MicroRNAs in cardiomyocyte hypertrophy (WP1560)

This pathway shows the role of microRNAs in the process of cardiac hypertrophy. Converted from the humane pathway. MicroRNA targets were predicted by the TargetScan algorithm, and the predicted interactions are shown in red, dashed lines. MicroRNAs are shown as purple rounded rectangles. It is not sure which WNT and frizzled proteins influence cardiac hypertrophy. Though there are strong indications that WNT3A, WNT5A, frizzled1 and frizzled2 play a role in cardiac hypertrophy. Thus these have been added to the pathway instead of all the WNT and frizzled proteins. Experiments which will shed light on this are still being done.
last edited

Authors

MaintBot, MLevels, Ddigles, AlexanderPico, Laurent, and Eweitz

Cited In

Organism

Mus musculus

Communities

Annotations

Pathway Ontology: hypertrophic cardiomyopathy pathway

Participants

Label Type Compact Identifier
mmu-mir-199a-1 Rna mirbase:MI0000241
mmu-mir-15b Rna mirbase:MI0000140
Wnt3a GeneProduct ncbigene:22416
mmu-mir-103-2 Rna mirbase:MI0000588
Stat3 GeneProduct ncbigene:20848
Mapk3 GeneProduct ncbigene:26417
mmu-mir-15b Rna mirbase:MI0000140
mmu-mir-125b-2 Rna mirbase:MI0000152
mmu-mir-23a Rna mirbase:MI0000571
Lif GeneProduct ncbigene:16878
Lrp5 GeneProduct ncbigene:16973
mmu-mir-23a Rna mirbase:MI0000571
Mylk3 GeneProduct ncbigene:213435
mmu-mir-30e Rna mirbase:MI0000259
mmu-mir-195-1 Rna mirbase:MI0000237
Rcan1 GeneProduct ncbigene:54720
mmu-mir-125b-2 Rna mirbase:MI0000152
mmu-mir-195 Rna mirbase:MI0000237
Prkcb GeneProduct ncbigene:18751
mmu-mir-30e Rna mirbase:MI0000259
mmu-mir-21 Rna mirbase:MI0000569
Prkcb GeneProduct ncbigene:18751
mmu-mir-15b Rna mirbase:MI0000140
mmu-mir-195 Rna mirbase:MI0000237
mmu-mir-15b Rna mirbase:MI0000140
Mapk3 GeneProduct ncbigene:26417
mmu-mir-125b-2 Rna mirbase:MI0000152
mmu-mir-130b Rna mirbase:MI0000408
mmu-mir-103-2 Rna mirbase:MI0000588
mmu-let-7b Rna mirbase:MI0000558
mmu-let-7b Rna mirbase:MI0000558
mmu-mir-30e Rna mirbase:MI0000259
Rac1 GeneProduct ncbigene:19353
Hdac4 GeneProduct ncbigene:208727
Hdac9 GeneProduct ncbigene:79221
Pdpk1 GeneProduct ncbigene:18607
mmu-mir-195 Rna mirbase:MI0000237
Igf1 GeneProduct ncbigene:16000
mmu-mir-199a-2 Rna mirbase:MI0000713
mmu-mir-195 Rna mirbase:MI0000237
Mapk8 GeneProduct ncbigene:26419
Mapk1 GeneProduct ncbigene:26413
mmu-mir-133b Rna mirbase:MI0000821
Chuk GeneProduct ncbigene:12675
mmu-mir-125b-1 Rna mirbase:MI0000725
Cdk7 GeneProduct ncbigene:12572
mmu-mir-199a-1 Rna mirbase:MI0000241
mmu-mir-199a-1 Rna mirbase:MI0000241
Calcium Metabolite hmdb:HMDB0000464
mmu-mir-130b Rna mirbase:MI0000408
mmu-mir-23a Rna mirbase:MI0000571
mmu-mir-195 Rna mirbase:MI0000237
mmu-mir-195 Rna mirbase:MI0000237
mmu-mir-140 Rna mirbase:MI0000165
mmu-mir-133a-1 Rna mirbase:MI0000159
Ctnnb1 GeneProduct ncbigene:12387
mmu-mir-21 Rna mirbase:MI0000569
mmu-mir-15b Rna mirbase:MI0000140
Ikbkg GeneProduct ncbigene:16151
mmu-mir-199a-1 Rna mirbase:MI0000241
Agt GeneProduct ncbigene:11606
