Folate metabolism (WP176)

The folic acid-centred micronutrient biological network. The most relevant biochemical processes related to folic acid in the context of metabolism, oxidation and inflammation are represented. Also, the compartmental separation (intracellular vs. plasma) is presented, identifying the folic acid centred plasma metabolome. Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP176 CPTAC Assay Portal]
last edited

Authors

Egoyenechea, MartijnVanIersel, MaintBot, Thomas, Khanspers, Jilldunham, Damariz, Jildau, AlexanderPico, Andra, Egonw, Mkutmon, DeSl, Fehrhart, Youssefwalid, Eweitz, and Marvin M2

Cited In

Organism

Homo sapiens

Communities

Micronutrients

Annotations

Pathway Ontology: folate metabolic pathway

Participants

Label Type Compact Identifier
NFKB1 GeneProduct ncbigene:4790
FOLR1 GeneProduct ncbigene:2348
PGE1 Metabolite hmdb:HMDB0001442
F2-Isoprostane Metabolite wikidata:Q33659470
RELA GeneProduct ncbigene:5970
F2-Isoprostane Metabolite wikidata:Q33659470
MCP1 GeneProduct ncbigene:6347
8-Isoprostaglandin F2a Metabolite hmdb:HMDB0005083
MCP1 GeneProduct ncbigene:6347
p53 GeneProduct ncbigene:7157
FOLR4 GeneProduct ncbigene:390243
PGE1 Metabolite hmdb:HMDB0001442
FOLR3 GeneProduct ncbigene:2352
SLC19A1 GeneProduct ncbigene:6573
PGE2 Metabolite hmdb:HMDB0001220
NFKB2 GeneProduct ncbigene:4791
Thromboxane B2 Metabolite hmdb:HMDB0003252
Thromboxane A2 Metabolite hmdb:HMDB0001452
PGF2a Metabolite hmdb:HMDB0001139
8-Isoprostaglandin F2a Metabolite hmdb:HMDB0005083
FOLR2 GeneProduct ncbigene:2350
PGF2a Metabolite hmdb:HMDB0001139
SLC46A1 GeneProduct ncbigene:113235
PGE2 Metabolite hmdb:HMDB0001220
Thromboxane B2 Metabolite hmdb:HMDB0003252
MTHFD2 Protein ncbigene:10797
MSR* Protein ncbigene:4552
MAT Protein ncbigene:4143
MTHFD1* Protein ncbigene:4522
MTR* Protein ncbigene:4548
AHCY Protein ncbigene:191
SHMT Protein ncbigene:6472
DHFR Protein ncbigene:1719
CBS Protein ncbigene:875
NADP+ Metabolite hmdb:HMDB0000217
NADP+ Metabolite hmdb:HMDB0000217
NADP+ Metabolite hmdb:HMDB0000217
NADP+ Metabolite hmdb:HMDB0000217
NADP+ Metabolite hmdb:HMDB0000217
NADP+ Metabolite hmdb:HMDB0000217
NADP+ Metabolite hmdb:HMDB0000217
MPO Protein ncbigene:4353
NOS Protein uniprot:C9J5P6
Catalase Protein ncbigene:847
MPO Protein ncbigene:4353
Cysteine Metabolite hmdb:HMDB0000574
Cysteine Metabolite hmdb:HMDB0000574
tPA Protein ncbigene:5327
Factor VII Protein ncbigene:2155
PLG Protein ncbigene:5340
tPA Protein ncbigene:5327
Thrombin Protein ncbigene:2147
Thrombin Protein ncbigene:2147
PAI-1 Protein ncbigene:5054
Factor VII Protein ncbigene:2155
PAI-1 Protein ncbigene:5054
PLG Protein ncbigene:5340
GPX 4 Protein ncbigene:2879
H2O2 Metabolite hmdb:HMDB0003125
(11S)-hydroxymethylene-THF Metabolite None
