Myometrial relaxation and contraction pathways (WP140)

This pathway illustrates signaling networks implicated in uterine muscle contraction at labor and quiescence throughout gestation (pregnancy). The muscle of the uterus, responsible for contractile activity is the myometrium. Genes in this pathway are either transcribed in myometrial muscle cells or act upon the myometrium to regulate contraction. The left half of this pathway illustrates pathways of myometrial relaxation that are active throughout normal gestation. These signaling events act to suppress coordinated contractions to prevent the early onset of labor at term, largely via activation of the adenylyl-cyclase thrhough G-protein coupled receptors. On the right side of this pathway are signaling componets involved in the activation of uterine contractions at labor, in particular, activation of calcium mobilization via Oxytocin mediated binding to the Oxytocin G-protein coupled receptor. Additional genes implicated in this pathway, based on microarray expression profiling of gestation, term and postpartum of term mice are also included (e.g., Guca2b, Rdc1, Edg2) have also been included. For a detailed description of this pathway see: http://genomebiology.com/2005/6/2/R12.
last edited

Authors

Nsalomonis, MaintBot, Thomas, Khanspers, Elisa, Mkutmon, L Dupuis, and Eweitz

Cited In

Organism

Rattus norvegicus

Communities

Annotations

Pathway Ontology: signaling pathway

Cell Type Ontology: smooth muscle cell

Participants

Label Type Compact Identifier
Ramp1 GeneProduct ensembl:ENSRNOG00000019926
Igfbp6 GeneProduct ensembl:ENSRNOG00000010977
Gng13 GeneProduct ensembl:ENSRNOG00000039350
RGS11 GeneProduct None
Prkcz GeneProduct ensembl:ENSRNOG00000015480
Adcy5 GeneProduct ensembl:ENSRNOG00000002229
Ryr1 GeneProduct ensembl:ENSRNOG00000020557
Atp2a3 GeneProduct ensembl:ENSRNOG00000017912
Atf4 GeneProduct ensembl:ENSRNOG00000017801
GUCY2E GeneProduct None
Prkar2b GeneProduct ensembl:ENSRNOG00000009079
Prkcg GeneProduct ensembl:ENSRNOG00000054371
Adcy2 GeneProduct ensembl:ENSRNOG00000032150
Prkce GeneProduct ensembl:ENSRNOG00000015603
Igfbp5 GeneProduct ensembl:ENSRNOG00000017206
Grk4 GeneProduct ensembl:ENSRNOG00000011847
Gnb3 GeneProduct ensembl:ENSRNOG00000015541
Gng3 GeneProduct ensembl:ENSRNOG00000019570
Pkib GeneProduct ensembl:ENSRNOG00000000811
Fos GeneProduct ensembl:ENSRNOG00000008015
Grk5 GeneProduct ensembl:ENSRNOG00000011439
Oxtr GeneProduct ensembl:ENSRNOG00000005806
Mylk2 GeneProduct ensembl:ENSRNOG00000008235
Gng12 GeneProduct ensembl:ENSRNOG00000050231
Rgs2 GeneProduct ensembl:ENSRNOG00000003687
Gng2 GeneProduct ensembl:ENSRNOG00000048980
Rgs6 GeneProduct ensembl:ENSRNOG00000008082
Jun GeneProduct ensembl:ENSRNOG00000026293
Adcy3 GeneProduct ensembl:ENSRNOG00000003999
Gng7 GeneProduct ensembl:ENSRNOG00000019857
Prkacb GeneProduct ensembl:ENSRNOG00000004978
Atf6b GeneProduct ensembl:ENSRNOG00000000431
ACTA2 GeneProduct None
Ramp2 GeneProduct ensembl:ENSRNOG00000020415
Gpr182 GeneProduct ensembl:ENSRNOG00000004311
Calca GeneProduct ensembl:ENSRNOG00000011130
Adcy8 GeneProduct ensembl:ENSRNOG00000004890
Adcy1 GeneProduct ensembl:ENSRNOG00000059479
Arrb2 GeneProduct ensembl:ENSRNOG00000019308
Atf1 GeneProduct ensembl:ENSRNOG00000061088
