Selenium micronutrient network (WP15)

The selenium-centred micronutrient biological network. The most relevant biochemical processes related to selenium in the context of metabolism, oxidation and inflammation are represented. Also, the compartmental separation (intracellular vs. plasma) is presented, identifying the selenium centred plasma metabolome. A selenoprotein database exists at: http://www.selenodb.org. Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP15 CPTAC Assay Portal]
last edited

Authors

Egoyenechea, AlexanderPico, Thomas, Ommen, MaintBot, Evelo, MartijnVanIersel, Jildau, Khanspers, Damariz, Andra, Egonw, Mkutmon, MirellaKalafati, DeSl, Eweitz, and Marvin M2

Cited In

Organism

Homo sapiens

Communities

Micronutrients

Annotations

Pathway Ontology: classic metabolic pathway selenoamino acid metabolic pathway

Participants

Label Type Compact Identifier
Lipoxin A4 Metabolite hmdb:HMDB0004385
PGD2 Metabolite hmdb:HMDB0001403
Arachidonic acid Metabolite hmdb:HMDB0001043
FGA Protein ensembl:ENSG00000171560
PGE1 Metabolite hmdb:HMDB0001442
Thromboxane B2 Metabolite hmdb:HMDB0003252
Lipoxin B4 Metabolite hmdb:HMDB0005082
Thromboxane A2 Metabolite hmdb:HMDB0001452
Linoleic acid Metabolite hmdb:HMDB0000673
a-Tocopherol Metabolite hmdb:HMDB0001893
Arachidonic acid Metabolite hmdb:HMDB0001043
Lipoxin A4 Metabolite hmdb:HMDB0004385
F2-Isoprostane Metabolite wikidata:Q33659470
DHA Metabolite hmdb:HMDB0002183
8-Isoprostaglandin F2a Metabolite hmdb:HMDB0005083
PGI2 Metabolite hmdb:HMDB0001335
PGE2 Metabolite hmdb:HMDB0001220
Thromboxane B2 Metabolite hmdb:HMDB0003252
RELA GeneProduct ncbigene:5970
MDA Metabolite hmdb:HMDB0006112
PGE2 Metabolite hmdb:HMDB0001220
a-Tocopherol Metabolite hmdb:HMDB0001893
PGI2 Metabolite hmdb:HMDB0001335
PGF2a Metabolite hmdb:HMDB0001139
DHA Metabolite hmdb:HMDB0002183
COX2 Protein ncbigene:5743
COX1 Protein ncbigene:5742
ALA Metabolite hmdb:HMDB0001388
PGF2a Metabolite hmdb:HMDB0001139
EPA Metabolite hmdb:HMDB0001999
PGD2 Metabolite hmdb:HMDB0001403
Linoleic acid Metabolite hmdb:HMDB0000673
PGE1 Metabolite hmdb:HMDB0001442
DGLA Metabolite hmdb:HMDB0002925
NFKB1 GeneProduct ncbigene:4790
F2-Isoprostane Metabolite wikidata:Q33659470
DPA Metabolite hmdb:HMDB0001976
Lipoxin B4 Metabolite hmdb:HMDB0005082
PGH3 Metabolite hmdb:HMDB0013040
PGG2 Metabolite hmdb:HMDB0003235
8-Isoprostaglandin F2a Metabolite hmdb:HMDB0005083
DPA Metabolite hmdb:HMDB0001976
EPA Metabolite hmdb:HMDB0001999
ALA Metabolite hmdb:HMDB0001388
NFKB2 GeneProduct ncbigene:4791
MDA Metabolite hmdb:HMDB0006112
PGH2 Metabolite hmdb:HMDB0001381
PGE3 Metabolite hmdb:HMDB0002664
Kynurenine Metabolite hmdb:HMDB0000684
MTR Protein ncbigene:4548
TRXR1 Protein ncbigene:7296
CBS Protein ncbigene:875
Iodine Metabolite wikidata:Q1103
Iodine Metabolite wikidata:Q1103
KMO Protein ncbigene:8564
R-Triiodothyronine (rT3) Metabolite chebi:28774
Triiodothyronine (T3) Metabolite chebi:18258
15-HETE Metabolite hmdb:HMDB0003876
Thyroxine (T4) Metabolite chebi:30660
5-HPETE Metabolite hmdb:HMDB0001193
5,6-Epoxytetraene Metabolite kegg.compound:C14815
R-Triiodothyronine (rT3) Metabolite chebi:28774
15-HETE Metabolite hmdb:HMDB0003876
Triiodothyronine (T3) Metabolite chebi:18258
5-HETE Metabolite hmdb:HMDB0011134
Thyroxine (T4) Metabolite chebi:30660
5-HETE Metabolite hmdb:HMDB0011134
NADP+ Metabolite hmdb:HMDB0000217
MPO Protein ncbigene:4353
Catalase Protein ncbigene:847
MPO Protein ncbigene:4353
Uric acid Metabolite hmdb:HMDB0000289
Cysteine Metabolite hmdb:HMDB0000574
Factor VII Protein ncbigene:2155
Thrombin Protein ncbigene:2147
tPA Protein ncbigene:5327
tPA Protein ncbigene:5327
PAI-1 Protein ncbigene:5054
PLG Protein ncbigene:5340
Thrombin Protein ncbigene:2147
Factor VII Protein ncbigene:2155
PLG Protein ncbigene:5340
PAI-1 Protein ncbigene:5054
GGT1 Protein ncbigene:2678
GPX 4 Protein ncbigene:2879
TRXR2 Protein ncbigene:10587
Xantine oxidase Protein ncbigene:7498
PRDX5 Protein ncbigene:25824
H2O2 Metabolite hmdb:HMDB0003125
ALOX5 Protein ncbigene:240
ALOX15B Protein ncbigene:247
Copper Metabolite hmdb:HMDB0000657
Uric acid Metabolite hmdb:HMDB0000289
Vitamin B12 Metabolite hmdb:HMDB0002174
5,10-Methylene-THF Metabolite hmdb:HMDB0001533
SelR Protein ncbigene:51734
Tryptophan Metabolite hmdb:HMDB0000929
5-methyl-THF Metabolite hmdb:HMDB0001396
SOD3 Protein ncbigene:6649
PRDX1 Protein ncbigene:5052
RFK Protein ncbigene:55312
H2O Metabolite hmdb:HMDB0002111
GPX 3 Protein ncbigene:2878
Niacinamide Metabolite hmdb:HMDB0001406
CTH Protein ncbigene:1491
PNPO Protein ncbigene:55163
Heme Metabolite HMDB
NADPH Metabolite HMDB
Lipoic acid Metabolite HMDB
Manganese Metabolite HMDB
FAD Metabolite HMDB
Methionine sulfoxide Metabolite HMDB
Dehydroascorbic acid Metabolite ChEBI
Leukotriene A4 Metabolite HMDB
NADPH Metabolite HMDB
FAD Metabolite HMDB
THF Metabolite HMDB
Hydroxykynurenine Metabolite HMDB
