Eicosanoid synthesis (WP167)

In biochemistry, eicosanoids are signaling molecules made by oxidation of twenty-carbon essential fatty acids, (EFAs). They exert complex control over many bodily systems, mainly in inflammation or immunity, and as messengers in the central nervous system. Source: [[wikipedia:Eicosanoid|Wikipedia]]. This pathway has been updated with information from LIPID MAPS>Eicosanoids [https://lipidmaps.org/resources/pathways/vanted.php]. Metabolites and proteins from this pathway are orange coloured and have an rounded rectangle shape (where an rectangle shape indicates that the node only occures in the LIPIDM APS pathway). Reactions occurring in the LIPID MAPS pathways are coloured orange (where a dashed line indicates that the reaction only occures in the LIPID MAPS pathway). Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP167 CPTAC Assay Portal]
last edited

Authors

A.Kwa, MaintBot, Khanspers, Thomas, Carlospirola, AlexanderPico, Christine Chichester, Mkutmon, Egonw, DeSl, Eweitz, and Conroy lipids

Cited In

Organism

Homo sapiens

Communities

Lipids and LIPID MAPS

Annotations

Pathway Ontology: inflammatory response pathway eicosanoid biosynthetic pathway

Cell Type Ontology: epithelial cell

Participants

Label Type Compact Identifier
ALOX5AP GeneProduct ncbigene:241
5-HETE Metabolite cas:70608-72-9
PTGDS GeneProduct ncbigene:5730
5-HPETE Metabolite lipidmaps:LMFA03060108
Prostaglandin H2 Metabolite lipidmaps:LMFA03010010
PTGES2 GeneProduct ncbigene:80142
DPEP1 GeneProduct ncbigene:1800
PTGIS GeneProduct ncbigene:5740
Leukotriene D4 Metabolite lipidmaps:LMFA03020006
PLA2G2A GeneProduct ncbigene:5320
ALOX5 GeneProduct ncbigene:240
PNPLA3 GeneProduct hgnc.symbol:PNPLA3
TBXAS1 GeneProduct ncbigene:6916
GSH peroxidase GeneProduct eccode:1.11.1.9
Thromboxane B2 Metabolite lipidmaps:LMFA03030002
Prostaglandin I2 Metabolite lipidmaps:LMFA03010087
PTGS1 GeneProduct ncbigene:5742
Prostaglandin D2 Metabolite lipidmaps:LMFA03010004
PGE2 9-ketoreduc GeneProduct eccode:1.1.1.189
GGT1 GeneProduct ncbigene:2678
PLA2G6 GeneProduct ncbigene:8398
ALOX15 GeneProduct ncbigene:246
ALOX15B GeneProduct ncbigene:247
Leukotriene A4 Metabolite lipidmaps:LMFA03020023
PTGES GeneProduct ncbigene:9536
ALOX5 GeneProduct ncbigene:240
Prostaglandin F2a Metabolite lipidmaps:LMFA03010002
Leukotriene C4 Metabolite lipidmaps:LMFA03020003
Leukotriene E4 Metabolite lipidmaps:LMFA03020002
LTA4H GeneProduct ncbigene:4048
PTGS2 GeneProduct ncbigene:5743
LTC4S GeneProduct ncbigene:4056
ALOX15 GeneProduct ncbigene:246
12-HETE Metabolite chebi:19138
15-HETE Metabolite chebi:64017
ALOX5AP GeneProduct ncbigene:241
PNPLA8 GeneProduct ncbigene:50640
Thromboxane A2 Metabolite lipidmaps:LMFA03030001
Arachidonic acid Metabolite lipidmaps:LMFA01030001
Per-oxidase GeneProduct eccode:1.11.1.7
ALOX12 GeneProduct ncbigene:239
Leukotriene B4 Metabolite lipidmaps:LMFA03020001
PGD2 Metabolite lipidmaps:LMFA03010004
PGD2 11-ketoreduc GeneProduct eccode:1.1.1.188
12-HPETE Metabolite cas:71030-35-8
15-HPETE Metabolite cas:70981-96-3
Prostaglandin E2 Metabolite lipidmaps:LMFA03010003
15-Dehydro-prostaglandin I2 Metabolite lipidmaps:LMFA03010205
dehydrogenase GeneProduct eccode:1.1.1.231
Thromboxane A3 Metabolite lipidmaps:LMFA03030005
Pla2g5 Protein ncbigene:5322
GP Metabolite chebi:37739
Pla2g6 Protein ncbigene:8398
Pla2g4a Protein ncbigene:5321
Pla2g4b Protein ncbigene:100137049
Ptgs1 Protein ncbigene:5742
Ptgs2 Protein ncbigene:5743
Ptgs1 Protein ncbigene:5742
Ptgs2 Protein ncbigene:5743
PGG2 Metabolite lipidmaps:LMFA03010009
Arachidonic acid Metabolite lipidmaps:LMFA01030001
11-HETE Metabolite lipidmaps:LMFA03060085
ALOX5 GeneProduct ncbigene:240
PGJ2 Metabolite lipidmaps:LMFA03010019
15-deoxy-PGJ2 Metabolite lipidmaps:LMFA03010021
15-deoxy-PGD2 Metabolite lipidmaps:LMFA03010051

References

  1. Korff JM, Jarabak J. Isolation and properties of an NADP+-dependent PGI2-specific 15-hydroxyprostaglandin dehydrogenase from rabbit kidney. Methods Enzymol. 1982;86:152–5. PubMed Europe PMC Scholia
  2. Funk CD. Prostaglandins and leukotrienes: advances in eicosanoid biology. Science. 2001 Nov 30;294(5548):1871–5. PubMed Europe PMC Scholia