Integrin-mediated cell adhesion (WP185)

Integrins are receptors that mediate attachment between a cell and the tissues surrounding it, which may be other cells or the extracellular matrix (ECM). They also play a role in cell signaling and thereby define cellular shape, mobility, and regulate the cell cycle. Description reference: [[wikipedia:Integrins|Wikipedia]] Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP185 CPTAC Assay Portal]
last edited

Authors

169.230.77.174, MaintBot, MartijnVanIersel, Thomas, Khanspers, AlexanderPico, Zari, Mkutmon, and Eweitz

Cited In

Organism

Homo sapiens

Communities

CPTAC

Annotations

Pathway Ontology: integrin mediated signaling pathway

Participants

Label Type Compact Identifier
ITGA4 GeneProduct ncbigene:3676
CAPN9 GeneProduct ncbigene:10753
ACTN GeneProduct None
ILK GeneProduct ncbigene:3611
PTK2 GeneProduct ncbigene:5747
ITGB3 GeneProduct ncbigene:3690
ITGAE GeneProduct ncbigene:3682
SOS1 GeneProduct ncbigene:6654
ZYX GeneProduct ncbigene:7791
RAP1A GeneProduct ncbigene:5906
ITGAM GeneProduct ncbigene:3684
CRK GeneProduct ncbigene:1398
ITGA7 GeneProduct ncbigene:3679
MIR34C GeneProduct ensembl:ENSG00000207562
ITGB7 GeneProduct ncbigene:3695
MYO-P GeneProduct ensembl:ENSG00000138347
CAPN5 GeneProduct ncbigene:726
ITGAD GeneProduct ncbigene:3681
SEPP1 GeneProduct ncbigene:6414
ROCK1 GeneProduct ncbigene:6093
ITGAV GeneProduct ncbigene:3685
ITGA3 GeneProduct ncbigene:3675
VCL GeneProduct ncbigene:7414
RAPGEF1 GeneProduct ncbigene:2889
ITGA2B GeneProduct ncbigene:3674
CAPN6 GeneProduct ncbigene:827
RAC2 GeneProduct ncbigene:5880
PXN GeneProduct ncbigene:5829
PAK6 GeneProduct ncbigene:56924
MAP2K1 GeneProduct ncbigene:5604
BCAR1 GeneProduct ncbigene:9564
ITGB4 GeneProduct ncbigene:3691
ITGB8 GeneProduct ncbigene:3696
PDPK1 GeneProduct ncbigene:5170
CAPN3 GeneProduct ncbigene:825
SRC GeneProduct ncbigene:6714
DOCK1 GeneProduct ncbigene:1793
VAV3 GeneProduct ncbigene:10451
BRAF GeneProduct ncbigene:673
CAV2 GeneProduct ncbigene:858
ITGAL GeneProduct ncbigene:3683
ARAF GeneProduct ncbigene:369
CAPN11 GeneProduct ncbigene:11131
CAPN10 GeneProduct ncbigene:11132
ITGAX GeneProduct ncbigene:3687
ITGA1 GeneProduct ncbigene:3672
FYN GeneProduct ncbigene:2534
MAPK10 GeneProduct ncbigene:5602
CSK GeneProduct ncbigene:1445
CAV3 GeneProduct ncbigene:859
RHO GeneProduct ncbigene:6010
HRAS GeneProduct ncbigene:3265
MAPK7 GeneProduct ncbigene:5598
CAV1 GeneProduct ncbigene:857
ITGB6 GeneProduct ncbigene:3694
MAPK6 GeneProduct ncbigene:5597
SHC1 GeneProduct ncbigene:6464
ITGB1 GeneProduct ncbigene:3688
CAPN2 GeneProduct ncbigene:824
AKT3 GeneProduct ncbigene:10000
MAP2K2 GeneProduct ncbigene:5605
PIK3R2 GeneProduct ncbigene:5296
ITGA9 GeneProduct ncbigene:3680
TNS1 GeneProduct ncbigene:7145
Phosphatidylinositolsignaling system Pathway None
CAPN7 GeneProduct ncbigene:23473
ITGA5 GeneProduct ncbigene:3678
ITGA10 GeneProduct ncbigene:8515
RAF1 GeneProduct ncbigene:5894
VAV2 GeneProduct ncbigene:7410
CDC42 GeneProduct ncbigene:998
MAP2K5 GeneProduct ncbigene:5607
CAPNS1 GeneProduct ncbigene:826
ITGB2 GeneProduct ncbigene:3689
PAK2 GeneProduct ncbigene:5062
MAP2K3 GeneProduct ncbigene:5606
MAPK1 GeneProduct ncbigene:5594
SORBS1 GeneProduct ncbigene:10580
PI5K GeneProduct None
RAP1B GeneProduct ncbigene:5908
SRC GeneProduct ncbigene:6714
MAP2K6 GeneProduct ncbigene:5608
PAK3 GeneProduct ncbigene:5063
ITGA2 GeneProduct ncbigene:3673
AKT2 GeneProduct ncbigene:208
CAPN1 GeneProduct ncbigene:823
RAC1 GeneProduct ncbigene:5879
ROCK2 GeneProduct ncbigene:9475
GIT2 GeneProduct ncbigene:9815
MYO GeneProduct None
VASP GeneProduct ncbigene:7408
p110 GeneProduct None
ITGA6 GeneProduct ncbigene:3655
PAK1 GeneProduct ncbigene:5058
AKT1 GeneProduct ncbigene:207
GRB2 GeneProduct ncbigene:2885
ITGB5 GeneProduct ncbigene:3693
ITGA8 GeneProduct ncbigene:8516
ITGA11 GeneProduct ncbigene:22801
ARHGEF7 GeneProduct ncbigene:8874
MYLK2 GeneProduct ncbigene:85366
PAK4 GeneProduct ncbigene:10298
MAPK4 GeneProduct ncbigene:5596
MAPK12 GeneProduct ncbigene:6300
RAC3 GeneProduct ncbigene:5881
TLN1 GeneProduct ncbigene:7094
SHC3 GeneProduct ncbigene:53358
PTK2 GeneProduct ncbigene:5747

References

  1. Sepulveda JL, Gkretsi V, Wu C. Assembly and signaling of adhesion complexes. Curr Top Dev Biol. 2005;68:183–225. PubMed Europe PMC Scholia
  2. Hermeking H. The miR-34 family in cancer and apoptosis. Cell Death Differ. 2010 Feb;17(2):193–9. PubMed Europe PMC Scholia