Folic acid Metabolite HMDB
NADP+ Metabolite HMDB
NADPH Metabolite HMDB
Selenium Metabolite HMDB
Selenium Metabolite HMDB
SelK Protein Entrez Gene
Sep15 Protein Entrez Gene
GPX 6 Protein Entrez Gene
GSH Metabolite HMDB
Nicotinamidase Protein Enzyme Nomenclature
Calcium Metabolite HMDB
Methionine Metabolite HMDB
Manganese Metabolite HMDB
NADPH Metabolite HMDB
Folic acid Metabolite HMDB
FMN Metabolite HMDB
Selenocysteine Metabolite HMDB
Selenide Metabolite ChEBI
Selenophosphate Metabolite ChEBI
Cysteine Metabolite HMDB
Leukotriene C4 Metabolite HMDB
Leukotriene C4 Metabolite HMDB
GPX 3 Protein Entrez Gene
Dehydroascorbic acid Metabolite ChEBI
GPX 2 Protein Entrez Gene
SelP Protein Entrez Gene
Trx-S2 Protein Entrez Gene
Ascorbic acid Metabolite ChEBI
Lipoic acid Metabolite HMDB
PRDX4 Protein Entrez Gene
GPX 1 Protein Entrez Gene
NADP+ Metabolite HMDB
Homocysteine Metabolite HMDB
ROS Metabolite ChEBI
RNS Metabolite ChEBI
NADPH Metabolite HMDB
Vitamin B12 Metabolite HMDB
MTHFR Protein Entrez Gene
Homocysteine Metabolite HMDB
SelH Protein Entrez Gene
SPS2 Protein Entrez Gene
SelO Protein Entrez Gene
SelN Protein Entrez Gene
DIO2 Protein Entrez Gene
SelT Protein Entrez Gene
SelM Protein Entrez Gene
SelP Protein Entrez Gene
DIO3 Protein Entrez Gene
DIO1 Protein Entrez Gene
SelV Protein Entrez Gene
SelI Protein Entrez Gene
SelS Protein Entrez Gene
SOD1 Protein Entrez Gene
Pyridoxal 5-phosphate None
Metabolite HMDB0001491 None
Serine Metabolite hmdb:HMDB0000187
Iron Metabolite wikidata:Q26840996
Hypoxanthine Metabolite hmdb:HMDB0000157
PRDX3 Protein ncbigene:10935
GSR Protein ncbigene:2936
APOA1 Protein ncbigene:335
APOB Protein ncbigene:338
LDLR Protein ncbigene:3949
VLDL Metabolite chebi:39027
LDL Metabolite chebi:39026
SAA4 Protein ncbigene:6291
SRB1 Protein ncbigene:949
ABCA1 Protein ncbigene:19
Cholesterol Metabolite hmdb:HMDB0000067
APOA1-NO2Tyr Protein ncbigene:335
ACT Protein ncbigene:12
HDL Metabolite chebi:39025
VLDL-TAG Metabolite chebi:47776
FMN Metabolite hmdb:HMDB0001520
SAA2 Protein ncbigene:6289
HDL-C Metabolite chebi:47775
TAG Metabolite chebi:17855
ACT Protein ncbigene:12
APOA1 Protein ncbigene:335
HDL Metabolite chebi:39025
HDL-C Metabolite chebi:47775
SAA1 Protein ncbigene:6288
SAA3 Protein ncbigene:6290
APOB Protein ncbigene:338
VLDL Metabolite chebi:39027
oxLDL Metabolite chebi:60151
HDL/APOA1 Metabolite chebi:39025
HDL/SAA Metabolite chebi:39025
Cholesterol Metabolite hmdb:HMDB0000067
oxLDL Metabolite chebi:60151
TAG Metabolite chebi:17855
LDL Metabolite chebi:39026
VLDL-TAG Metabolite chebi:47776
VLDL/APOB Metabolite chebi:39027
O2 Metabolite hmdb:HMDB0001377
Pyridoxal 5-phosphate Metabolite HMDB
8-OHdG Metabolite HMDB
8-OHdG Metabolite HMDB
FAD Metabolite HMDB
PRDX2 Protein Entrez Gene
ADP Metabolite HMDB
Leukotriene D4 Metabolite HMDB
Leukotriene D4 Metabolite HMDB
Copper Metabolite HMDB
Chlorine Metabolite HMDB
Chlorine Metabolite HMDB
Cystathionine Metabolite HMDB
FAD Metabolite HMDB
SOD2 Protein Entrez Gene
Dihydrolipoate Metabolite HMDB
Serine Metabolite HMDB
NADP+ Metabolite HMDB
ATP Metabolite HMDB
Zinc Metabolite HMDB
NADP+ Metabolite HMDB
GSSG Metabolite HMDB
NADPH Metabolite HMDB
Zinc Metabolite HMDB
Niacin Metabolite HMDB
Leukotriene B4 Metabolite HMDB
Leukotriene B4 Metabolite HMDB
Quinolinic Acid Metabolite HMDB
PMP Metabolite HMDB
NO Metabolite hmdb:HMDB0003378
O3 Metabolite chebi:25812
NO Metabolite hmdb:HMDB0003378
HNO2 Metabolite chebi:25567
NO2 Metabolite chebi:33101
HOCl Metabolite hmdb:HMDB0001050
NADP+ Metabolite hmdb:HMDB0000217
GSH Metabolite hmdb:HMDB0000125
sICAM-1 Protein ncbigene:3383
D-dimer Protein None
IL10 Protein ncbigene:3458
TNFa Protein ncbigene:7124
HbA1c Protein None
IFNg Protein ncbigene:3458
ALB Protein ncbigene:213
INS Protein ncbigene:3630
Fibrin Metabolite wikidata:Q27205
IL1B Protein ncbigene:3553
INSR Protein ncbigene:3643
HBB Protein ncbigene:3043
TNFa Protein ncbigene:7124
CRP Protein ncbigene:1401
Fibrin Protein wikidata:Q27205
IL1B Protein ncbigene:3553
IFNg Protein ncbigene:3458
sICAM-1 Protein ncbigene:3383
CCL2 Protein ncbigene:6347
INS Protein ncbigene:3630
IL10 Protein ncbigene:3458
ALB Protein ncbigene:213
FLAP Protein ncbigene:241
IL6 Protein ncbigene:3569
CCL2 Protein ncbigene:6347
IL6 Protein ncbigene:3569
Fibrinogen Protein None
Fibrinogen Protein None
D-dimer Protein None
HBA1 Protein ncbigene:3039
HbA1c Protein None
SelW Protein ncbigene:6415
Riboflavin Metabolite hmdb:HMDB0000244
SOD3 Protein ncbigene:6649
TRXR1 Protein ncbigene:7296
Ascorbate Metabolite chebi:38290
O2-“ Metabolite hmdb:HMDB0002168
Xanthine Metabolite hmdb:HMDB0000292
Calcium Metabolite hmdb:HMDB0000464
Kynureninase Protein ncbigene:8942
Methionine Metabolite hmdb:HMDB0000696
ADP Metabolite hmdb:HMDB0001341
Trx-(SH)2 Protein ncbigene:7295
Nitrotyrosine Metabolite hmdb:HMDB0001904
ONOO-/ONOOH Metabolite hmdb:HMDB0002179
