Focal adhesion (WP188)

Cell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the cell-extracellular matrix contact points, specialized structures are formed and termed focal adhesions, where bundles of actin filaments are anchored to transmembrane receptors of the integrin family through a multi-molecular complex of junctional plaque proteins. Some of the constituents of focal adhesions participate in the structural link between membrane receptors and the actin cytoskeleton, while others are signalling molecules, including different protein kinases and phosphatases, their substrates, and various adapter proteins. Integrin signaling is dependent upon the non-receptor tyrosine kinase activities of the FAK and src proteins as well as the adaptor protein functions of FAK, src and Shc to initiate downstream signaling events. These signalling events culminate in reorganization of the actin cytoskeleton; a prerequisite for changes in cell shape and motility, and gene expression. Similar morphological alterations and modulation of gene expression are initiated by the binding of growth factors to their respective receptors, emphasizing the considerable crosstalk between adhesion- and growth factor-mediated signalling.
last edited

Authors

169.230.77.174, MaintBot, Khanspers, Christine Chichester, Fehrhart, Egonw, Mkutmon, and Eweitz

Cited In

Organism

Rattus norvegicus

Communities

Annotations

Pathway Ontology: cell adhesion signaling pathway

Participants

Label Type Compact Identifier
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Spp1 GeneProduct ncbigene:25353
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Tesk2 GeneProduct ncbigene:170908
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Pip5k1c GeneProduct ncbigene:314641
Map2k2 GeneProduct ncbigene:58960
Itgam GeneProduct ncbigene:25021
Ccnd3 GeneProduct ncbigene:25193
Braf GeneProduct ensembl:ENSRNOG00000010957
Erbb2 GeneProduct ncbigene:24337
Actn1 GeneProduct ncbigene:81634
Itgb1 GeneProduct ncbigene:24511
Rhoa GeneProduct ncbigene:117273
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Met GeneProduct ncbigene:24553
Bcl2 GeneProduct ncbigene:24224
Crk1 GeneProduct ncbigene:81649
Figf GeneProduct ncbigene:360457
Mapk12 GeneProduct ncbigene:60352
Lama1 GeneProduct ncbigene:316758
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Col1a2 GeneProduct ncbigene:84352
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Srms GeneProduct ncbigene:296472
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Tln1 GeneProduct ncbigene:313494
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Blk GeneProduct ncbigene:364403
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Rhob GeneProduct ncbigene:64373
Itga3 GeneProduct ncbigene:360606
Itga10 GeneProduct ncbigene:310683
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Itgb5 GeneProduct ensembl:ENSRNOG00000001795
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Elk1 GeneProduct ncbigene:314436
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Braf GeneProduct ensembl:ENSRNOG00000010957
Crk GeneProduct ncbigene:54245
Cav GeneProduct ncbigene:25404
Itga7 GeneProduct ncbigene:81008
Pdgfd GeneProduct ncbigene:66018
Egfr GeneProduct ncbigene:24329
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Akt3 GeneProduct ncbigene:29414
Tnk2 GeneProduct ncbigene:303882
Lama4 GeneProduct ncbigene:309816
Mylk2 GeneProduct ncbigene:117558
Itgae GeneProduct ncbigene:83577
Pdgfc GeneProduct ncbigene:79429
Fgr GeneProduct ncbigene:79113
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Pdgfa GeneProduct ncbigene:25266
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Actb GeneProduct ncbigene:81822
Grb2 GeneProduct ncbigene:81504
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Shc3 GeneProduct ncbigene:114858
Itgb4 GeneProduct ncbigene:3691
Itgad GeneProduct ncbigene:64350
Tnc GeneProduct ncbigene:116640
Pdpk1 GeneProduct ncbigene:81745
Hgf GeneProduct ncbigene:24446
LOC235580 GeneProduct None
Myl6 GeneProduct ncbigene:362816

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