miRNAs involved in DNA damage response (WP1545)

MicroRNA clusters involved in de DNA damage response. Genes they regulated and genes that regulate them. All genes presented in this pathway can also be found in the pathway "DNA damage response(Homo sapiens)". More info can be found there. Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP1545 CPTAC Assay Portal].
last edited

Authors

J.krumeich, Khanspers, MaintBot, MartijnVanIersel, Andra, Mkutmon, Egonw, and Susan

Cited In

Organism

Homo sapiens

Communities

Annotations

Pathway Ontology: DNA repair pathway microRNA pathway

Participants

Label Type Compact Identifier
hsa-mir-18a GeneProduct ensembl:ENSG00000283815
hsa-miR-223 gene GeneProduct None
hsa-miR-29b-2/29c cluster GeneProduct None
hsa-miR-106b/25 cluster GeneProduct None
hsa-mir-15b/16-2 cluster GeneProduct None
hsa-mir-371 GeneProduct ensembl:ENSG00000199031
E2F1 GeneProduct ncbigene:1869
c-Myc GeneProduct ncbigene:4609
hsa-let-7f GeneProduct ensembl:ENSG00000199072
hsa-miR-222/221 cluster GeneProduct None
ATM GeneProduct ncbigene:472
hsa-mir-542 GeneProduct ensembl:ENSG00000207784
hsa-mir-449c GeneProduct mirbase:MI0003823
hsa-mir-181a-2/181b-2 cluster GeneProduct None
hsa-let-7d GeneProduct ensembl:ENSG00000199133
hsa-mir-106b GeneProduct ensembl:ENSG00000208036
hsa-mir-3074 GeneProduct mirbase:MI0014181
c-Myc GeneProduct ncbigene:4609
hsa-mir-372 GeneProduct ensembl:ENSG00000199095
hsa-mir-424 GeneProduct ensembl:ENSG00000284231
hsa-mir-223 GeneProduct ensembl:ENSG00000284567
hsa-mir-29b-1 GeneProduct ensembl:ENSG00000283797
hsa-mir-210 GeneProduct ensembl:ENSG00000199038
hsa-miR-29b-1/29a cluster GeneProduct None
hsa-mir-24 GeneProduct ensembl:ENSG00000207617
hsa-miR-203 gene GeneProduct None
hsa-miR-330 gene GeneProduct None
hsa-mir-374b GeneProduct ensembl:ENSG00000212027
hsa-mir-450b GeneProduct ensembl:ENSG00000216001
ABL1 GeneProduct ncbigene:25
CDK6 GeneProduct ncbigene:1021
hsa-mir-27b GeneProduct ensembl:ENSG00000207864
CDKN1A GeneProduct ncbigene:1026
hsa-mir-15a/16-1 cluster GeneProduct None
hsa-mir-143 GeneProduct ensembl:ENSG00000284182
hsa-mir-34b/34c cluster GeneProduct None
hsa-miR-424/450b cluster GeneProduct None
CCND1 GeneProduct ncbigene:595
hsa-mir-29c GeneProduct ensembl:ENSG00000284214
hsa-mir-23a GeneProduct ensembl:ENSG00000207980
hsa-mir-15a GeneProduct ensembl:ENSG00000283785
CCNE1 GeneProduct ncbigene:898