Nitrotyrosine Metabolite hmdb:HMDB0001904
ATP Metabolite hmdb:HMDB0000538
Leukotriene E4 Metabolite hmdb:HMDB0002200
Leukotriene E4 Metabolite hmdb:HMDB0002200
Leukotriene F4 Metabolite hmdb:HMDB0006465
Glucose Metabolite hmdb:HMDB0000122
Fructosamine Metabolite hmdb:HMDB0002030
Fructosamine Metabolite hmdb:HMDB0002030
Iron Metabolite wikidata:Q26840996
Hypoxanthine Metabolite hmdb:HMDB0000157
TRXR3 Protein ncbigene:114112
FLAD1 Protein ncbigene:80308
Ascorbic acid Metabolite chebi:29073
FGB Protein ensembl:ENSG00000171564
FGG Protein ensembl:ENSG00000171557

References

  1. Needleman P, Raz A, Minkes MS, Ferrendelli JA, Sprecher H. Triene prostaglandins: prostacyclin and thromboxane biosynthesis and unique biological properties. Proc Natl Acad Sci U S A. 1979 Feb;76(2):944–8. PubMed Europe PMC Scholia
  2. Kilpatrick L, Johnson JL, Nickbarg EB, Wang ZM, Clifford TF, Banach M, et al. Inhibition of human neutrophil superoxide generation by alpha 1-antichymotrypsin. J Immunol. 1991 Apr 1;146(7):2388–93. PubMed Europe PMC Scholia
  3. Huwyler J, Bürgin M, Zeugin T, Gut J. Transformation of 5-hydroperoxyeicosatetraenoic acid into dihydroxy- and cysteinyl-leukotrienes by rat hepatocytes: effects of glutathione. Mol Pharmacol. 1991 Mar;39(3):314–23. PubMed Europe PMC Scholia
  4. Isseroff RR, Ziboh VA, Chapkin RS, Martinez DT. Conversion of linoleic acid into arachidonic acid by cultured murine and human keratinocytes. J Lipid Res. 1987 Nov;28(11):1342–9. PubMed Europe PMC Scholia
  5. Shigenaga MK, Gimeno CJ, Ames BN. Urinary 8-hydroxy-2’-deoxyguanosine as a biological marker of in vivo oxidative DNA damage. Proc Natl Acad Sci U S A. 1989 Dec;86(24):9697–701. PubMed Europe PMC Scholia
  6. McCay PB. Vitamin E: interactions with free radicals and ascorbate. Annu Rev Nutr. 1985;5:323–40. PubMed Europe PMC Scholia
  7. Herbert V. Vitamin B-12: plant sources, requirements, and assay. Am J Clin Nutr. 1988 Sep;48(3 Suppl):852–8. PubMed Europe PMC Scholia
  8. Reilly IA, FitzGerald GA. Inhibition of thromboxane formation in vivo and ex vivo: implications for therapy with platelet inhibitory drugs. Blood. 1987 Jan;69(1):180–6. PubMed Europe PMC Scholia
  9. Clifton PM, Mackinnon AM, Barter PJ. Effects of serum amyloid A protein (SAA) on composition, size, and density of high density lipoproteins in subjects with myocardial infarction. J Lipid Res. 1985 Dec;26(12):1389–98. PubMed Europe PMC Scholia
  10. Yamashita S, Hosaka K, Numa S. Acyl-donor specificities of partially purified 1-acylglycerophosphate acyltransferase, 2-acylglycerophosphate acyltransferase and 1-acylglycerophosphorylcholine acyltransferase from rat-liver microsomes. Eur J Biochem. 1973 Sep 21;38(1):25–31. PubMed Europe PMC Scholia
  11. Anderson ME, Allison RD, Meister A. Interconversion of leukotrienes catalyzed by purified gamma-glutamyl transpeptidase: concomitant formation of leukotriene D4 and gamma-glutamyl amino acids. Proc Natl Acad Sci U S A. 1982 Feb;79(4):1088–91. PubMed Europe PMC Scholia
  12. Denis D, Charleson S, Rackham A, Jones TR, Ford-Hutchinson AW, Lord A, et al. Synthesis and biological activities of leukotriene F4 and leukotriene F4 sulfone. Prostaglandins. 1982 Dec;24(6):801–14. PubMed Europe PMC Scholia
  13. Hammarström S. Leukotrienes. Annu Rev Biochem. 1983;52:355–77. PubMed Europe PMC Scholia
  14. Bender DA. Biochemistry of tryptophan in health and disease. Mol Aspects Med. 1983;6(2):101–97. PubMed Europe PMC Scholia
  15. Packer L, Witt EH, Tritschler HJ. alpha-Lipoic acid as a biological antioxidant. Free Radic Biol Med. 1995 Aug;19(2):227–50. PubMed Europe PMC Scholia
  16. Becker BF. Towards the physiological function of uric acid. Free Radic Biol Med. 1993 Jun;14(6):615–31. PubMed Europe PMC Scholia
  17. Mancini JA, Abramovitz M, Cox ME, Wong E, Charleson S, Perrier H, et al. 5-lipoxygenase-activating protein is an arachidonate binding protein. FEBS Lett. 1993 Mar 8;318(3):277–81. PubMed Europe PMC Scholia
  18. Schnurr K, Belkner J, Ursini F, Schewe T, Kühn H. The selenoenzyme phospholipid hydroperoxide glutathione peroxidase controls the activity of the 15-lipoxygenase with complex substrates and preserves the specificity of the oxygenation products. J Biol Chem. 1996 Mar 1;271(9):4653–8. PubMed Europe PMC Scholia
  19. Arnér ES, Nordberg J, Holmgren A. Efficient reduction of lipoamide and lipoic acid by mammalian thioredoxin reductase. Biochem Biophys Res Commun. 1996 Aug 5;225(1):268–74. PubMed Europe PMC Scholia
  20. Guimarães MJ, Peterson D, Vicari A, Cocks BG, Copeland NG, Gilbert DJ, et al. Identification of a novel selD homolog from eukaryotes, bacteria, and archaea: is there an autoregulatory mechanism in selenocysteine metabolism? Proc Natl Acad Sci U S A. 1996 Dec 24;93(26):15086–91. PubMed Europe PMC Scholia
