Statin pathway (WP145)

What are statins? See Wikipedia at: http://en.wikipedia.org/wiki/Statin More about this pathway and statins: https://www.pharmgkb.org/do/serve?objId=PA2031&objCls=Pathway
last edited

Authors

Nsalomonis, MaintBot, Khanspers, BruceConklin, Thomas, AlexanderPico, Ddigles, Egonw, L Dupuis, and Eweitz

Cited In

Organism

Rattus norvegicus

Communities

Annotations

Pathway Ontology: statin drug pathway

Cell Type Ontology: hepatocyte

Participants

Label Type Compact Identifier
Cholesterol Metabolite chebi:16113
Cholic Acid Metabolite chebi:16359
acetylCoA Metabolite chebi:15351
Phospholipid Metabolite chebi:16247
Cholesterol Ester Metabolite chebi:17002
Triglycerides Metabolite chebi:17855
Cholesterol Metabolite chebi:16113
Lipc GeneProduct ncbigene:24538
LDL Metabolite chebi:39026
HDL Metabolite chebi:39025
Lcat GeneProduct ncbigene:24530
Apoe GeneProduct ncbigene:25728
Cetp GeneProduct None
Lpl GeneProduct ncbigene:24539
Apoc1 GeneProduct ncbigene:25292
Apoc3 GeneProduct ncbigene:24207
Scarb1 GeneProduct ncbigene:25073
Dgat1 GeneProduct ncbigene:84497
Ldlr GeneProduct ncbigene:300438
Mttp GeneProduct ncbigene:310900
Free FA Metabolite chebi:35366
Apoa1 GeneProduct ncbigene:25081
Apoc2 GeneProduct ncbigene:25384
Hmgcr GeneProduct ncbigene:25675
Lrp1 GeneProduct ncbigene:299858
Statin Metabolite None
Apoa4 GeneProduct ncbigene:25080
Ptlp GeneProduct ncbigene:296371
Abca1 GeneProduct ncbigene:313210
Cyp7a1 GeneProduct ncbigene:25428
Soat1 GeneProduct ncbigene:81782

References

  1. Chen H, Ikeda U, Shimpo M, Shimada K. Direct effects of statins on cells primarily involved in atherosclerosis. Hypertens Res. 2000 Mar;23(2):187–92. PubMed Europe PMC Scholia