Ganglio sphingolipid metabolism (WP1423)

Sphingolipids are metabolites used to make cell-cell and cell-substratum interactions possible. This pathway describes how they are synthesized.
last edited

Authors

MaintBot, Khanspers, Michiel, AlexanderPico, Egonw, Mkutmon, Zari, DeSl, and Eweitz

Cited In

Organism

Homo sapiens

Communities

Annotations

Pathway Ontology: sphingolipid metabolic pathway sphingolipid biosynthetic pathway ganglioside metabolic pathway

Participants

Label Type Compact Identifier
Fuc-GM1 Metabolite chebi:90189
Fuc-GD1b Metabolite chebi:90265
O-Acetylated GD3 Metabolite pubchem.compound:73427362
GM1A Metabolite pubchem.compound:9963963
GT1aA Metabolite lipidmaps:LMSP0601BF00
GalNAc-GD1a Metabolite lipidmaps:LMSP0601BG00
GQ1bA Metabolite lipidmaps:LMSP0601BJ00
Gal-GD1b Metabolite lipidmaps:LMSP0601BH00
GalNAc-GM1 Metabolite lipidmaps:LMSP0601BC00
Gal-GlcNAc-GM1b Metabolite None
GM2A Metabolite kegg.glycan:G00130
GD1B Metabolite chebi:28175
GD1aA Metabolite lipidmaps:LMSP0601BE00
GalNAc-GM1b Metabolite pubchem.compound:73427345
GD1A Metabolite hmdb:HMDB0011777
O-Acetylated GT3 Metabolite kegg.glycan:G00170
B3GALT4 GeneProduct ensembl:ENSG00000235863
GT2 Metabolite pubchem.compound:53481325
B4GALNT1 GeneProduct ncbigene:2583
ST6GALNAC6 GeneProduct ensembl:ENSG00000160408
O-AcetylT GeneProduct ensembl:ENSG00000169359
ST6GALNAC6 GeneProduct ncbigene:30815
GD3 Metabolite hmdb:HMDB0004913
B4GALNT1 GeneProduct ncbigene:2583
O-AcetylT GeneProduct ensembl:ENSG00000169359
GQ1bA Metabolite hmdb:HMDB0004928
GA2 Metabolite hmdb:HMDB0004898
ST6GALNAC6 GeneProduct ncbigene:30815
FUT1 GeneProduct ncbigene:2523
ST8SIA5 GeneProduct ensembl:ENSG00000101638
GM1a Metabolite hmdb:HMDB0004855
GD1a Metabolite hmdb:HMDB0004853
GM3 Metabolite hmdb:HMDB0004844
A3GALT2 GeneProduct ncbigene:127550
ST3GAL2 GeneProduct ensembl:ENSG00000157350
ST3GAL5 GeneProduct ncbigene:8869
GM1b Metabolite pubchem.compound:53239726
B3GALT4 GeneProduct ensembl:ENSG00000235863
GQ1c Metabolite pubchem.compound:53481235
ST6GALNAC6 GeneProduct ncbigene:30815
ST8SIA5 GeneProduct ncbigene:29906
GT1b Metabolite hmdb:HMDB0004927
GP1c Metabolite lipidmaps:LMSP0601AX00
ST8SIA5 GeneProduct ensembl:ENSG00000101638
ST8SIA3 GeneProduct ncbigene:51046
B4GALNT1 GeneProduct ncbigene:2583
B4GALNT1 GeneProduct ncbigene:2583
GA1 Metabolite hmdb:HMDB0004910
ST3GAL1 GeneProduct ensembl:ENSG00000008513
ST8SIA5 GeneProduct ensembl:ENSG00000101638
B4GALNT1 GeneProduct ncbigene:2583
B3GAL GeneProduct ensembl:ENSG00000172318
ST3GAL1 GeneProduct ensembl:ENSG00000008513
GM2 Metabolite hmdb:HMDB0004938
GM3 Synthase GeneProduct ensembl:ENSG00000115525
ST3GAL1 GeneProduct ensembl:ENSG00000008513
ST8SIA1 GeneProduct ensembl:ENSG00000111728
GD1b Metabolite hmdb:HMDB0004926
B3GALT4 GeneProduct ncbigene:8705
ST8Sia1 GeneProduct ensembl:ENSG00000111728
FUT1 GeneProduct ncbigene:2523
ST8SIA1 GeneProduct ncbigene:6489
GT1a Metabolite pubchem.compound:45259173
B3GALT4 GeneProduct ensembl:ENSG00000235863
B3GALT4 GeneProduct ensembl:ENSG00000235863
LacCer Metabolite hmdb:HMDB0006750
ST3GAL2 GeneProduct ensembl:ENSG00000157350
GD2 Metabolite hmdb:HMDB0004925
ST8SIA5 GeneProduct ensembl:ENSG00000101638
GT1c Metabolite pubchem.compound:53481295
ST6GALNAC6 GeneProduct ncbigene:30815
ST3GAL1 GeneProduct ensembl:ENSG00000008513
B4GALNT1 GeneProduct ncbigene:2583
GD1c Metabolite lipidmaps:LMSP0601BN00
ST3GAL2 GeneProduct ensembl:ENSG00000157350
B4GALNT1 GeneProduct ncbigene:2583
GT3 Metabolite pubchem.compound:53481355
ST3GAL2 GeneProduct ensembl:ENSG00000157350
ST8SIA5 GeneProduct ensembl:ENSG00000101638

References

  1. Merrill AH Jr. De novo sphingolipid biosynthesis: a necessary, but dangerous, pathway. J Biol Chem. 2002 Jul 19;277(29):25843–6. PubMed Europe PMC Scholia