  21. Hussein O, Rosenblat M, Refael G, Aviram M. Dietary selenium increases cellular glutathione peroxidase activity and reduces the enhanced susceptibility to lipid peroxidation of plasma and low-density lipoprotein in kidney transplant recipients. Transplantation. 1997 Mar 15;63(5):679–85. PubMed Europe PMC Scholia
  22. Serhan CN. Lipoxins and novel aspirin-triggered 15-epi-lipoxins (ATL): a jungle of cell-cell interactions or a therapeutic opportunity? Prostaglandins. 1997 Feb;53(2):107–37. PubMed Europe PMC Scholia
  23. May JM, Mendiratta S, Hill KE, Burk RF. Reduction of dehydroascorbate to ascorbate by the selenoenzyme thioredoxin reductase. J Biol Chem. 1997 Sep 5;272(36):22607–10. PubMed Europe PMC Scholia
  24. Paz K, Hemi R, LeRoith D, Karasik A, Elhanany E, Kanety H, et al. A molecular basis for insulin resistance. Elevated serine/threonine phosphorylation of IRS-1 and IRS-2 inhibits their binding to the juxtamembrane region of the insulin receptor and impairs their ability to undergo insulin-induced tyrosine phosphorylation. J Biol Chem. 1997 Nov 21;272(47):29911–8. PubMed Europe PMC Scholia
  25. Imai H, Narashima K, Arai M, Sakamoto H, Chiba N, Nakagawa Y. Suppression of leukotriene formation in RBL-2H3 cells that overexpressed phospholipid hydroperoxide glutathione peroxidase. J Biol Chem. 1998 Jan 23;273(4):1990–7. PubMed Europe PMC Scholia
  26. Gladyshev VN, Jeang KT, Wootton JC, Hatfield DL. A new human selenium-containing protein. Purification, characterization, and cDNA sequence. J Biol Chem. 1998 Apr 10;273(15):8910–5. PubMed Europe PMC Scholia
  27. Engels F, Nijkamp FP. Pharmacological inhibition of leukotriene actions. Pharm World Sci. 1998 Apr;20(2):60–5. PubMed Europe PMC Scholia
  28. Finkelstein JD. The metabolism of homocysteine: pathways and regulation. Eur J Pediatr. 1998 Apr;157 Suppl 2:S40-4. PubMed Europe PMC Scholia
  29. Mamalakis G, Kafatos A, Tornaritis M, Alevizos B. Anxiety and adipose essential fatty acid precursors for prostaglandin E1 and E2. J Am Coll Nutr. 1998 Jun;17(3):239–43. PubMed Europe PMC Scholia
  30. Wu D, Mura C, Beharka AA, Han SN, Paulson KE, Hwang D, et al. Age-associated increase in PGE2 synthesis and COX activity in murine macrophages is reversed by vitamin E. Am J Physiol. 1998 Sep;275(3):C661-8. PubMed Europe PMC Scholia
  31. Dubois RN, Abramson SB, Crofford L, Gupta RA, Simon LS, Van De Putte LB, et al. Cyclooxygenase in biology and disease. FASEB J. 1998 Sep;12(12):1063–73. PubMed Europe PMC Scholia
  32. Janciauskiene S, Wright HT. Inflammation, antichymotrypsin, and lipid metabolism: autogenic etiology of Alzheimer’s disease. Bioessays. 1998 Dec;20(12):1039–46. PubMed Europe PMC Scholia
  33. Marnett LJ. Lipid peroxidation-DNA damage by malondialdehyde. Mutat Res. 1999 Mar 8;424(1–2):83–95. PubMed Europe PMC Scholia
  34. Salem N Jr, Pawlosky R, Wegher B, Hibbeln J. In vivo conversion of linoleic acid to arachidonic acid in human adults. Prostaglandins Leukot Essent Fatty Acids. 1999;60(5–6):407–10. PubMed Europe PMC Scholia
  35. Brigelius-Flohé R. Tissue-specific functions of individual glutathione peroxidases. Free Radic Biol Med. 1999 Nov;27(9–10):951–65. PubMed Europe PMC Scholia
  36. Al-Obaidi MK, Philippou H, Stubbs PJ, Adami A, Amersey R, Noble MM, et al. Relationships between homocysteine, factor VIIa, and thrombin generation in acute coronary syndromes. Circulation. 2000 Feb 1;101(4):372–7. PubMed Europe PMC Scholia
  37. Hesse-Bähr K, Dreher I, Köhrle J. The influence of the cytokines Il-1beta and INFgamma on the expression of selenoproteins in the human hepatocarcinoma cell line HepG2. Biofactors. 2000;11(1–2):83–5. PubMed Europe PMC Scholia
  38. Evans P, Halliwell B. Free radicals and hearing. Cause, consequence, and criteria. Ann N Y Acad Sci. 1999 Nov 28;884:19–40. PubMed Europe PMC Scholia
  39. Abu-Soud HM, Hazen SL. Nitric oxide is a physiological substrate for mammalian peroxidases. J Biol Chem. 2000 Dec 1;275(48):37524–32. PubMed Europe PMC Scholia
  40. Abate A, Yang G, Dennery PA, Oberle S, Schröder H. Synergistic inhibition of cyclooxygenase-2 expression by vitamin E and aspirin. Free Radic Biol Med. 2000 Dec;29(11):1135–42. PubMed Europe PMC Scholia
  41. Whanger PD. Selenoprotein W: a review. Cell Mol Life Sci. 2000 Dec;57(13–14):1846–52. PubMed Europe PMC Scholia
  42. Esmon CT. Does inflammation contribute to thrombotic events? Haemostasis. 2000;30 Suppl 2:34–40. PubMed Europe PMC Scholia
  43. Powis G, Montfort WR. Properties and biological activities of thioredoxins. Annu Rev Pharmacol Toxicol. 2001;41:261–95. PubMed Europe PMC Scholia
  44. Schnedl WJ, Liebminger A, Roller RE, Lipp RW, Krejs GJ. Hemoglobin variants and determination of glycated hemoglobin (HbA1c). Diabetes Metab Res Rev. 2001;17(2):94–8. PubMed Europe PMC Scholia