Nos1 GeneProduct ensembl:ENSRNOG00000001130
Grk5 GeneProduct ensembl:ENSRNOG00000011439
Rgs17 GeneProduct ensembl:ENSRNOG00000018690
Prkch GeneProduct ensembl:ENSRNOG00000004873
Ryr2 GeneProduct ensembl:ENSRNOG00000017060
Rgs18 GeneProduct ensembl:ENSRNOG00000003959
Ywhab GeneProduct ensembl:ENSRNOG00000010945
Il6 GeneProduct ensembl:ENSRNOG00000010278
Grk6 GeneProduct ensembl:ENSRNOG00000014615
Crcp GeneProduct ensembl:ENSRNOG00000000901
Rxfp1 GeneProduct ensembl:ENSRNOG00000024120
Cnn1 GeneProduct ensembl:ENSRNOG00000027736
Ywhah GeneProduct ensembl:ENSRNOG00000055471
Camk2g GeneProduct ensembl:ENSRNOG00000009783
Rgs7 GeneProduct ensembl:ENSRNOG00000021984
Myl4 GeneProduct ensembl:ENSRNOG00000050675
Rgs1 GeneProduct ensembl:ENSRNOG00000003895
Prkcb GeneProduct ensembl:ENSRNOG00000012061
Mylk2 GeneProduct ensembl:ENSRNOG00000008235
Lpar1 GeneProduct ensembl:ENSRNOG00000013656
Ramp3 GeneProduct ensembl:ENSRNOG00000053766
Camk2d GeneProduct ensembl:ENSRNOG00000011589
Prkcq GeneProduct ensembl:ENSRNOG00000019057
Nos3 GeneProduct ensembl:ENSRNOG00000009348
Cald1 GeneProduct ensembl:ENSRNOG00000010233
Gsto1 GeneProduct ensembl:ENSRNOG00000028746
Crh GeneProduct ensembl:ENSRNOG00000012703
ATP Metabolite cas:1927-31-7
Prkca GeneProduct ensembl:ENSRNOG00000003491
YWHAZ GeneProduct None
Grk4 GeneProduct ensembl:ENSRNOG00000011847
Cnn2 GeneProduct ensembl:ENSRNOG00000043044
Prkar2a GeneProduct ensembl:ENSRNOG00000020284
Arrb2 GeneProduct ensembl:ENSRNOG00000019308
Gnb2 GeneProduct ensembl:ENSRNOG00000001409
Gng11 GeneProduct ensembl:ENSRNOG00000047914
Oxtr GeneProduct ensembl:ENSRNOG00000005806
Igfbp4 GeneProduct ensembl:ENSRNOG00000010635
Ryr3 GeneProduct ensembl:ENSRNOG00000006645
Rgs10 GeneProduct ensembl:ENSRNOG00000042592
Dgkz GeneProduct ensembl:ENSRNOG00000017737
Rgs5 GeneProduct ensembl:ENSRNOG00000002730
Atp2a2 GeneProduct ensembl:ENSRNOG00000001285
Igfbp2 GeneProduct ensembl:ENSRNOG00000016957
Rgs20 GeneProduct ensembl:ENSRNOG00000008100
Gnaq GeneProduct ensembl:ENSRNOG00000014183
Cyclic AMP Metabolite hmdb:HMDB0000058
Gnb5 GeneProduct ensembl:ENSRNOG00000047799
Ywhae GeneProduct ensembl:ENSRNOG00000005290
Oxt GeneProduct ensembl:ENSRNOG00000021225
Prkar1a GeneProduct ensembl:ENSRNOG00000049876
Rgs9 GeneProduct ensembl:ENSRNOG00000003800
Sfn GeneProduct ensembl:ENSRNOG00000033153
Adcy7 GeneProduct ensembl:ENSRNOG00000014776
Atf5 GeneProduct ensembl:ENSRNOG00000020060
Plcg2 GeneProduct ensembl:ENSRNOG00000051986
Il1b GeneProduct ensembl:ENSRNOG00000004649
Gng5 GeneProduct ensembl:ENSRNOG00000038205
Adm GeneProduct ensembl:ENSRNOG00000027030
Rgs16 GeneProduct ensembl:ENSRNOG00000027024
Itpr3 GeneProduct ensembl:ENSRNOG00000052795
Prkd1 GeneProduct ensembl:ENSRNOG00000004165
LOC100361457 GeneProduct ensembl:ENSRNOG00000036701
Gng8 GeneProduct ensembl:ENSRNOG00000016701
Rxfp2 GeneProduct ensembl:ENSRNOG00000000897
Gnb4 GeneProduct ensembl:ENSRNOG00000011070
Prkar1b GeneProduct ensembl:ENSRNOG00000028733
Rgs19 GeneProduct ensembl:ENSRNOG00000016547
ADP Metabolite cas:58-64-0
Actb GeneProduct ensembl:ENSRNOG00000034254
Corin GeneProduct ensembl:ENSRNOG00000002302
Gabpb1l GeneProduct ensembl:ENSRNOG00000053439
Prkcd GeneProduct ensembl:ENSRNOG00000016346
Sp1 GeneProduct ensembl:ENSRNOG00000014084