mmu-mir-23a Rna mirbase:MI0000571
Dvl1 GeneProduct ncbigene:13542
Nfatc4 GeneProduct ncbigene:73181
mmu-mir-140 Rna mirbase:MI0000165
Gsk3b GeneProduct ncbigene:56637
mmu-mir-199a-2 Rna mirbase:MI0000713
Mapk7 GeneProduct ncbigene:23939
Pik3ca GeneProduct ncbigene:18706
Ctf1 GeneProduct ncbigene:13019
mmu-mir-195 Rna mirbase:MI0000237
mmu-mir-199a-1 Rna mirbase:MI0000241
Map2k2 GeneProduct ncbigene:26396
mmu-mir-208a Rna mirbase:MI0000555
Pik3r1 GeneProduct ncbigene:18708
mmu-mir-27b Rna mirbase:MI0000142
mmu-mir-199a-2 Rna mirbase:MI0000713
Mapk3 GeneProduct ncbigene:26417
Pik3r2 GeneProduct ncbigene:18709
mmu-mir-15b Rna mirbase:MI0000140
mmu-mir-30e Rna mirbase:MI0000259
Map2k4 GeneProduct ncbigene:26398
Nfkb1 GeneProduct ncbigene:18033
mmu-mir-195 Rna mirbase:MI0000237
mmu-mir-133a-2 Rna mirbase:MI0000820
Calcium Metabolite hmdb:HMDB0000464
mmu-mir-27b Rna mirbase:MI0000142
Calmodulin Protein None
mmu-mir-199a-1 Rna mirbase:MI0000241
mmu-mir-195 Rna mirbase:MI0000237
mmu-mir-195 Rna mirbase:MI0000237
mmu-mir-103-1 Rna mirbase:MI0000587
mmu-mir-27b Rna mirbase:MI0000142
CaM Protein ncbigene:12313
mmu-mir-199a-1 Rna mirbase:MI0000241
Igf1r GeneProduct ncbigene:16001
Map3k14 GeneProduct ncbigene:53859
mmu-mir-125b-1 Rna mirbase:MI0000725
mmu-mir-15b Rna mirbase:MI0000140
Hdac7 GeneProduct ncbigene:56233
mmu-mir-27b Rna mirbase:MI0000142
mmu-mir-125b-2 Rna mirbase:MI0000152
mmu-mir-27b Rna mirbase:MI0000142
Cish GeneProduct ncbigene:12700
Nfatc4 GeneProduct ncbigene:73181
mmu-mir-140 Rna mirbase:MI0000165
Hdac4 GeneProduct ncbigene:208727
Nfatc4 GeneProduct ncbigene:73181
mmu-mir-15b Rna mirbase:MI0000140
mmu-mir-30e Rna mirbase:MI0000259
mmu-mir-15b Rna mirbase:MI0000140
Mapk1 GeneProduct ncbigene:26413
mmu-mir-23a Rna mirbase:MI0000571
Rock1 GeneProduct ncbigene:19877
mmu-mir-27b Rna mirbase:MI0000142
mmu-mir-27b Rna mirbase:MI0000142
Pdpk1 GeneProduct ncbigene:18607
mmu-mir-185 Rna mirbase:MI0000227
Cdk9 GeneProduct ncbigene:107951
Prkg1 GeneProduct ncbigene:19091
Pik3cd GeneProduct ncbigene:18707
Plcb2 GeneProduct ncbigene:18796
Ikbke GeneProduct ncbigene:56489
Mapk14 GeneProduct ncbigene:26416
Fgfr2 GeneProduct ncbigene:14183
Mapk3 GeneProduct ncbigene:26417
Mylk GeneProduct ncbigene:107589
mmu-mir-214 Rna mirbase:MI0000698
mmu-mir-27b Rna mirbase:MI0000142
Raf1 GeneProduct ncbigene:110157
mmu-mir-199a-2 Rna mirbase:MI0000713
mmu-mir-208a Rna mirbase:MI0000555
mmu-mir-27b Rna mirbase:MI0000142
mmu-mir-199a-2 Rna mirbase:MI0000713
Edn1 GeneProduct ncbigene:13614
mmu-mir-27b Rna mirbase:MI0000142
mmu-let-7b Rna mirbase:MI0000558
mmu-mir-23a Rna mirbase:MI0000571
mmu-mir-15b Rna mirbase:MI0000140
Hdac9 GeneProduct ncbigene:79221
Ikbkb GeneProduct ncbigene:16150
Hdac7 GeneProduct ncbigene:56233
mmu-mir-133a-1 Rna mirbase:MI0000159
Il6st GeneProduct ncbigene:16195
Fzd2 GeneProduct ncbigene:57265
Lrp6 GeneProduct ncbigene:16974
mmu-mir-199a-2 Rna mirbase:MI0000713
mmu-mir-23a Rna mirbase:MI0000571
mmu-mir-125b-1 Rna mirbase:MI0000725