  45. Maccarrone M, Meloni C, Manca-di-Villahermosa S, Cococcetta N, Casciani CU, Finazzi-Agrò A, et al. Vitamin E suppresses 5-lipoxygenase-mediated oxidative stress in peripheral blood mononuclear cells of hemodialysis patients regardless of administration route. Am J Kidney Dis. 2001 May;37(5):964–9. PubMed Europe PMC Scholia
  46. Smith WL, Langenbach R. Why there are two cyclooxygenase isozymes. J Clin Invest. 2001 Jun;107(12):1491–5. PubMed Europe PMC Scholia
  47. Lijnen HR. Elements of the fibrinolytic system. Ann N Y Acad Sci. 2001;936:226–36. PubMed Europe PMC Scholia
  48. Molnár I, Balázs C, Szegedi G, Sipka S. Inhibition of type 2,5’-deiodinase by tumor necrosis factor alpha, interleukin-6 and interferon gamma in human thyroid tissue. Immunol Lett. 2002 Jan 1;80(1):3–7. PubMed Europe PMC Scholia
  49. Edmondson DE, Newton-Vinson P. The covalent FAD of monoamine oxidase: structural and functional role and mechanism of the flavinylation reaction. Antioxid Redox Signal. 2001 Oct;3(5):789–806. PubMed Europe PMC Scholia
  50. Korotkov KV, Novoselov SV, Hatfield DL, Gladyshev VN. Mammalian selenoprotein in which selenocysteine (Sec) incorporation is supported by a new form of Sec insertion sequence element. Mol Cell Biol. 2002 Mar;22(5):1402–11. PubMed Europe PMC Scholia
  51. Saavedra WF, Paolocci N, St John ME, Skaf MW, Stewart GC, Xie J-S, et al. Imbalance between xanthine oxidase and nitric oxide synthase signaling pathways underlies mechanoenergetic uncoupling in the failing heart. Circ Res. 2002 Feb 22;90(3):297–304. PubMed Europe PMC Scholia
  52. Bates CJ, Thane CW, Prentice A, Delves HT. Selenium status and its correlates in a British national diet and nutrition survey: people aged 65 years and over. J Trace Elem Med Biol. 2002;16(1):1–8. PubMed Europe PMC Scholia
  53. Levin G, Duffin KL, Obukowicz MG, Hummert SL, Fujiwara H, Needleman P, et al. Differential metabolism of dihomo-gamma-linolenic acid and arachidonic acid by cyclo-oxygenase-1 and cyclo-oxygenase-2: implications for cellular synthesis of prostaglandin E1 and prostaglandin E2. Biochem J. 2002 Jul 15;365(Pt 2):489–96. PubMed Europe PMC Scholia
  54. Jeong D won, Kim TS, Chung YW, Lee BJ, Kim IY. Selenoprotein W is a glutathione-dependent antioxidant in vivo. FEBS Lett. 2002 Apr 24;517(1–3):225–8. PubMed Europe PMC Scholia
  55. Hink HU, Santanam N, Dikalov S, McCann L, Nguyen AD, Parthasarathy S, et al. Peroxidase properties of extracellular superoxide dismutase: role of uric acid in modulating in vivo activity. Arterioscler Thromb Vasc Biol. 2002 Sep 1;22(9):1402–8. PubMed Europe PMC Scholia
  56. Murakami M, Nakatani Y, Tanioka T, Kudo I. Prostaglandin E synthase. Prostaglandins Other Lipid Mediat. 2002 Aug;68–69:383–99. PubMed Europe PMC Scholia
  57. Watanabe K. Prostaglandin F synthase. Prostaglandins Other Lipid Mediat. 2002 Aug;68–69:401–7. PubMed Europe PMC Scholia
  58. Wang L-H, Kulmacz RJ. Thromboxane synthase: structure and function of protein and gene. Prostaglandins Other Lipid Mediat. 2002 Aug;68–69:409–22. PubMed Europe PMC Scholia
  59. Inoue T, Irikura D, Okazaki N, Kinugasa S, Matsumura H, Uodome N, et al. Mechanism of metal activation of human hematopoietic prostaglandin D synthase. Nat Struct Biol. 2003 Apr;10(4):291–6. PubMed Europe PMC Scholia
  60. Burk RF, Hill KE, Motley AK. Selenoprotein metabolism and function: evidence for more than one function for selenoprotein P. J Nutr. 2003 May;133(5 Suppl 1):1517S-20S. PubMed Europe PMC Scholia
  61. Kryukov GV, Castellano S, Novoselov SV, Lobanov AV, Zehtab O, Guigó R, et al. Characterization of mammalian selenoproteomes. Science. 2003 May 30;300(5624):1439–43. PubMed Europe PMC Scholia
  62. Peters-Golden M, Brock TG. 5-lipoxygenase and FLAP. Prostaglandins Leukot Essent Fatty Acids. 2003;69(2–3):99–109. PubMed Europe PMC Scholia
  63. Karthikeyan S, Zhou Q, Osterman AL, Zhang H. Ligand binding-induced conformational changes in riboflavin kinase: structural basis for the ordered mechanism. Biochemistry. 2003 Nov 4;42(43):12532–8. PubMed Europe PMC Scholia
  64. Sneddon AA, Wu H-C, Farquharson A, Grant I, Arthur JR, Rotondo D, et al. Regulation of selenoprotein GPx4 expression and activity in human endothelial cells by fatty acids, cytokines and antioxidants. Atherosclerosis. 2003 Nov;171(1):57–65. PubMed Europe PMC Scholia
  65. Witkowska AM, Kuryliszyn-Moskal A, Borawska MH, Hukałowicz K, Markiewicz R. A study on soluble intercellular adhesion molecule-1 and selenium in patients with rheumatoid arthritis complicated by vasculitis. Clin Rheumatol. 2003 Dec;22(6):414–9. PubMed Europe PMC Scholia
  66. Magni G, Amici A, Emanuelli M, Orsomando G, Raffaelli N, Ruggieri S. Enzymology of NAD+ homeostasis in man. Cell Mol Life Sci. 2004 Jan;61(1):19–34. PubMed Europe PMC Scholia
  67. Guzik TJ, Korbut R, Adamek-Guzik T. Nitric oxide and superoxide in inflammation and immune regulation. J Physiol Pharmacol. 2003 Dec;54(4):469–87. PubMed Europe PMC Scholia
