Kit receptor signaling pathway (WP147)

Kit is a receptor protein tyrosine kinase, which is a receptor for stem cell factor or kit ligand. Signaling through Kit is important for formation of red cells, lymphocytes, mast cells and platelets among others. Binding of Kit receptor to stem cell factor leads to an intracellular cascade of events that includes activation of PI 3-kinase, Src family kinases and PLC gamma. Activating mutations in the Kit receptor are associated with several human malignancies include leukemias, gastrointestinal stromal tumors and mastocytomas. Source: NetPath
last edited


A.Pandey, MaintBot, AlexanderPico, Ddigles, and Eweitz

Cited In


Rattus norvegicus



Pathway Ontology: Stem Cell Factor signaling pathway


Label Type Compact Identifier
Stat1 GeneProduct ncbigene:25124
Cish GeneProduct ncbigene:83681
Kitlg GeneProduct ncbigene:60427
Dok1 GeneProduct ncbigene:312477
Btk GeneProduct ncbigene:367901
Vav1 GeneProduct ncbigene:25156
Stat5a GeneProduct ncbigene:24918
Jak2 GeneProduct ncbigene:24514
Mpdz GeneProduct ncbigene:29365
Ptpn6 GeneProduct ncbigene:116689
Rps6ka1 GeneProduct ncbigene:81771
Prkcb GeneProduct ncbigene:25023
Grb7 GeneProduct ncbigene:84427
Socs5 GeneProduct ncbigene:500616
Sh2b2 GeneProduct ncbigene:114203
Map2k1 GeneProduct ncbigene:170851
Vav2 GeneProduct ncbigene:296603
Dok1 GeneProduct ncbigene:312477
Abl1 GeneProduct ncbigene:311860
Pik3r1 GeneProduct ncbigene:25513
Src GeneProduct ncbigene:83805
Raf1 GeneProduct ncbigene:24703
Kit GeneProduct ncbigene:64030
Ptpru GeneProduct ncbigene:116680
Inpp5d GeneProduct ncbigene:54259
Fgr GeneProduct ncbigene:79113
Yes1 GeneProduct ncbigene:24884
Stat5b GeneProduct ncbigene:25126
Akt1 GeneProduct ncbigene:24185
Kitlg GeneProduct ncbigene:60427
Socs4 GeneProduct ncbigene:305828
Grap GeneProduct ncbigene:363616
Matk GeneProduct ncbigene:60450
Hck GeneProduct ncbigene:25734
Pik3cg GeneProduct ncbigene:298947
Plcg1 GeneProduct ncbigene:25738
Crkl GeneProduct ncbigene:287942
Kit GeneProduct ncbigene:64030
Tnfrsf10b GeneProduct ncbigene:364420
Ep300 GeneProduct ncbigene:170915
Rasa1 GeneProduct ncbigene:25676
Socs1 GeneProduct ncbigene:252971
Ptpn11 GeneProduct ncbigene:25622
Fes GeneProduct ncbigene:361597
Csf2rb GeneProduct ncbigene:171081
Socs6 GeneProduct ncbigene:307200
Spred1 GeneProduct ncbigene:296072
Spred2 GeneProduct ncbigene:305539
Cltc GeneProduct ncbigene:54241
Mapk1 GeneProduct ncbigene:116590
Grb2 GeneProduct ncbigene:81504
Bad GeneProduct ncbigene:64639
Lyn GeneProduct ncbigene:81515
Cblb GeneProduct ncbigene:171136
Pik3r2 GeneProduct ncbigene:29741
Epor GeneProduct ncbigene:24336
Fyn GeneProduct ncbigene:25150
Grb10 GeneProduct ncbigene:498416
Prkca GeneProduct ncbigene:24680
Crk GeneProduct ncbigene:54245
Hras GeneProduct ncbigene:293621
Mitf GeneProduct ncbigene:25094
Plce1 GeneProduct ncbigene:114633
Sos1 GeneProduct ncbigene:313845
Shc1 GeneProduct ncbigene:85385
Stat3 GeneProduct ncbigene:25125
Tec GeneProduct ncbigene:84492
Stap1 GeneProduct ncbigene:305269
Sh3kbp1 GeneProduct ncbigene:84357
Cbl GeneProduct ncbigene:500985