5,10-Methylene-THF Metabolite hmdb:HMDB0001533
5,10-Methenyl-THF Metabolite hmdb:HMDB0001354
5-Formyl-THF Metabolite hmdb:HMDB0001562
10-Formyl-THF Metabolite hmdb:HMDB0000972
(11R)-hydroxymethylene-THF Metabolite None
GAR Metabolite hmdb:HMDB0002022
FGAR Metabolite chebi:18272
Dihydrofolate Metabolite hmdb:HMDB0001056
5-methyl-THF Metabolite hmdb:HMDB0001396
Folate Metabolite chebi:37445
Folate Metabolite chebi:37445
5-methyl-THF Metabolite hmdb:HMDB0001396
SOD3 Protein ncbigene:6649
SOD3 Protein ncbigene:6649
RFK Protein ncbigene:55312
H2O Metabolite hmdb:HMDB0002111
GPX 3 Protein ncbigene:2878
GPX 3 Protein ncbigene:2878
CTH Protein ncbigene:1491
Heme Metabolite hmdb:HMDB0003178
THF Metabolite hmdb:HMDB0001846
NADPH Metabolite hmdb:HMDB0000221
NADPH Metabolite hmdb:HMDB0000221
NADPH Metabolite hmdb:HMDB0000221
NADPH Metabolite hmdb:HMDB0000221
NADPH Metabolite hmdb:HMDB0000221
NADPH Metabolite hmdb:HMDB0000221
NADPH Metabolite hmdb:HMDB0000221
GPX 6 Protein ncbigene:257202
Manganese Metabolite hmdb:HMDB0001333
Manganese Metabolite hmdb:HMDB0001333
Folic acid Metabolite hmdb:HMDB0000121
Folic acid Metabolite hmdb:HMDB0000121
GPX 2 Protein ncbigene:2877
GPX 1 Protein ncbigene:2876
RNS Metabolite chebi:62764
MTHFR* Protein ncbigene:4524
GART Protein ncbigene:2618
MTHFS Protein ncbigene:10588
SHMT Protein ncbigene:6470
Homocysteine Metabolite hmdb:HMDB0000742
Homocysteine Metabolite hmdb:HMDB0000742
SOD1 Protein ncbigene:6647
Pyridoxal 5-phosphate Metabolite HMDB
Pyridoxal 5-phosphate Metabolite hmdb:HMDB0001491
Glycine Metabolite hmdb:HMDB0000123
Glycine Metabolite hmdb:HMDB0000123
L-Arginine Metabolite hmdb:HMDB0000517
Serine Metabolite hmdb:HMDB0000187
LDL Metabolite chebi:39026
ACT Protein ncbigene:12
APOB Protein ncbigene:338
HDL/APOA1 Metabolite chebi:39025
APOA1 Protein ncbigene:335
APOA1 Protein ncbigene:335
LDL Metabolite chebi:39026
TAG Metabolite chebi:17855
APOB Protein ncbigene:338
Cholesterol Metabolite hmdb:HMDB0000067
HDL/SAA Metabolite chebi:39025
HDL Metabolite chebi:39025
SAA1 Protein ncbigene:6288
oxLDL Metabolite chebi:60151
TAG Metabolite chebi:17855
ABCA1 Protein ncbigene:19
SAA4 Protein ncbigene:6291
SAA2 Protein ncbigene:6289
SRB1 Protein ncbigene:949
SAA3 Protein ncbigene:6290
VLDL Metabolite chebi:39027
FMN Metabolite hmdb:HMDB0001520
APOA1-NO2Tyr Protein ncbigene:335
HDL Metabolite chebi:39025
HDL-C Metabolite chebi:47775
HDL-C Metabolite chebi:47775
ACT Protein ncbigene:12
VLDL Metabolite chebi:39027
VLDL-TAG Metabolite chebi:47776
oxLDL Metabolite chebi:60151
Cholesterol Metabolite hmdb:HMDB0000067
VLDL/APOB Metabolite chebi:39027
LDLR Protein ncbigene:3949
VLDL-TAG Metabolite chebi:47776
O2 Metabolite hmdb:HMDB0001377
Cob(I)alamin Metabolite hmdb:HMDB0002174
FAD Metabolite hmdb:HMDB0001248