hsa-mir-503 GeneProduct ensembl:ENSG00000208005
hsa-mir-143/145 cluster GeneProduct None
hsa-mir-195 GeneProduct ensembl:ENSG00000284112
hsa-let-7a-1/7d cluster GeneProduct None
hsa-mir-450a GeneProduct ensembl:ENSG00000207755
hsa-let-7a GeneProduct ensembl:ENSG00000199165
hsa-mir-16 GeneProduct ensembl:ENSG00000208006
hsa-mir-21 GeneProduct ensembl:ENSG00000284190
hsa-mir-25 GeneProduct ensembl:ENSG00000207547
hsa-mir-181a-1/181b-1 cluster GeneProduct None
hsa-mir-374b/421 cluster GeneProduct None
CDKN1B GeneProduct ncbigene:1027
hsa-mir-221 GeneProduct ensembl:ENSG00000207870
hsa-mir-19a GeneProduct ensembl:ENSG00000284204
hsa-mir-181a GeneProduct ensembl:ENSG00000207759
H2AFX GeneProduct ncbigene:3014
hsa-miR-449c/449a cluster GeneProduct None
hsa-let-7a-3/7b cluster GeneProduct None
hsa-mir-93 GeneProduct ensembl:ENSG00000207757
hsa-mir-29a GeneProduct ensembl:ENSG00000284032
CCND3 GeneProduct ncbigene:896
hsa-mir-181b GeneProduct ensembl:ENSG00000207975
hsa-miR-17/92a-1 cluster GeneProduct None
hsa-mir-100 GeneProduct ensembl:ENSG00000207994
hsa-mir-203 GeneProduct ensembl:ENSG00000207568
hsa-mir-145 GeneProduct ensembl:ENSG00000276365
hsa-mir-34b GeneProduct ensembl:ENSG00000207811
hsa-mir-19b-1 GeneProduct ensembl:ENSG00000284375
CREB1 GeneProduct ncbigene:1385
hsa-let-7b GeneProduct ensembl:ENSG00000284520
hsa-mir-23b/24-1 cluster GeneProduct None
hsa-mir-373 GeneProduct ensembl:ENSG00000199143
hsa-miR-21gene GeneProduct None
hsa-mir-34c GeneProduct ensembl:ENSG00000207562
hsa-miR-195/497 cluster GeneProduct None
hsa-mir-497 GeneProduct ensembl:ENSG00000284027
CDC25A2 GeneProduct ncbigene:993
hsa-mir-222 GeneProduct ensembl:ENSG00000207725
hsa-mir-23a/24-2 cluster GeneProduct None
hsa-mir-421 GeneProduct ensembl:ENSG00000202566
hsa-mir-23b GeneProduct ensembl:ENSG00000207563
CCND1 GeneProduct ncbigene:595
hsa-mir-449a GeneProduct ensembl:ENSG00000198983
hsa-mir-371/373 cluster GeneProduct None
TP53 GeneProduct ncbigene:7157
hsa-mir-27a GeneProduct ensembl:ENSG00000207808
hsa-mir-15b GeneProduct ensembl:ENSG00000207779
hsa-mir-17 GeneProduct ensembl:ENSG00000284536
hsa-mir-20a GeneProduct ensembl:ENSG00000283762
hsa-mir-92a-1 GeneProduct ensembl:ENSG00000283705
E2F1 GeneProduct ncbigene:1869
hsa-mir-449b GeneProduct ensembl:ENSG00000207728
hsa-miR-210 gene GeneProduct None
hsa-let-7a-2/100 cluster GeneProduct None
RAD52 GeneProduct ncbigene:5893
hsa-mir-330 GeneProduct ensembl:ENSG00000284544