  68. Gao Y, Feng HC, Walder K, Bolton K, Sunderland T, Bishara N, et al. Regulation of the selenoprotein SelS by glucose deprivation and endoplasmic reticulum stress - SelS is a novel glucose-regulated protein. FEBS Lett. 2004 Apr 9;563(1–3):185–90. PubMed Europe PMC Scholia
  69. Ye Y, Shibata Y, Yun C, Ron D, Rapoport TA. A membrane protein complex mediates retro-translocation from the ER lumen into the cytosol. Nature. 2004 Jun 24;429(6994):841–7. PubMed Europe PMC Scholia
  70. Zheng L, Nukuna B, Brennan M-L, Sun M, Goormastic M, Settle M, et al. Apolipoprotein A-I is a selective target for myeloperoxidase-catalyzed oxidation and functional impairment in subjects with cardiovascular disease. J Clin Invest. 2004 Aug;114(4):529–41. PubMed Europe PMC Scholia
  71. Simmons DL, Botting RM, Hla T. Cyclooxygenase isozymes: the biology of prostaglandin synthesis and inhibition. Pharmacol Rev. 2004 Sep;56(3):387–437. PubMed Europe PMC Scholia
  72. Schöneich C. Methionine oxidation by reactive oxygen species: reaction mechanisms and relevance to Alzheimer’s disease. Biochim Biophys Acta. 2005 Jan 17;1703(2):111–9. PubMed Europe PMC Scholia
  73. Hansel A, Heinemann SH, Hoshi T. Heterogeneity and function of mammalian MSRs: enzymes for repair, protection and regulation. Biochim Biophys Acta. 2005 Jan 17;1703(2):239–47. PubMed Europe PMC Scholia
  74. Klebanoff SJ. Myeloperoxidase: friend and foe. J Leukoc Biol. 2005 May;77(5):598–625. PubMed Europe PMC Scholia
  75. Doo Y-C, Han S-J, Park W-J, Kim S-M, Choi S-H, Cho G-Y, et al. Associations between C-reactive protein and circulating cell adhesion molecules in patients with unstable angina undergoing coronary intervention and their clinical implication. Clin Cardiol. 2005 Jan;28(1):47–51. PubMed Europe PMC Scholia
  76. Smith WL. Cyclooxygenases, peroxide tone and the allure of fish oil. Curr Opin Cell Biol. 2005 Apr;17(2):174–82. PubMed Europe PMC Scholia
  77. Weisel JW. Fibrinogen and fibrin. Adv Protein Chem. 2005;70:247–99. PubMed Europe PMC Scholia
  78. Kimura T, Nakanishi K, Nakagawa T, Shibukawa A, Matsuzaki K. Simultaneous determination of unbound thyroid hormones in human plasma using high performance frontal analysis with electrochemical detection. J Pharm Biomed Anal. 2005 Jun 15;38(2):204–9. PubMed Europe PMC Scholia
  79. Lewis GF, Rader DJ. New insights into the regulation of HDL metabolism and reverse cholesterol transport. Circ Res. 2005 Jun 24;96(12):1221–32. PubMed Europe PMC Scholia
  80. van der Westhuyzen DR, Cai L, de Beer MC, de Beer FC. Serum amyloid A promotes cholesterol efflux mediated by scavenger receptor B-I. J Biol Chem. 2005 Oct 28;280(43):35890–5. PubMed Europe PMC Scholia
  81. Köhrle J, Jakob F, Contempré B, Dumont JE. Selenium, the thyroid, and the endocrine system. Endocr Rev. 2005 Dec;26(7):944–84. PubMed Europe PMC Scholia
  82. Kovacs E. The serum levels of soluble intercellular adhesion molecule-1 (sICAM-1) and soluble gp130 (sgp130) in different tumour stages. Correlation between the two parameters in progression of malignancy. Biomed Pharmacother. 2005 Oct;59(9):498–500. PubMed Europe PMC Scholia
  83. Ferguson AD, Labunskyy VM, Fomenko DE, Araç D, Chelliah Y, Amezcua CA, et al. NMR structures of the selenoproteins Sep15 and SelM reveal redox activity of a new thioredoxin-like family. J Biol Chem. 2006 Feb 10;281(6):3536–43. PubMed Europe PMC Scholia
  84. Heirman I, Ginneberge D, Brigelius-Flohé R, Hendrickx N, Agostinis P, Brouckaert P, et al. Blocking tumor cell eicosanoid synthesis by GP x 4 impedes tumor growth and malignancy. Free Radic Biol Med. 2006 Jan 15;40(2):285–94. PubMed Europe PMC Scholia
  85. Galijasevic S, Saed GM, Hazen SL, Abu-Soud HM. Myeloperoxidase metabolizes thiocyanate in a reaction driven by nitric oxide. Biochemistry. 2006 Jan 31;45(4):1255–62. PubMed Europe PMC Scholia
  86. Gao Y, Hannan NRF, Wanyonyi S, Konstantopolous N, Pagnon J, Feng HC, et al. Activation of the selenoprotein SEPS1 gene expression by pro-inflammatory cytokines in HepG2 cells. Cytokine. 2006 Mar 7;33(5):246–51. PubMed Europe PMC Scholia
  87. Malle E, Marsche G, Arnhold J, Davies MJ. Modification of low-density lipoprotein by myeloperoxidase-derived oxidants and reagent hypochlorous acid. Biochim Biophys Acta. 2006 Apr;1761(4):392–415. PubMed Europe PMC Scholia
  88. Agaugué S, Perrin-Cocon L, Coutant F, André P, Lotteau V. 1-Methyl-tryptophan can interfere with TLR signaling in dendritic cells independently of IDO activity. J Immunol. 2006 Aug 15;177(4):2061–71. PubMed Europe PMC Scholia
  89. Lu C, Qiu F, Zhou H, Peng Y, Hao W, Xu J, et al. Identification and characterization of selenoprotein K: an antioxidant in cardiomyocytes. FEBS Lett. 2006 Oct 2;580(22):5189–97. PubMed Europe PMC Scholia