Cob(I)alamin Metabolite hmdb:HMDB0002174
8-OHdG Metabolite hmdb:HMDB0003333
FAD Metabolite hmdb:HMDB0001248
Cob(II)alamin Metabolite hmdb:HMDB0002174
8-OHdG Metabolite hmdb:HMDB0003333
ADP Metabolite hmdb:HMDB0001341
ADP Metabolite hmdb:HMDB0001341
Magnesium Metabolite hmdb:HMDB0000547
Chlorine Metabolite hmdb:HMDB0000492
Chlorine Metabolite hmdb:HMDB0000492
Magnesium Metabolite hmdb:HMDB0000547
S-nitrosohomocysteine Metabolite pubchem.compound:3035701
Cystathionine Metabolite hmdb:HMDB0000099
SOD2 Protein ncbigene:6648
Serine Metabolite hmdb:HMDB0000187
ATP Metabolite hmdb:HMDB0000538
Zinc Metabolite hmdb:HMDB0015532
Zinc Metabolite hmdb:HMDB0015532
NO Metabolite hmdb:HMDB0003378
HOCl Metabolite hmdb:HMDB0001050
NO Metabolite hmdb:HMDB0003378
O3 Metabolite chebi:25812
NO2 Metabolite chebi:33101
HNO2 Metabolite chebi:25567
IL1B Protein ncbigene:3553
IL2 Protein ncbigene:3558
Fibrinogen Protein wikidata:Q381899
IL1B Protein ncbigene:3553
CRP Protein ncbigene:1401
HBB Protein ncbigene:3043
INSR Protein ncbigene:3643
HBA1 Protein ncbigene:3039
Fibrin Protein wikidata:Q27205
IL10 Protein ncbigene:3458
HbA1c Protein wikidata:Q311213
IL2 Protein ncbigene:3558
IL4 Protein ncbigene:3565
CSF1 Protein ncbigene:1435
ALB Protein ncbigene:213
D-dimer Protein wikidata:Q2162109
INS Protein ncbigene:3630
IFNg Protein ncbigene:3458
Fibrinogen Protein wikidata:Q381899
sICAM-1 Protein ncbigene:3383
IL10 Protein ncbigene:3458
IL4 Protein ncbigene:3565
IFNg Protein ncbigene:3458
TNFa Protein ncbigene:7124
TNFa Protein ncbigene:7124
D-dimer Protein wikidata:Q2162109
Fibrin Metabolite wikidata:Q27205
CSF1 Protein ncbigene:1435
IL6 Protein ncbigene:3569
INS Protein ncbigene:3630
ALB Protein ncbigene:213
HbA1c Protein None
IL6 Protein ncbigene:3569
Riboflavin Metabolite hmdb:HMDB0000244
O2 Metabolite hmdb:HMDB0002168
S-Adenosylmethionine Metabolite hmdb:HMDB0001185
Methionine Metabolite hmdb:HMDB0000696
S-Adenosylhomocysteine Metabolite hmdb:HMDB0000939
Methionine Metabolite hmdb:HMDB0000696
S-Adenosylmethionine Metabolite hmdb:HMDB0001185
S-Adenosylhomocysteine Metabolite hmdb:HMDB0000939
ADP Metabolite hmdb:HMDB0001341
ONOO/ONOOH Metabolite hmdb:HMDB0002179
Nitrotyrosine Metabolite hmdb:HMDB0001904
Nitrotyrosine Metabolite hmdb:HMDB0001904
Tetrahydrobiopterin Metabolite hmdb:HMDB0000027
ATP Metabolite hmdb:HMDB0000538
ATP Metabolite hmdb:HMDB0000538
Glucose Metabolite hmdb:HMDB0000122
Glucose Metabolite hmdb:HMDB0000122
Fructosamine Metabolite hmdb:HMDB0002030
Fructosamine Metabolite hmdb:HMDB0002030
Iron Metabolite hmdb:HMDB0000692
Iron Metabolite hmdb:HMDB0000692
FLAD1 Protein ncbigene:80308
FGA Protein ensembl:ENSG00000171560
FGB Protein ensembl:ENSG00000171564
FGG Protein ensembl:ENSG00000171557

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