Gabpa GeneProduct ensembl:ENSRNOG00000053205
Adcy6 GeneProduct ensembl:ENSRNOG00000054757
Guca2a GeneProduct ensembl:ENSRNOG00000008849
Itpr1 GeneProduct ensembl:ENSRNOG00000007104
Camk2b GeneProduct ensembl:ENSRNOG00000052080
Crhr1 GeneProduct ensembl:ENSRNOG00000004900
Rln1 GeneProduct ensembl:ENSRNOG00000060867
Pde4d GeneProduct ensembl:ENSRNOG00000042536
Grk6 GeneProduct ensembl:ENSRNOG00000014615
Ets2 GeneProduct ensembl:ENSRNOG00000001647
Atf3 GeneProduct ensembl:ENSRNOG00000003745
Adcy4 GeneProduct ensembl:ENSRNOG00000020401
Plcd1 GeneProduct ensembl:ENSRNOG00000032238
Rgs4 GeneProduct ensembl:ENSRNOG00000002773
Rgs14 GeneProduct ensembl:ENSRNOG00000015616
Slc8a1 GeneProduct ensembl:ENSRNOG00000008479
Guca2b GeneProduct ensembl:ENSRNOG00000008979
Arrb1 GeneProduct ensembl:ENSRNOG00000030404
Gja1 GeneProduct ensembl:ENSRNOG00000000805
Arrb1 GeneProduct ensembl:ENSRNOG00000030404
Ywhag GeneProduct ensembl:ENSRNOG00000001436
Cacnb3 GeneProduct ensembl:ENSRNOG00000054274
Ackr3 GeneProduct ensembl:ENSRNOG00000019622
Igfbp1 GeneProduct ensembl:ENSRNOG00000058780
Pkig GeneProduct ensembl:ENSRNOG00000010235
Pde4b GeneProduct ensembl:ENSRNOG00000005905
Gngt1 GeneProduct ensembl:ENSRNOG00000010546
Pkia GeneProduct ensembl:ENSRNOG00000012095
Ywhaq GeneProduct ensembl:ENSRNOG00000051650
Cyclic GMP Metabolite hmdb:HMDB0001314
Creb3 GeneProduct ensembl:ENSRNOG00000016452
Actc1 GeneProduct ensembl:ENSRNOG00000008536
ADP Metabolite cas:58-64-0
Igfbp3 GeneProduct ensembl:ENSRNOG00000061910
Plcg1 GeneProduct ensembl:ENSRNOG00000051490
GNAS GeneProduct None
Maff GeneProduct ensembl:ENSRNOG00000012886
PRKACA GeneProduct None
CALM3 GeneProduct None
Atf2 GeneProduct ensembl:ENSRNOG00000001597
Gng4 GeneProduct ensembl:ENSRNOG00000047080
CALM2 GeneProduct None
Adcy9 GeneProduct ensembl:ENSRNOG00000049768
AABR07013776.1 GeneProduct ensembl:ENSRNOG00000048082
Acta1 GeneProduct ensembl:ENSRNOG00000017786
Gnb1 GeneProduct ensembl:ENSRNOG00000016638
Myl2 GeneProduct ensembl:ENSRNOG00000030848
Rgs3 GeneProduct ensembl:ENSRNOG00000024501
AABR07062512.1 GeneProduct ensembl:ENSRNOG00000053339
Plcb3 GeneProduct ensembl:ENSRNOG00000021150
ATP Metabolite cas:1927-31-7
Camk2a GeneProduct ensembl:ENSRNOG00000018712
Nfkb1 GeneProduct ensembl:ENSRNOG00000023258
Cyclic AMP Metabolite hmdb:HMDB0000058
Creb1 GeneProduct ensembl:ENSRNOG00000013412
Gucy1a3 GeneProduct ensembl:ENSRNOG00000012302

References

  1. Méhats C, Tanguy G, Dallot E, Cabrol D, Ferré F, Leroy MJ. Is up-regulation of phosphodiesterase 4 activity by PGE2 involved in the desensitization of beta-mimetics in late pregnancy human myometrium? J Clin Endocrinol Metab. 2001 Nov;86(11):5358–65. PubMed Europe PMC Scholia
  2. Aggelidou E, Hillhouse EW, Grammatopoulos DK. Up-regulation of nitric oxide synthase and modulation of the guanylate cyclase activity by corticotropin-releasing hormone but not urocortin II or urocortin III in cultured human pregnant myometrial cells. Proc Natl Acad Sci U S A. 2002 Mar 5;99(5):3300–5. PubMed Europe PMC Scholia
  3. Salomonis N, Cotte N, Zambon AC, Pollard KS, Vranizan K, Doniger SW, et al. Identifying genetic networks underlying myometrial transition to labor. Genome Biol. 2005;6(2):R12. PubMed Europe PMC Scholia