Cholesterol biosynthesis (WP1387)

Cholesterol is a waxy steroid metabolite found in the cell membranes and transported in the blood plasma of all animals. It is an essential structural component of mammalian cell membranes, where it is required to establish proper membrane permeability and fluidity. In addition, cholesterol is an important component for the manufacture of bile acids, steroid hormones, and several fat-soluble vitamins. Cholesterol is the principal sterol synthesized by animals, but small quantities are synthesized in other eukaryotes, such as plants and fungi. It is almost completely absent among prokaryotes, which include bacteria. Source: [[wikipedia:Cholesterol|Wikipedia]]
last edited


MaintBot, Thomas, Christine Chichester, Mkutmon, Egonw, and Eweitz

Cited In


Danio rerio



Pathway Ontology: cholesterol biosynthetic pathway


Label Type Compact Identifier
nsdhl GeneProduct ncbigene:550369
(S)-2,3-Epoxysqualene Metabolite chebi:15441
Mevalonic acid Metabolite cas:150-97-0
farnesyl pyrophosphate Metabolite cas:13058-04-3
fdps GeneProduct ncbigene:552997
hmgcs1 GeneProduct ncbigene:394060
msmol GeneProduct ncbigene:406662
Lathosterol Metabolite cas:80-99-9
sqlea GeneProduct ncbigene:799528
Lanosterin Metabolite cas:79-63-0
Mevalonic acid 5-pyrophosphate Metabolite cas:1492-08-6
idi1 GeneProduct ncbigene:553513
mvd GeneProduct ncbigene:492781
cyp51 GeneProduct ncbigene:414331
hmgcra GeneProduct ensembl:ENSDARG00000052734
7-Dehydrocholesterol Metabolite cas:434-16-2
dhcr7 GeneProduct ncbigene:378446
isopentenyl pyrophosphate Metabolite cas:358-71-4
pmvk GeneProduct ncbigene:100003383
HMG-CoA Metabolite None
Geranyl-PP Metabolite cas:6699-20-3
Cholesterol Metabolite cas:57-88-5
fdps GeneProduct ncbigene:552997
Mevalonic acid-5P Metabolite cas:73566-35-5
Squalene Metabolite cas:111-02-4
sc5d GeneProduct ncbigene:447891
fdft1 GeneProduct ncbigene:571911
lss GeneProduct ncbigene:795400
mvk GeneProduct ncbigene:492477
Acetyl-CoA Metabolite None
Dimethylallylpyrophosphate Metabolite cas:358-72-5
hmgcrb GeneProduct ensembl:ENSDARG00000059301


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