References

  1. O’Donnell KA, Wentzel EA, Zeller KI, Dang CV, Mendell JT. c-Myc-regulated microRNAs modulate E2F1 expression. Nature. 2005 Jun 9;435(7043):839–43. PubMed Europe PMC Scholia
  2. Sylvestre Y, De Guire V, Querido E, Mukhopadhyay UK, Bourdeau V, Major F, et al. An E2F/miR-20a autoregulatory feedback loop. J Biol Chem. 2007 Jan 26;282(4):2135–43. PubMed Europe PMC Scholia
  3. Woods K, Thomson JM, Hammond SM. Direct regulation of an oncogenic micro-RNA cluster by E2F transcription factors. J Biol Chem. 2007 Jan 26;282(4):2130–4. PubMed Europe PMC Scholia
  4. Bommer GT, Gerin I, Feng Y, Kaczorowski AJ, Kuick R, Love RE, et al. p53-mediated activation of miRNA34 candidate tumor-suppressor genes. Curr Biol. 2007 Aug 7;17(15):1298–307. PubMed Europe PMC Scholia
  5. Corney DC, Flesken-Nikitin A, Godwin AK, Wang W, Nikitin AY. MicroRNA-34b and MicroRNA-34c are targets of p53 and cooperate in control of cell proliferation and adhesion-independent growth. Cancer Res. 2007 Sep 15;67(18):8433–8. PubMed Europe PMC Scholia
  6. Chang T-C, Yu D, Lee Y-S, Wentzel EA, Arking DE, West KM, et al. Widespread microRNA repression by Myc contributes to tumorigenesis. Nat Genet. 2008 Jan;40(1):43–50. PubMed Europe PMC Scholia
  7. Ivanovska I, Ball AS, Diaz RL, Magnus JF, Kibukawa M, Schelter JM, et al. MicroRNAs in the miR-106b family regulate p21/CDKN1A and promote cell cycle progression. Mol Cell Biol. 2008 Apr;28(7):2167–74. PubMed Europe PMC Scholia
  8. Fornari F, Gramantieri L, Ferracin M, Veronese A, Sabbioni S, Calin GA, et al. MiR-221 controls CDKN1C/p57 and CDKN1B/p27 expression in human hepatocellular carcinoma. Oncogene. 2008 Sep 25;27(43):5651–61. PubMed Europe PMC Scholia
  9. Bueno MJ, Pérez de Castro I, Gómez de Cedrón M, Santos J, Calin GA, Cigudosa JC, et al. Genetic and epigenetic silencing of microRNA-203 enhances ABL1 and BCR-ABL1 oncogene expression. Cancer Cell. 2008 Jun;13(6):496–506. PubMed Europe PMC Scholia
  10. Yu Z, Wang C, Wang M, Li Z, Casimiro MC, Liu M, et al. A cyclin D1/microRNA 17/20 regulatory feedback loop in control of breast cancer cell proliferation. J Cell Biol. 2008 Aug 11;182(3):509–17. PubMed Europe PMC Scholia
  11. Liu Q, Fu H, Sun F, Zhang H, Tie Y, Zhu J, et al. miR-16 family induces cell cycle arrest by regulating multiple cell cycle genes. Nucleic Acids Res. 2008 Sep;36(16):5391–404. PubMed Europe PMC Scholia
  12. Lee S-O, Masyuk T, Splinter P, Banales JM, Masyuk A, Stroope A, et al. MicroRNA15a modulates expression of the cell-cycle regulator Cdc25A and affects hepatic cystogenesis in a rat model of polycystic kidney disease. J Clin Invest. 2008 Nov;118(11):3714–24. PubMed Europe PMC Scholia
  13. Brosh R, Shalgi R, Liran A, Landan G, Korotayev K, Nguyen GH, et al. p53-Repressed miRNAs are involved with E2F in a feed-forward loop promoting proliferation. Mol Syst Biol. 2008;4:229. PubMed Europe PMC Scholia
  14. Crosby ME, Kulshreshtha R, Ivan M, Glazer PM. MicroRNA regulation of DNA repair gene expression in hypoxic stress. Cancer Res. 2009 Feb 1;69(3):1221–9. PubMed Europe PMC Scholia
  15. Sachdeva M, Zhu S, Wu F, Wu H, Walia V, Kumar S, et al. p53 represses c-Myc through induction of the tumor suppressor miR-145. Proc Natl Acad Sci U S A. 2009 Mar 3;106(9):3207–12. PubMed Europe PMC Scholia
  16. Yamakuchi M, Lowenstein CJ. MiR-34, SIRT1 and p53: the feedback loop. Cell Cycle. 2009 Mar 1;8(5):712–5. PubMed Europe PMC Scholia
