmon, Egonw, and Eweitz

Cited In

Organism

Danio rerio

Communities

Annotations

Pathway Ontology: cholesterol biosynthetic pathway

Participants

Label Type Compact Identifier
nsdhl GeneProduct ncbigene:550369
(S)-2,3-Epoxysqualene Metabolite chebi:15441
Mevalonic acid Metabolite cas:150-97-0
farnesyl pyrophosphate Metabolite cas:13058-04-3
fdps GeneProduct ncbigene:552997
hmgcs1 GeneProduct ncbigene:394060
msmol GeneProduct ncbigene:406662
Lathosterol Metabolite cas:80-99-9
sqlea GeneProduct ncbigene:799528
Lanosterin Metabolite cas:79-63-0
Mevalonic acid 5-pyrophosphate Metabolite cas:1492-08-6
idi1 GeneProduct ncbigene:553513
mvd GeneProduct ncbigene:492781
cyp51 GeneProduct ncbigene:414331
hmgcra GeneProduct ensembl:ENSDARG00000052734
7-Dehydrocholesterol Metabolite cas:434-16-2
dhcr7 GeneProduct ncbigene:378446
isopentenyl pyrophosphate Metabolite cas:358-71-4
pmvk GeneProduct ncbigene:100003383
HMG-CoA Metabolite None
Geranyl-PP Metabolite cas:6699-20-3
Cholesterol Metabolite cas:57-88-5
fdps GeneProduct ncbigene:552997
Mevalonic acid-5P Metabolite cas:73566-35-5
Squalene Metabolite cas:111-02-4
sc5d GeneProduct ncbigene:447891
fdft1 GeneProduct ncbigene:571911
lss GeneProduct ncbigene:795400
mvk GeneProduct ncbigene:492477
Acetyl-CoA Metabolite None
Dimethylallylpyrophosphate Metabolite cas:358-72-5
hmgcrb GeneProduct ensembl:ENSDARG00000059301

References

  1. Sagami H, Korenaga T, Ogura K. Geranylgeranyl diphosphate synthase catalyzing the single condensation between isopentenyl diphosphate and farnesyl diphosphate. J Biochem. 1993 Jul;114(1):118–21. PubMed Europe PMC Scholia
  2. Bard M, Bruner DA, Pierson CA, Lees ND, Biermann B, Frye L, et al. Cloning and characterization of ERG25, the Saccharomyces cerevisiae gene encoding C-4 sterol methyl oxidase. Proc Natl Acad Sci U S A. 1996 Jan 9;93(1):186–90. PubMed Europe PMC Scholia
  3. Li L, Kaplan J. Characterization of yeast methyl sterol oxidase (ERG25) and identification of a human homologue. J Biol Chem. 1996 Jul 12;271(28):16927–33. PubMed Europe PMC Scholia
  4. Noshiro M, Aoyama Y, Kawamoto T, Gotoh O, Horiuchi T, Yoshida Y. Structural and evolutionary studies on sterol 14-demethylase P450 (CYP51), the most conserved P450 monooxygenase: I. Structural analyses of the gene and multiple sizes of mRNA. J Biochem. 1997 Dec;122(6):1114–21. PubMed Europe PMC Scholia
  5. Liu XY, Dangel AW, Kelley RI, Zhao W, Denny P, Botcherby M, et al. The gene mutated in bare patches and striated mice encodes a novel 3beta-hydroxysteroid dehydrogenase. Nat Genet. 1999 Jun;22(2):182–7. PubMed Europe PMC Scholia
  6. Gaylor JL. Membrane-bound enzymes of cholesterol synthesis from lanosterol. Biochem Biophys Res Commun. 2002 Apr 19;292(5):1139–46. PubMed Europe PMC Scholia
  7. Ohashi M, Mizushima N, Kabeya Y, Yoshimori T. Localization of mammalian NAD(P)H steroid dehydrogenase-like protein on lipid droplets. J Biol Chem. 2003 Sep 19;278(38):36819–29. PubMed Europe PMC Scholia