Small ligand GPCRs (WP161)

G protein–coupled receptors (GPCRs) which are also known as seven-(pass)-transmembrane domain receptors, 7TM receptors, heptahelical receptors, serpentine receptor, and G protein–linked receptors (GPLR), constitute a large protein family of receptors that detect molecules outside the cell and activate internal signal transduction pathways and, ultimately, cellular responses. Coupling with G proteins, they are called seven-transmembrane receptors because they pass through the cell membrane seven times. Source: [–coupled_receptor Wikipedia] These small ligand receptors are part of the Rhodopsin-like family of GPCRs. Source: [ Wikipedia]
last edited


Nsalomonis, MaintBot, M.Ramirez, Ddigles, Egonw, Khanspers, and Eweitz

Cited In


Rattus norvegicus



Pathway Ontology: G protein mediated signaling pathway


Label Type Compact Identifier
Mtnr1a GeneProduct ncbigene:114211
Cnr2 GeneProduct ncbigene:57302
Gq/G11 Pathway Pathway None
Mel-1C GeneProduct None
Ptger1 GeneProduct ncbigene:25637
Ptger2 GeneProduct ncbigene:81752
S1pr2 GeneProduct ncbigene:29415
Gq/G11 Pathway Pathway None
Ptger4 GeneProduct ncbigene:84023
S1pr3 GeneProduct ncbigene:306792
S1pr1 GeneProduct ncbigene:29733
Gi Pathway Pathway None
Cnr1 GeneProduct ncbigene:25248
Tbxa2r GeneProduct ncbigene:24816
Ptafr GeneProduct ncbigene:58949
Lpar1 GeneProduct ncbigene:116744
Ptgir GeneProduct ncbigene:292661
Cannabinoid Metabolite chebi:67194
Melatonin Metabolite chebi:16796
Prostanoids Metabolite chebi:26347
PTGDR GeneProduct ncbigene:498475
Ptger3 GeneProduct ncbigene:24929
S1pr4 GeneProduct ncbigene:314649
Mtnr1b GeneProduct ncbigene:192646
Ptgfr GeneProduct ncbigene:25652