Folate-alcohol and cancer pathway hypotheses (WP1589)

As described in Hwang, et al., "The interaction of folate and alcohol consumption has been shown to have an antagonistic effect on the risk of oral cancer. Studies have demonstrated that increased intake of folate decreases the risk of oral cancer, while greater alcohol consumption has an opposite effect." This pathway is a hypothetical model for a causal role for P450 2E1 (CYP2E1) and aldehyde dehydrogenase 1 (ALDH1) in oral cancers, implicating folate (via SAM) and alcohol.
last edited


Whom, Khanspers, MaintBot, AlexanderPico, Egonw, and Eweitz

Cited In


Homo sapiens




Disease Ontology: oral cavity cancer

Pathway Ontology: disease pathway cancer pathway


Label Type Compact Identifier
Nucleotide Synthesis Pathway wikipathways:WP404
ALDH1A1 GeneProduct ncbigene:216
THF Metabolite chebi:20506
MTR GeneProduct ensembl:ENSG00000116984
Cystathionine Metabolite hmdb:HMDB0000099
Methionine Metabolite hmdb:HMDB0000696
SAM Metabolite chemspider:8041295
ALDH1A1 GeneProduct ncbigene:216
C/EBPB GeneProduct ncbigene:1051
Acetaldehyde Metabolite hmdb:HMDB0000990
Acetate Metabolite chebi:30089
CYP2E1 GeneProduct ncbigene:1571
SAH Metabolite chebi:16680
Homocysteine Metabolite hmdb:HMDB0000742
Folate Metabolite chebi:62501
ADH5 GeneProduct ensembl:ENSG00000197894
CREB1 GeneProduct ncbigene:1385
CYP2E1 GeneProduct ncbigene:1571
ALDH1L1 GeneProduct ncbigene:10840
MTHFR GeneProduct ncbigene:4524
5,10-Methylene-THF Metabolite hmdb:HMDB0001533
Ethanol Metabolite hmdb:HMDB0000108
5-Methyl THF Metabolite chebi:15641
ALDH1L1 GeneProduct ncbigene:10840
Cysteine Metabolite hmdb:HMDB0000574
CBS GeneProduct ncbigene:875


  1. Hwang PH, Lian L, Zavras AI. Alcohol intake and folate antagonism via CYP2E1 and ALDH1: effects on oral carcinogenesis. Med Hypotheses. 2012 Feb;78(2):197–202. PubMed Europe PMC Scholia