Kennedy pathway (WP1771)

The CDP-choline pathway, first identified by Eugene Kennedy in 1956, is the predominant mechanism by which mammalian cells synthesize phosphatidylcholine (PC) for incorporation into membranes or lipid-derived signalling molecules. The CDP-choline pathway represents one half of what is known as the Kennedy pathway. The other half is the CDP-ethanolamine pathway which is responsible for the biosynthesis of the phospholipid product phosphatidylethanolamine (PE). Source: [ Wikipedia]
last edited


MaintBot, Khanspers, Thomas, Ddigles, Egonw, Mkutmon, and DeSl

Cited In


Mus musculus



Pathway Ontology: phospholipid metabolic pathway CDP-choline pathway of phosphatidylcholine biosynthesis


Label Type Compact Identifier
Ethanolamine Metabolite kegg.compound:C00189
SAM Metabolite kegg.compound:C00019
Pisd GeneProduct ncbigene:320951
PPi Metabolite chebi:18361
Cept1 GeneProduct ncbigene:99712
Phosphocholine Metabolite chebi:18132
Sphingolipids Metabolite chebi:26739
Pemt GeneProduct ncbigene:18618
Chkb GeneProduct ncbigene:12651
Phosphatidylserine Metabolite kegg.compound:C02737
Phosphatidylethanolamine Metabolite kegg.compound:C00350
SAH Metabolite kegg.compound:C00021
DAG Metabolite None
CMP Metabolite chebi:17361
ATP Metabolite cas:1927-31-7
Sgpl1 GeneProduct ncbigene:20397
Ptdss1 GeneProduct ncbigene:19210
Chka GeneProduct ncbigene:12660
Pcyt1b GeneProduct ncbigene:236899
Phosphatidylcholines Metabolite cas:8002-43-5
Ethanolamine Metabolite kegg.compound:C00189
L-Serine Metabolite kegg.compound:C00065
ADP Metabolite cas:58-64-0
CDP-choline Metabolite kegg.compound:C00307
L-Serine Metabolite kegg.compound:C00065
Pcyt2 GeneProduct ncbigene:68671
Choline Metabolite kegg.compound:C00114
Etnk1 GeneProduct ncbigene:75320
Pcyt1a GeneProduct ncbigene:13026
Choline Metabolite kegg.compound:C00114
Etnk2 GeneProduct ncbigene:214253
Chpt1 GeneProduct ncbigene:212862
Ptdss2 GeneProduct ncbigene:27388
O-Phosphoethanolamine Metabolite kegg.compound:C00346
AAG Metabolite chebi:73318
CDP-Ethanolamine Metabolite kegg.compound:C00570
CTP Metabolite cas:2056-98-6


  1. Gibellini F, Smith TK. The Kennedy pathway--De novo synthesis of phosphatidylethanolamine and phosphatidylcholine. IUBMB Life. 2010 Jun;62(6):414–28. PubMed Europe PMC Scholia