  90. Bianco AC, Kim BW. Deiodinases: implications of the local control of thyroid hormone action. J Clin Invest. 2006 Oct;116(10):2571–9. PubMed Europe PMC Scholia
  91. Videla LA, Rodrigo R, Araya J, Poniachik J. Insulin resistance and oxidative stress interdependency in non-alcoholic fatty liver disease. Trends Mol Med. 2006 Dec;12(12):555–8. PubMed Europe PMC Scholia
  92. Brigelius-Flohé R. Glutathione peroxidases and redox-regulated transcription factors. Biol Chem. 2006;387(10–11):1329–35. PubMed Europe PMC Scholia
  93. Scheurig AC, Thorand B, Fischer B, Heier M, Koenig W. Association between the intake of vitamins and trace elements from supplements and C-reactive protein: results of the MONICA/KORA Augsburg study. Eur J Clin Nutr. 2008 Jan;62(1):127–37. PubMed Europe PMC Scholia
  94. Labunskyy VM, Hatfield DL, Gladyshev VN. The Sep15 protein family: roles in disulfide bond formation and quality control in the endoplasmic reticulum. IUBMB Life. 2007 Jan;59(1):1–5. PubMed Europe PMC Scholia
  95. Ben Jilani KE, Panee J, He Q, Berry MJ, Li P-A. Overexpression of selenoprotein H reduces Ht22 neuronal cell death after UVB irradiation by preventing superoxide formation. Int J Biol Sci. 2007 Feb 11;3(4):198–204. PubMed Europe PMC Scholia
  96. Bleys J, Navas-Acien A, Guallar E. Serum selenium and diabetes in U.S. adults. Diabetes Care. 2007 Apr;30(4):829–34. PubMed Europe PMC Scholia
  97. Traber MG. Vitamin E regulatory mechanisms. Annu Rev Nutr. 2007;27:347–62. PubMed Europe PMC Scholia
  98. Papp LV, Lu J, Holmgren A, Khanna KK. From selenium to selenoproteins: synthesis, identity, and their role in human health. Antioxid Redox Signal. 2007 Jul;9(7):775–806. PubMed Europe PMC Scholia
  99. Karpe F, Bickerton AS, Hodson L, Fielding BA, Tan GD, Frayn KN. Removal of triacylglycerols from chylomicrons and VLDL by capillary beds: the basis of lipoprotein remnant formation. Biochem Soc Trans. 2007 Jun;35(Pt 3):472–6. PubMed Europe PMC Scholia
  100. Panee J, Stoytcheva ZR, Liu W, Berry MJ. Selenoprotein H is a redox-sensing high mobility group family DNA-binding protein that up-regulates genes involved in glutathione synthesis and phase II detoxification. J Biol Chem. 2007 Aug 17;282(33):23759–65. PubMed Europe PMC Scholia
  101. Singh S, Madzelan P, Banerjee R. Properties of an unusual heme cofactor in PLP-dependent cystathionine beta-synthase. Nat Prod Rep. 2007 Jun;24(3):631–9. PubMed Europe PMC Scholia
  102. Barth E, Albuszies G, Baumgart K, Matejovic M, Wachter U, Vogt J, et al. Glucose metabolism and catecholamines. Crit Care Med. 2007 Sep;35(9 Suppl):S508-18. PubMed Europe PMC Scholia
  103. Kalpakcioglu B, Senel K. The interrelation of glutathione reductase, catalase, glutathione peroxidase, superoxide dismutase, and glucose-6-phosphate in the pathogenesis of rheumatoid arthritis. Clin Rheumatol. 2008 Feb;27(2):141–5. PubMed Europe PMC Scholia
  104. Molnar J, Garamvolgyi Z, Herold M, Adanyi N, Somogyi A, Rigo J Jr. Serum selenium concentrations correlate significantly with inflammatory biomarker high-sensitive CRP levels in Hungarian gestational diabetic and healthy pregnant women at mid-pregnancy. Biol Trace Elem Res. 2008 Jan;121(1):16–22. PubMed Europe PMC Scholia
  105. Li Y-C, Chiang C-W, Yeh H-C, Hsu P-Y, Whitby FG, Wang L-H, et al. Structures of prostacyclin synthase and its complexes with substrate analog and inhibitor reveal a ligand-specific heme conformation change. J Biol Chem. 2008 Feb 1;283(5):2917–26. PubMed Europe PMC Scholia
  106. Grumolato L, Ghzili H, Montero-Hadjadje M, Gasman S, Lesage J, Tanguy Y, et al. Selenoprotein T is a PACAP-regulated gene involved in intracellular Ca2+ mobilization and neuroendocrine secretion. FASEB J. 2008 Jun;22(6):1756–68. PubMed Europe PMC Scholia
  107. Cipollone F, Cicolini G, Bucci M. Cyclooxygenase and prostaglandin synthases in atherosclerosis: recent insights and future perspectives. Pharmacol Ther. 2008 May;118(2):161–80. PubMed Europe PMC Scholia
  108. Bosschaerts T, Guilliams M, Noel W, Hérin M, Burk RF, Hill KE, et al. Alternatively activated myeloid cells limit pathogenicity associated with African trypanosomiasis through the IL-10 inducible gene selenoprotein P. J Immunol. 2008 May 1;180(9):6168–75. PubMed Europe PMC Scholia
  109. Banning A, Florian S, Deubel S, Thalmann S, Müller-Schmehl K, Jacobasch G, et al. GPx2 counteracts PGE2 production by dampening COX-2 and mPGES-1 expression in human colon cancer cells. Antioxid Redox Signal. 2008 Sep;10(9):1491–500. PubMed Europe PMC Scholia
  110. Zamocky M, Furtmüller PG, Obinger C. Evolution of catalases from bacteria to humans. Antioxid Redox Signal. 2008 Sep;10(9):1527–48. PubMed Europe PMC Scholia
  111. Basu S. F2-isoprostanes in human health and diseases: from molecular mechanisms to clinical implications. Antioxid Redox Signal. 2008 Aug;10(8):1405–34. PubMed Europe PMC Scholia
