Vitamin B12 metabolism (WP1533)

Vitamin B12 is a water soluble, organic compound and essential nutrient involved in the everyday functioning of the nervous system and the brain. Vitamin B12 is involved in the preservation and regeneration of the myelin shealth - the protective fatty layer that acts as an insulator in nerve axons. Animals store vitamin B12 in liver and muscle and therefore eggs, milk, meat, liver are sources of the vitamin. Problems in metabolism of vitamin B12 lead to "persistent" lack of energy to perform every day tasks. The genes and pathways highlighted above describe several routes through which genes and metabolites involved in B12 metabolism are interconnected. Central B12 metabolism nodes include folate metabolism and the synthesis of the citric acid cycle intermediates and succinyl-CoA, cyanocobalamin into methylcobalamin conversion, tyrosine nitration and riboflavin pathways. Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP1533 CPTAC Assay Portal].
last edited

Authors

Damariz, Khanspers, AlexanderPico, MaintBot, Andra, Egonw, Mkutmon, Asios Olia, Fehrhart, Wpblocked, DeSl, and Eweitz

Cited In

Organism

Homo sapiens

Communities

Annotations

Disease Ontology: pernicious anemia

Pathway Ontology: cobalamin metabolic pathway

Participants

Label Type Compact Identifier
PGE2 Metabolite hmdb:HMDB0001220
Thromboxane B2 Metabolite hmdb:HMDB0003252
MCP1 GeneProduct ncbigene:6347
PGF2a Metabolite hmdb:HMDB0001139
8-Isoprostaglandin F2a Metabolite hmdb:HMDB0005083
NFKB2 GeneProduct ncbigene:4791
Protein tyrosine nitration Pathway None
IF* GeneProduct ncbigene:2694
TCN2* GeneProduct ncbigene:6948
F2-Isoprostane Metabolite wikidata:Q33659470
F2-Isoprostane Metabolite wikidata:Q33659470
Thromboxane B2 Metabolite hmdb:HMDB0003252
Prostaglandin metabolism Pathway None
a-Tocopherol Metabolite hmdb:HMDB0001893
8-Isoprostaglandin F2a Metabolite hmdb:HMDB0005083
MCP1 GeneProduct ncbigene:6347
PGE2 Metabolite hmdb:HMDB0001220
Lipoprotein metabolism Pathway None
Lipid peroxidation Pathway None
PGE1 Metabolite hmdb:HMDB0001442
PGF2a Metabolite hmdb:HMDB0001139
RELA GeneProduct ncbigene:5970
TCN2* GeneProduct ncbigene:6948
DNA Oxidation Pathway None
Thromboxane B2 Metabolite hmdb:HMDB0003252
HC GeneProduct ncbigene:6947
PGE1 Metabolite hmdb:HMDB0001442
Megalin GeneProduct ncbigene:4036
CUBN GeneProduct ncbigene:8029
a-Tocopherol Metabolite hmdb:HMDB0001893
Thromboxane A2 Metabolite hmdb:HMDB0001452
NFKB1 GeneProduct ncbigene:4790
MM-CoA-H Protein eccode:3.1.2.17
CBR Protein eccode:1.16.1.4
MMAB Protein ncbigene:326625
MAT Protein ncbigene:4143
MTR* Protein ncbigene:4548
MCEE Protein ncbigene:84693
MSR* Protein ncbigene:4552
MUT Protein ncbigene:4594
SHMT Protein ncbigene:6472
CBS Protein ncbigene:875
NADH Metabolite hmdb:HMDB0001487
NADP+ Metabolite hmdb:HMDB0000217
NADP+ Metabolite hmdb:HMDB0000217
NADP+ Metabolite hmdb:HMDB0000217
MPO Protein ncbigene:4353
Cysteine Metabolite hmdb:HMDB0000574
PAI-1 Protein ncbigene:5054
tPA Protein ncbigene:5327
PAI-1 Protein ncbigene:5054
tPA Protein ncbigene:5327
PLG Protein ncbigene:5340
Thrombin Protein ncbigene:2147
Thrombin Protein ncbigene:2147
Factor VII Protein ncbigene:2155
Factor VII Protein ncbigene:2155
PLG Protein ncbigene:5340
H2O2 Metabolite hmdb:HMDB0003125
5,10-Methylene-THF Metabolite hmdb:HMDB0001533
Creatinine Metabolite hmdb:HMDB0000562
5-methyl-THF Metabolite hmdb:HMDB0001396
Creatinine Metabolite hmdb:HMDB0000562
5-methyl-THF Metabolite hmdb:HMDB0001396
SOD3 Protein ncbigene:6649
SOD3 Protein ncbigene:6649
CTH Protein ncbigene:1491
THF Metabolite hmdb:HMDB0001846
NADPH Metabolite hmdb:HMDB0000221
NADPH Metabolite hmdb:HMDB0000221
NADPH Metabolite hmdb:HMDB0000221
NAD Metabolite hmdb:HMDB0000902
MTHFR* Protein ncbigene:4524
Homocysteine Metabolite hmdb:HMDB0000742
Homocysteine Metabolite hmdb:HMDB0000742
SOD1 Protein ncbigene:6647
Pyridoxal 5-phosphate Metabolite HMDB
Pyridoxal 5-phosphate Metabolite hmdb:HMDB0001491
Serine Metabolite hmdb:HMDB0000187
