Glycolysis and gluconeogenesis (WP157)

Glycolysis is the metabolic pathway that converts glucose C6H12O6, into pyruvate, CH3COCOO− + H+. The free energy released in this process is used to form the ATP and NADH. Gluconeogenesis is a metabolic pathway that results in the generation of glucose from non-carbohydrate carbon substrates such as pyruvate, lactate, glycerol, glucogenic amino acids, and fatty acids. Description adapted from [ Wikipedia].
last edited


Kdahlquist, MaintBot, M.Braymer, MartijnVanIersel, AdrienDefay, Thomas, Christine Chichester, Egonw, Liisa18, AlexanderPico, Gharding, Mkutmon, and Eweitz

Cited In


Mus musculus



Pathway Ontology: glycolysis/gluconeogenesis pathway


Label Type Compact Identifier
Dlat GeneProduct ncbigene:235339
Malate Metabolite hmdb:HMDB0000744
Eno3 GeneProduct ncbigene:13808
Slc2a4 GeneProduct ncbigene:20528
Tpi1 GeneProduct ncbigene:21991
Slc2a2 GeneProduct ncbigene:20526
1,3BP-Glycerate Metabolite hmdb:HMDB0001270
Pyruvate Metabolite hmdb:HMDB0000243
Glucose Metabolite hmdb:HMDB0000122
Eno1 GeneProduct ncbigene:13806
Slc2a5 GeneProduct ncbigene:56485
Ldhal6b GeneProduct ncbigene:106557
Fructose 6P Metabolite hmdb:HMDB0000124
Pgk1 GeneProduct ncbigene:18655
Pyruvate Metabolite hmdb:HMDB0000243
Gpi1 GeneProduct ncbigene:14751
Gck GeneProduct ncbigene:103988
Oxaloacetate Metabolite hmdb:HMDB0000223
P-enolpyruvate Metabolite hmdb:HMDB0000263
Dld GeneProduct ncbigene:13382
Pdha2 GeneProduct ncbigene:18598
Pentose Phosphate Pathway Pathway wikipathways:WP63
Lactate Metabolite chebi:16651
Got2 GeneProduct ncbigene:14719
Fbp2 GeneProduct ncbigene:14120
Gm13882 GeneProduct ncbigene:100043349
3P-Glycerate Metabolite hmdb:HMDB0000807
Slc2a3 GeneProduct ncbigene:20527
Eno2 GeneProduct ncbigene:13807
G6pc GeneProduct ncbigene:14377
Pgam2 GeneProduct ncbigene:56012
Pcx GeneProduct ncbigene:18563
Pck1 GeneProduct ncbigene:18534
TCA cycle Pathway wikipathways:WP434
Oxaloacetate Metabolite hmdb:HMDB0000223
Ldhb GeneProduct ncbigene:16832
Glycogen Metabolism Pathway wikipathways:WP317
Hk3 GeneProduct ncbigene:212032
Acetyl-CoA Metabolite hmdb:HMDB0001206
Ldhc GeneProduct ncbigene:16833
2P-Glycerate Metabolite hmdb:HMDB0000362
Dihydroxyacetone-P Metabolite hmdb:HMDB0001473
Pdhb GeneProduct ncbigene:68263
Triglyceride synthesis Pathway wikipathways:WP386
Pdhx GeneProduct ncbigene:27402
Gapdh GeneProduct ncbigene:14433
Pkm2 GeneProduct ncbigene:18746
MPC1 GeneProduct ncbigene:55951
Aspartate Metabolite hmdb:HMDB0000191
Pkm2 GeneProduct ncbigene:18746
Pfkm GeneProduct ncbigene:18642
Gapdhs GeneProduct ncbigene:14447
Pdha1 GeneProduct ncbigene:18597
Pklr GeneProduct ncbigene:18770
Aldoa GeneProduct ncbigene:11674
Fructose-1,6BP Metabolite hmdb:HMDB0001058
Pgk2 GeneProduct ncbigene:18663
Mdh2 GeneProduct ncbigene:17448
Pfkp GeneProduct ncbigene:56421
Slc2a1 GeneProduct ncbigene:20525
Got1 GeneProduct ncbigene:14718
Malate Metabolite hmdb:HMDB0000744
Glucose-6P Metabolite hmdb:HMDB0001401
Aspartate Metabolite hmdb:HMDB0000191
Glucose Metabolite hmdb:HMDB0000122
Hk1 GeneProduct ncbigene:15275
Glyceraldehyde 3P Metabolite hmdb:HMDB0001112
Aldoc GeneProduct ncbigene:11676
Aldob GeneProduct ncbigene:230163
Pgam1 GeneProduct ncbigene:18648
Hk2 GeneProduct ncbigene:15277
Fbp1 GeneProduct ncbigene:14121
Pfkl GeneProduct ncbigene:18641
Mdh1 GeneProduct ncbigene:17449
Ldha GeneProduct ncbigene:16828
MPC2 GeneProduct ncbigene:70456


  1. Bricker DK, Taylor EB, Schell JC, Orsak T, Boutron A, Chen Y-C, et al. A mitochondrial pyruvate carrier required for pyruvate uptake in yeast, Drosophila, and humans. Science. 2012 Jul 6;337(6090):96–100. PubMed Europe PMC Scholia