Acetylcholine synthesis (WP175)

Acetylcholine is an important neurotransmitter. It can be rapidly released in the synaptic cleft upon activation of the neuron. In the synaptic cleft the compound is degraded rapidly into choline and acetate, this is essential for proper neuronal functioning. Choline and Acetate are taken up into the cytosol and recycled for the next activation.
last edited


A.Kwa, MaintBot, Thomas, Toxlab, Christine Chichester, Khanspers, Mkutmon, and Eweitz

Cited In


Mus musculus



Pathway Ontology: acetylcholine metabolic pathway


Label Type Compact Identifier
Pcyt1a GeneProduct ncbigene:13026
Pdha2 GeneProduct ncbigene:18598
Ache GeneProduct ncbigene:11423
Cytidine diphosphate choline Metabolite hmdb:HMDB0001413
Pdha1 GeneProduct ncbigene:18597
Phosphatidylethanolamine Metabolite hmdb:HMDB0011420
Phosphorylcholine Metabolite hmdb:HMDB0001565
Acetylcholine Metabolite hmdb:HMDB0000895
Choline Metabolite hmdb:HMDB0000097
Glycerophosphocholine Metabolite hmdb:HMDB0000086
Phosphatidylcholine Metabolite hmdb:HMDB0000564
Pyruvate from Glycolysis Metabolite hmdb:HMDB0000243
Acetyl-CoA Metabolite hmdb:HMDB0001206
Pemt GeneProduct ncbigene:18618
Acetate Metabolite hmdb:HMDB0000042
Chka GeneProduct ncbigene:12660
Chat GeneProduct ncbigene:12647
Choline Metabolite hmdb:HMDB0000097


  1. Blusztajn JK, Wurtman RJ. Choline and cholinergic neurons. Science. 1983 Aug 12;221(4611):614–20. PubMed Europe PMC Scholia