Physiological and pathological hypertrophy of the heart (WP1528)

Pathways in physiological and pathological hypertrophy of the heart. Largely based on the article from [https://www.ncbi.nlm.nih.gov/pubmed/11714087 Wang et al, 'Signal transduction in cardiac hypertrophy--dissecting compensatory versus pathological pathways utilizing a transgenic approach.] Hypertrohpy of the heart can be a physiological compensation for exercise, but it can also be a pathological compensation for hypertension and stress. Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP1528 CPTAC Assay Portal]
last edited

Authors

MLevels, Susan, AlexanderPico, MaintBot, Khanspers, Fehrhart, Egonw, AMTan, and Eweitz

Cited In

Organism

Homo sapiens

Communities

Diseases

Annotations

Cell Type Ontology: cardiac muscle cell

Disease Ontology: heart disease

Pathway Ontology: hypertrophic cardiomyopathy pathway

Participants

Label Type Compact Identifier
MKK3 GeneProduct ncbigene:5606
MYEF2 GeneProduct ncbigene:50804
MAPK14 GeneProduct ncbigene:1432
PRKCB GeneProduct ncbigene:5579
LIFR GeneProduct ncbigene:3977
JNK GeneProduct ncbigene:5599
CAMK2D GeneProduct ncbigene:817
CTF1 GeneProduct ncbigene:1489
JUN GeneProduct ncbigene:3725
PPP3CB GeneProduct ncbigene:5532
PKCE GeneProduct ncbigene:5581
RAC1 GeneProduct ncbigene:5879
EDN1 GeneProduct ncbigene:1906
FOS GeneProduct ncbigene:2353
MAPK11 GeneProduct ncbigene:5600
RHOA GeneProduct ncbigene:387
NFAT3 GeneProduct ncbigene:4776
JNK GeneProduct ncbigene:5599
PPP3CA GeneProduct ncbigene:5530
STAT3 GeneProduct ncbigene:6774
PE Metabolite hmdb:HMDB0002182
MAPK14 GeneProduct ncbigene:1432
GATA4 GeneProduct ncbigene:2626
Calcium Metabolite hmdb:HMDB0000464
MAPK1 GeneProduct ncbigene:5594
AGT GeneProduct ncbigene:183
IL6ST GeneProduct ncbigene:3572
CALM1 Protein ncbigene:801

References

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  2. Wollert KC, Chien KR. Cardiotrophin-1 and the role of gp130-dependent signaling pathways in cardiac growth and development. J Mol Med (Berl). 1997 Jul;75(7):492–501. PubMed Europe PMC Scholia
  3. Wang Y, Su B, Sah VP, Brown JH, Han J, Chien KR. Cardiac hypertrophy induced by mitogen-activated protein kinase kinase 7, a specific activator for c-Jun NH2-terminal kinase in ventricular muscle cells. J Biol Chem. 1998 Mar 6;273(10):5423–6. PubMed Europe PMC Scholia
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  13. Bueno OF, De Windt LJ, Tymitz KM, Witt SA, Kimball TR, Klevitsky R, et al. The MEK1-ERK1/2 signaling pathway promotes compensated cardiac hypertrophy in transgenic mice. EMBO J. 2000 Dec 1;19(23):6341–50. PubMed Europe PMC Scholia
  14. Wang Y. Signal transduction in cardiac hypertrophy--dissecting compensatory versus pathological pathways utilizing a transgenic approach. Curr Opin Pharmacol. 2001 Apr;1(2):134–40. PubMed Europe PMC Scholia
  15. Heineke J, Molkentin JD. Regulation of cardiac hypertrophy by intracellular signalling pathways. Nat Rev Mol Cell Biol. 2006 Aug;7(8):589–600. PubMed Europe PMC Scholia