  17. Pigazzi M, Manara E, Baron E, Basso G. miR-34b targets cyclic AMP-responsive element binding protein in acute myeloid leukemia. Cancer Res. 2009 Mar 15;69(6):2471–8. PubMed Europe PMC Scholia
  18. Cuesta R, Martínez-Sánchez A, Gebauer F. miR-181a regulates cap-dependent translation of p27(kip1) mRNA in myeloid cells. Mol Cell Biol. 2009 May;29(10):2841–51. PubMed Europe PMC Scholia
  19. Lal A, Pan Y, Navarro F, Dykxhoorn DM, Moreau L, Meire E, et al. miR-24-mediated downregulation of H2AX suppresses DNA repair in terminally differentiated blood cells. Nat Struct Mol Biol. 2009 May;16(5):492–8. PubMed Europe PMC Scholia
  20. Pothof J, Verkaik NS, van IJcken W, Wiemer EAC, Ta VTB, van der Horst GTJ, et al. MicroRNA-mediated gene silencing modulates the UV-induced DNA-damage response. EMBO J. 2009 Jul 22;28(14):2090–9. PubMed Europe PMC Scholia
  21. Lee K-H, Chen Y-L, Yeh S-D, Hsiao M, Lin J-T, Goan Y-G, et al. MicroRNA-330 acts as tumor suppressor and induces apoptosis of prostate cancer cells through E2F1-mediated suppression of Akt phosphorylation. Oncogene. 2009 Sep 24;28(38):3360–70. PubMed Europe PMC Scholia
  22. Wang P, Zou F, Zhang X, Li H, Dulak A, Tomko RJ Jr, et al. microRNA-21 negatively regulates Cdc25A and cell cycle progression in colon cancer cells. Cancer Res. 2009 Oct 15;69(20):8157–65. PubMed Europe PMC Scholia
  23. Yang X, Feng M, Jiang X, Wu Z, Li Z, Aau M, et al. miR-449a and miR-449b are direct transcriptional targets of E2F1 and negatively regulate pRb-E2F1 activity through a feedback loop by targeting CDK6 and CDC25A. Genes Dev. 2009 Oct 15;23(20):2388–93. PubMed Europe PMC Scholia
  24. Pineau P, Volinia S, McJunkin K, Marchio A, Battiston C, Terris B, et al. miR-221 overexpression contributes to liver tumorigenesis. Proc Natl Acad Sci U S A. 2010 Jan 5;107(1):264–9. PubMed Europe PMC Scholia
  25. Pulikkan JA, Dengler V, Peramangalam PS, Peer Zada AA, Müller-Tidow C, Bohlander SK, et al. Cell-cycle regulator E2F1 and microRNA-223 comprise an autoregulatory negative feedback loop in acute myeloid leukemia. Blood. 2010 Mar 4;115(9):1768–78. PubMed Europe PMC Scholia
  26. Hu H, Du L, Nagabayashi G, Seeger RC, Gatti RA. ATM is down-regulated by N-Myc-regulated microRNA-421. Proc Natl Acad Sci U S A. 2010 Jan 26;107(4):1506–11. PubMed Europe PMC Scholia
  27. Zhao J-J, Lin J, Lwin T, Yang H, Guo J, Kong W, et al. microRNA expression profile and identification of miR-29 as a prognostic marker and pathogenetic factor by targeting CDK6 in mantle cell lymphoma. Blood. 2010 Apr 1;115(13):2630–9. PubMed Europe PMC Scholia
  28. Quintavalle M, Elia L, Condorelli G, Courtneidge SA. MicroRNA control of podosome formation in vascular smooth muscle cells in vivo and in vitro. J Cell Biol. 2010 Apr 5;189(1):13–22. PubMed Europe PMC Scholia
  29. Bueno MJ, Gómez de Cedrón M, Laresgoiti U, Fernández-Piqueras J, Zubiaga AM, Malumbres M. Multiple E2F-induced microRNAs prevent replicative stress in response to mitogenic signaling. Mol Cell Biol. 2010 Jun;30(12):2983–95. PubMed Europe PMC Scholia
  30. Wong P, Iwasaki M, Somervaille TCP, Ficara F, Carico C, Arnold C, et al. The miR-17-92 microRNA polycistron regulates MLL leukemia stem cell potential by modulating p21 expression. Cancer Res. 2010 May 1;70(9):3833–42. PubMed Europe PMC Scholia