Integrin-mediated cell adhesion (WP185)

Integrins are receptors that mediate attachment between a cell and the tissues surrounding it, which may be other cells or the extracellular matrix (ECM). They also play a role in cell signaling and thereby define cellular shape, mobility, and regulate the cell cycle. Description reference: [[wikipedia:Integrins|Wikipedia]] Proteins on this pathway have targeted assays available via the [ CPTAC Assay Portal]
last edited

Authors, MaintBot, MartijnVanIersel, Thomas, Khanspers, AlexanderPico, Zari, Mkutmon, and Eweitz

Cited In


Homo sapiens




Pathway Ontology: integrin mediated signaling pathway


Label Type Compact Identifier
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CAPN9 GeneProduct ncbigene:10753
ACTN GeneProduct None
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MIR34C GeneProduct ensembl:ENSG00000207562
ITGB7 GeneProduct ncbigene:3695
MYO-P GeneProduct ensembl:ENSG00000138347
CAPN5 GeneProduct ncbigene:726
ITGAD GeneProduct ncbigene:3681
SEPP1 GeneProduct ncbigene:6414
ROCK1 GeneProduct ncbigene:6093
ITGAV GeneProduct ncbigene:3685
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RAC2 GeneProduct ncbigene:5880
PXN GeneProduct ncbigene:5829
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MAP2K1 GeneProduct ncbigene:5604
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PDPK1 GeneProduct ncbigene:5170
CAPN3 GeneProduct ncbigene:825
SRC GeneProduct ncbigene:6714
DOCK1 GeneProduct ncbigene:1793
VAV3 GeneProduct ncbigene:10451
BRAF GeneProduct ncbigene:673
CAV2 GeneProduct ncbigene:858
ITGAL GeneProduct ncbigene:3683
ARAF GeneProduct ncbigene:369
CAPN11 GeneProduct ncbigene:11131
CAPN10 GeneProduct ncbigene:11132
ITGAX GeneProduct ncbigene:3687
ITGA1 GeneProduct ncbigene:3672
FYN GeneProduct ncbigene:2534
MAPK10 GeneProduct ncbigene:5602
CSK GeneProduct ncbigene:1445
CAV3 GeneProduct ncbigene:859
RHO GeneProduct ncbigene:6010
HRAS GeneProduct ncbigene:3265
MAPK7 GeneProduct ncbigene:5598
CAV1 GeneProduct ncbigene:857
ITGB6 GeneProduct ncbigene:3694
MAPK6 GeneProduct ncbigene:5597
SHC1 GeneProduct ncbigene:6464
ITGB1 GeneProduct ncbigene:3688
CAPN2 GeneProduct ncbigene:824
AKT3 GeneProduct ncbigene:10000
MAP2K2 GeneProduct ncbigene:5605
PIK3R2 GeneProduct ncbigene:5296
ITGA9 GeneProduct ncbigene:3680
TNS1 GeneProduct ncbigene:7145
Phosphatidylinositolsignaling system Pathway None
CAPN7 GeneProduct ncbigene:23473
ITGA5 GeneProduct ncbigene:3678
ITGA10 GeneProduct ncbigene:8515
RAF1 GeneProduct ncbigene:5894
VAV2 GeneProduct ncbigene:7410
CDC42 GeneProduct ncbigene:998
MAP2K5 GeneProduct ncbigene:5607
CAPNS1 GeneProduct ncbigene:826
ITGB2 GeneProduct ncbigene:3689
PAK2 GeneProduct ncbigene:5062
MAP2K3 GeneProduct ncbigene:5606
MAPK1 GeneProduct ncbigene:5594
SORBS1 GeneProduct ncbigene:10580
PI5K GeneProduct None
RAP1B GeneProduct ncbigene:5908
SRC GeneProduct ncbigene:6714
MAP2K6 GeneProduct ncbigene:5608
PAK3 GeneProduct ncbigene:5063
ITGA2 GeneProduct ncbigene:3673
AKT2 GeneProduct ncbigene:208
CAPN1 GeneProduct ncbigene:823
RAC1 GeneProduct ncbigene:5879
ROCK2 GeneProduct ncbigene:9475
GIT2 GeneProduct ncbigene:9815
MYO GeneProduct None
VASP GeneProduct ncbigene:7408
p110 GeneProduct None
ITGA6 GeneProduct ncbigene:3655
PAK1 GeneProduct ncbigene:5058
AKT1 GeneProduct ncbigene:207
GRB2 GeneProduct ncbigene:2885
ITGB5 GeneProduct ncbigene:3693
ITGA8 GeneProduct ncbigene:8516
ITGA11 GeneProduct ncbigene:22801
ARHGEF7 GeneProduct ncbigene:8874
MYLK2 GeneProduct ncbigene:85366
PAK4 GeneProduct ncbigene:10298
MAPK4 GeneProduct ncbigene:5596
MAPK12 GeneProduct ncbigene:6300
RAC3 GeneProduct ncbigene:5881
TLN1 GeneProduct ncbigene:7094
SHC3 GeneProduct ncbigene:53358
PTK2 GeneProduct ncbigene:5747


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