Angiogenesis (WP1539)

This pathway is a concise and simplified version of the basic proteins involved in angiogenesis. The proces is regulated by hyopoxia, which results in the transcription of eg. VEGF1, FGF2, PDGFbeta, MMP9, MMP2 and Ang1. These proteins bind to their receptors and by doing this they initiate different pathways that result in vessel formation. Proteins on this pathway have targeted assays available via the [ CPTAC Assay Portal]
last edited


LauraS, Khanspers, AlexanderPico, MaintBot, Toxlab, MartijnVanIersel, Egonw, Zari, MirellaKalafati, and Mkutmon

Cited In


Homo sapiens




Pathway Ontology: signaling pathway pertinent to development regulatory pathway


Label Type Compact Identifier
MAPK1 GeneProduct ensembl:ENSG00000100030
ARNT GeneProduct ncbigene:405
PI3K GeneProduct ncbigene:5290
sTIE2 GeneProduct ncbigene:7010
NOS GeneProduct ensembl:ENSG00000164867
Ang 1 GeneProduct uniprot:Q15389
SMAD1 GeneProduct ensembl:ENSG00000170365
PLCG1 GeneProduct ensembl:ENSG00000124181
MMP9 GeneProduct ensembl:ENSG00000100985
FGF2 GeneProduct ensembl:ENSG00000138685
CBP GeneProduct ncbigene:1387
PDGFB GeneProduct ensembl:ENSG00000100311
Ang 1 GeneProduct uniprot:Q15389
TIE2 GeneProduct ncbigene:7010
p38 MAPK GeneProduct ncbigene:1432
FAK GeneProduct uniprot:Q05397
TIMP3 Protein ensembl:ENSG00000100234
PDGFRA GeneProduct uniprot:P16234
VEGFA GeneProduct uniprot:P15692
HIF1A GeneProduct ncbigene:3091
TIMP2 GeneProduct ensembl:ENSG00000035862
MMP2 GeneProduct ensembl:ENSG00000100985
SRC GeneProduct ensembl:ENSG00000197122
PDGFB GeneProduct ensembl:ENSG00000100311
FLT1 GeneProduct ensembl:ENSG00000102755
VEGFR2 GeneProduct ncbigene:3791
MMP2 GeneProduct ensembl:ENSG00000100985
HIF1A GeneProduct ncbigene:3091
FGFR2 GeneProduct ncbigene:2263
MMP9 GeneProduct ensembl:ENSG00000100985
FGF2 GeneProduct ensembl:ENSG00000138685
AKT1 GeneProduct ensembl:ENSG00000142208
VEGFA GeneProduct uniprot:P15692


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