  112. Schäfer M, Werner S. Oxidative stress in normal and impaired wound repair. Pharmacol Res. 2008 Aug;58(2):165–71. PubMed Europe PMC Scholia
  113. Ho AWY, Wong CK, Lam CWK. Tumor necrosis factor-alpha up-regulates the expression of CCL2 and adhesion molecules of human proximal tubular epithelial cells through MAPK signaling pathways. Immunobiology. 2008;213(7):533–44. PubMed Europe PMC Scholia
  114. Kwak S-E, Kim J-E, Kim D-W, Kwon O-S, Choi S-Y, Kang T-C. Pyridoxine 5’-phosphate oxidase, not pyridoxal kinase, involves in long-term potentiation induction in the rat dentate gyrus. Hippocampus. 2009 Jan;19(1):45–56. PubMed Europe PMC Scholia
  115. Lu J, Holmgren A. Selenoproteins. J Biol Chem. 2009 Jan 9;284(2):723–7. PubMed Europe PMC Scholia
  116. Moreno JJ. New aspects of the role of hydroxyeicosatetraenoic acids in cell growth and cancer development. Biochem Pharmacol. 2009 Jan 1;77(1):1–10. PubMed Europe PMC Scholia
  117. Kamagate A, Dong HH. FoxO1 integrates insulin signaling to VLDL production. Cell Cycle. 2008 Oct;7(20):3162–70. PubMed Europe PMC Scholia
  118. Verrax J, Calderon PB. The controversial place of vitamin C in cancer treatment. Biochem Pharmacol. 2008 Dec 15;76(12):1644–52. PubMed Europe PMC Scholia
  119. Itabe H. Oxidative modification of LDL: its pathological role in atherosclerosis. Clin Rev Allergy Immunol. 2009 Aug;37(1):4–11. PubMed Europe PMC Scholia
  120. Youssef D, El Abbassi A, Jordan RM, Peiris AN. Fructosamine--an underutilized tool in diabetes management: case report and literature review. Tenn Med. 2008 Nov;101(11):31–3. PubMed Europe PMC Scholia
  121. Steinbrenner H, Sies H. Protection against reactive oxygen species by selenoproteins. Biochim Biophys Acta. 2009 Nov;1790(11):1478–85. PubMed Europe PMC Scholia
  122. Huerta C, Borek D, Machius M, Grishin NV, Zhang H. Structure and mechanism of a eukaryotic FMN adenylyltransferase. J Mol Biol. 2009 Jun 5;389(2):388–400. PubMed Europe PMC Scholia
  123. Hoey L, McNulty H, Strain JJ. Studies of biomarker responses to intervention with riboflavin: a systematic review. Am J Clin Nutr. 2009 Jun;89(6):1960S-1980S. PubMed Europe PMC Scholia
  124. Hoey L, Strain JJ, McNulty H. Studies of biomarker responses to intervention with vitamin B-12: a systematic review of randomized controlled trials. Am J Clin Nutr. 2009 Jun;89(6):1981S-1996S. PubMed Europe PMC Scholia
  125. Wu C, Bates SM. Should D-dimer testing be used to predict the risk of recurrence after discontinuation of anticoagulant therapy for a first unprovoked episode of venous thromboembolism? Pol Arch Med Wewn. 2009 Apr;119(4):225–30. PubMed Europe PMC Scholia
  126. Abello N, Kerstjens HAM, Postma DS, Bischoff R. Protein tyrosine nitration: selectivity, physicochemical and biological consequences, denitration, and proteomics methods for the identification of tyrosine-nitrated proteins. J Proteome Res. 2009 Jul;8(7):3222–38. PubMed Europe PMC Scholia
  127. Kim Y-I. Role of the MTHFR polymorphisms in cancer risk modification and treatment. Future Oncol. 2009 May;5(4):523–42. PubMed Europe PMC Scholia
  128. Whanger PD. Selenoprotein expression and function-selenoprotein W. Biochim Biophys Acta. 2009 Nov;1790(11):1448–52. PubMed Europe PMC Scholia
  129. Arbogast S, Beuvin M, Fraysse B, Zhou H, Muntoni F, Ferreiro A. Oxidative stress in SEPN1-related myopathy: from pathophysiology to treatment. Ann Neurol. 2009 Jun;65(6):677–86. PubMed Europe PMC Scholia
  130. Lavie CJ, Milani RV, Mehra MR, Ventura HO. Omega-3 polyunsaturated fatty acids and cardiovascular diseases. J Am Coll Cardiol. 2009 Aug 11;54(7):585–94. PubMed Europe PMC Scholia
  131. Adams RLC, Bird RJ. Review article: Coagulation cascade and therapeutics update: relevance to nephrology. Part 1: Overview of coagulation, thrombophilias and history of anticoagulants. Nephrology (Carlton). 2009 Aug;14(5):462–70. PubMed Europe PMC Scholia
  132. Shchedrina VA, Zhang Y, Labunskyy VM, Hatfield DL, Gladyshev VN. Structure-function relations, physiological roles, and evolution of mammalian ER-resident selenoproteins. Antioxid Redox Signal. 2010 Apr 1;12(7):839–49. PubMed Europe PMC Scholia
  133. Arbogast S, Ferreiro A. Selenoproteins and protection against oxidative stress: selenoprotein N as a novel player at the crossroads of redox signaling and calcium homeostasis. Antioxid Redox Signal. 2010 Apr 1;12(7):893–904. PubMed Europe PMC Scholia
  134. Eklund CM. Proinflammatory cytokines in CRP baseline regulation. Adv Clin Chem. 2009;48:111–36. PubMed Europe PMC Scholia
  135. Joensen AM, Schmidt EB, Dethlefsen C, Johnsen SP, Tjønneland A, Rasmussen LH, et al. Dietary intake of total marine n-3 polyunsaturated fatty acids, eicosapentaenoic acid, docosahexaenoic acid and docosapentaenoic acid and the risk of acute coronary syndrome - a cohort study. Br J Nutr. 2010 Feb;103(4):602–7. PubMed Europe PMC Scholia