Map2k7 GeneProduct ncbigene:26400
Pik3cb GeneProduct ncbigene:74769
mmu-mir-15b Rna mirbase:MI0000140
Gsk3b GeneProduct ncbigene:56637
Pik3r3 GeneProduct ncbigene:18710
Nrg1 GeneProduct ncbigene:211323
mmu-mir-199a-2 Rna mirbase:MI0000713
Egf GeneProduct ncbigene:13645
mmu-mir-21 Rna mirbase:MI0000569
Myef2 GeneProduct ncbigene:17876
Mapk8 GeneProduct ncbigene:26419
Ppp3cb GeneProduct ncbigene:19056
mmu-mir-195 Rna mirbase:MI0000237
Akt2 GeneProduct ncbigene:11652
Tgfb1 GeneProduct ncbigene:21803
mmu-mir-125b-1 Rna mirbase:MI0000725
Mtor GeneProduct ncbigene:56717
Fgf2 GeneProduct ncbigene:14173
Map2k3 GeneProduct ncbigene:26397
Agt GeneProduct ncbigene:11606
Mapk4 GeneProduct ncbigene:225724
Cyclic GMP Metabolite hmdb:HMDB0001314
Map2k5 GeneProduct ncbigene:23938
mmu-mir-15b Rna mirbase:MI0000140
Nppa GeneProduct ncbigene:230899
mmu-mir-21 Rna mirbase:MI0000569
Mapk3 GeneProduct ncbigene:26417
sPla2-IIA GeneProduct ncbigene:18780
mmu-mir-23a Rna mirbase:MI0000571
Pik3cg GeneProduct ncbigene:30955
Stat3 GeneProduct ncbigene:20848
Tnf GeneProduct ncbigene:21926
mmu-mir-133b Rna mirbase:MI0000821
Rock2 GeneProduct ncbigene:19878
mmu-mir-30e Rna mirbase:MI0000259
Mapk14 GeneProduct ncbigene:26416
mmu-mir-15b Rna mirbase:MI0000140
mmu-mir-30e Rna mirbase:MI0000259
Map2k1 GeneProduct ncbigene:26395
mmu-mir-208a Rna mirbase:MI0000555
Nppb GeneProduct ncbigene:18158
mmu-mir-133a-2 Rna mirbase:MI0000820
Hdac5 GeneProduct ncbigene:15184
Calcium Metabolite hmdb:HMDB0000464
mmu-let-7b Rna mirbase:MI0000558
Rhoa GeneProduct ncbigene:11848
mmu-mir-30e Rna mirbase:MI0000259
Wnt5a GeneProduct ncbigene:22418
Gata4 GeneProduct ncbigene:14463
mmu-mir-103-1 Rna mirbase:MI0000587
Eif2b5 GeneProduct ncbigene:224045
mmu-let-7b Rna mirbase:MI0000558
mmu-let-7b Rna mirbase:MI0000558
IP3 Metabolite hmdb:HMDB0001498
mmu-mir-185 Rna mirbase:MI0000227
Akt1 GeneProduct ncbigene:11651
Ppp3ca GeneProduct ncbigene:19055
DAG Metabolite hmdb:HMDB0007009
Camk2d GeneProduct ncbigene:108058
mmu-mir-30e Rna mirbase:MI0000259
Map3k7ip1 GeneProduct ncbigene:66513
mmu-mir-133b Rna mirbase:MI0000821
Map2k6 GeneProduct ncbigene:26399
Fzd1 GeneProduct ncbigene:14362
Hdac5 GeneProduct ncbigene:15184
mmu-mir-27b Rna mirbase:MI0000142
Nfkb1 GeneProduct ncbigene:18033
mmu-mir-195 Rna mirbase:MI0000237
mmu-mir-130b Rna mirbase:MI0000408

References

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  3. Heineke J, Molkentin JD. Regulation of cardiac hypertrophy by intracellular signalling pathways. Nat Rev Mol Cell Biol. 2006 Aug;7(8):589–600. PubMed Europe PMC Scholia
  4. Carè A, Catalucci D, Felicetti F, Bonci D, Addario A, Gallo P, et al. MicroRNA-133 controls cardiac hypertrophy. Nat Med. 2007 May;13(5):613–8. PubMed Europe PMC Scholia
  5. Blankesteijn WM, van de Schans VAM, ter Horst P, Smits JFM. The Wnt/frizzled/GSK-3 beta pathway: a novel therapeutic target for cardiac hypertrophy. Trends Pharmacol Sci. 2008 Apr;29(4):175–80. PubMed Europe PMC Scholia
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