Serine Metabolite hmdb:HMDB0000187
LDL Metabolite chebi:39026
ACT Protein ncbigene:12
VLDL-TAG Metabolite chebi:47776
LDLR Protein ncbigene:3949
HDL-C Metabolite chebi:47775
VLDL Metabolite chebi:39027
LDL Metabolite chebi:39026
HDL Metabolite chebi:39025
APOB Protein ncbigene:338
SRB1 Protein ncbigene:949
LDL/APOB Metabolite chebi:39026
APOB Protein ncbigene:338
VLDL/APOB Metabolite chebi:39027
oxLDL Metabolite chebi:60151
LDL-C Metabolite chebi:47774
ACT Protein ncbigene:12
Cholesterol Metabolite hmdb:HMDB0000067
ABCA1 Protein ncbigene:19
SAA4 Protein ncbigene:6291
SAA3 Protein ncbigene:6290
TAG Metabolite chebi:17855
HDL-C Metabolite chebi:47775
APOA1 Protein ncbigene:335
VLDL-TAG Metabolite chebi:47776
oxLDL Metabolite chebi:60151
LDL-C Metabolite chebi:47774
HDL Metabolite chebi:39025
SAA1 Protein ncbigene:6288
TAG Metabolite chebi:17855
HDL/SAA Metabolite chebi:39025
APOE Protein ncbigene:348
APOA1-NO2Tyr Protein ncbigene:335
APOA1 Protein ncbigene:335
VLDL Metabolite chebi:39027
SAA2 Protein ncbigene:6289
Cholesterol Metabolite hmdb:HMDB0000067
HDL/APOA1 Metabolite chebi:39025
Adenosylcobalamin Metabolite hmdb:HMDB0002086
Adenosylcobalamin Metabolite hmdb:HMDB0002086
Methylcob(III)alamin Metabolite hmdb:HMDB0002274
Vitamin B12/Cobalamin Metabolite hmdb:HMDB0002174
Cob(II)alamin Metabolite hmdb:HMDB0006316
Vitamin B12/Cobalamin Metabolite hmdb:HMDB0002174
Cob(I)alamin Metabolite hmdb:HMDB0003429
FAD Metabolite hmdb:HMDB0001248
8-OHdG Metabolite hmdb:HMDB0003333
8-OHdG Metabolite hmdb:HMDB0003333
Methylcob(III)alamin Metabolite hmdb:HMDB0002274
Chlorine Metabolite hmdb:HMDB0000492
vitamin D Metabolite chebi:27300
vitamin D Metabolite chebi:27300
Chlorine Metabolite hmdb:HMDB0000492
Cystathionine Metabolite hmdb:HMDB0000099
SOD2 Protein ncbigene:6648
Zinc Metabolite hmdb:HMDB0015532
Zinc Metabolite hmdb:HMDB0015532
NO Metabolite hmdb:HMDB0003378
NO3- Metabolite hmdb:HMDB0002878
NO2 Metabolite chebi:33101
O3 Metabolite chebi:25812
HOCl Metabolite hmdb:HMDB0001050
HNO2 Metabolite chebi:25567
N2O Metabolite chebi:17045
D-dimer Protein wikidata:Q2162109
TNFa Protein ncbigene:7124
HbA1c Protein wikidata:Q311213
Fibrinogen Protein None
IL1B Protein ncbigene:3553
INSR Protein ncbigene:3643
IL6 Protein ncbigene:3569
IL10 Protein ncbigene:3458
ALB Protein ncbigene:213
INS Protein ncbigene:3630
INS Protein ncbigene:3630
ALB Protein ncbigene:213
Fibrin Metabolite wikidata:Q27205
RANTES Protein ncbigene:6352
IL6 Protein ncbigene:3569
HBA1 Protein ncbigene:3039
D-dimer Protein wikidata:Q2162109
sICAM-1 Protein ncbigene:3383
IL1B Protein ncbigene:3553
IL10 Protein ncbigene:3458
Fibrinogen Protein None
TNFa Protein ncbigene:7124
HBB Protein ncbigene:3043
Fibrin Protein wikidata:Q27205
CRP Protein ncbigene:1401
RANTES Protein ncbigene:6352
HbA1c Protein wikidata:Q311213
Riboflavin Metabolite hmdb:HMDB0000244
Riboflavin Metabolite hmdb:HMDB0000244
O2 Metabolite hmdb:HMDB0002168
S-Adenosylhomocysteine Metabolite hmdb:HMDB0000939
Methionine Metabolite hmdb:HMDB0000696
S-Adenosylhomocysteine Metabolite hmdb:HMDB0000939
S-Adenosylmethionine Metabolite hmdb:HMDB0001185
Succinyl-CoA Metabolite hmdb:HMDB0001022
Methylmalonic acid Metabolite hmdb:HMDB0000202
Cbl/TC Metabolite hmdb:HMDB0002174
Methylmalonic acid Metabolite hmdb:HMDB0000202
L-Methylmalonyl-CoA Metabolite hmdb:HMDB0001269
Cbl/IF Metabolite hmdb:HMDB0002174
Cbl/HC Metabolite hmdb:HMDB0002174
Methionine Metabolite hmdb:HMDB0000696
D-Methylmalonyl-CoA Metabolite hmdb:HMDB0001269
Cbl/TC Metabolite hmdb:HMDB0002174
S-Adenosylmethionine Metabolite hmdb:HMDB0001185
Nitrotyrosine Metabolite hmdb:HMDB0001904
ONOO-ONOOH Metabolite hmdb:HMDB0002179
Fructosamine Metabolite hmdb:HMDB0002030
Fructosamine Metabolite hmdb:HMDB0002030
Glucose Metabolite hmdb:HMDB0000122
Glucose Metabolite hmdb:HMDB0000122
Ascorbic acid Metabolite chebi:29073
Ascorbic acid Metabolite chebi:29073
Ascorbic acid Metabolite chebi:29073
FGA Protein None
FGB Protein None
FGG Protein None

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