Cholesterol biosynthesis pathway (WP197)

Cholesterol is a waxy steroid metabolite found in the cell membranes and transported in the blood plasma of all animals. It is an essential structural component of mammalian cell membranes, where it is required to establish proper membrane permeability and fluidity. In addition, cholesterol is an important component for the manufacture of bile acids, steroid hormones, and several fat-soluble vitamins. Cholesterol is the principal sterol synthesized by animals, but small quantities are synthesized in other eukaryotes, such as plants and fungi. It is almost completely absent among prokaryotes, which include bacteria. Source: [[wikipedia:Cholesterol|Wikipedia]] Proteins on this pathway have targeted assays available via the [ CPTAC Assay Portal]
last edited


M.Lieberman, MaintBot, Pahles, N.Mantei, Thomas, Samuel Sklar, MartijnVanIersel, Egonw, AlexanderPico, Bart Smeets, AndtheWings, Khanspers, Fehrhart, DeSl, and Eweitz

Cited In


Homo sapiens



Pathway Ontology: cholesterol biosynthetic pathway


Label Type Compact Identifier
NSDHL GeneProduct ncbigene:50814
(S)-2,3-Epoxysqualene Metabolite chebi:15441
Mevalonic acid Metabolite cas:150-97-0
farnesyl pyrophosphate Metabolite cas:13058-04-3
FDPS GeneProduct ncbigene:2224
HMGCS1 GeneProduct ncbigene:3157
SC4MOL GeneProduct ncbigene:6307
Lathosterol Metabolite cas:80-99-9
SQLE GeneProduct ncbigene:6713
Lanosterin Metabolite cas:79-63-0
Mevalonic acid 5-pyrophosphate Metabolite cas:1492-08-6
IDI1 GeneProduct ncbigene:3422
MVD GeneProduct ncbigene:4597
CYP51A1 GeneProduct ncbigene:1595
HMGCR GeneProduct ncbigene:3156
7-Dehydrocholesterol Metabolite cas:434-16-2
DHCR7 GeneProduct ncbigene:1717
isopentenyl pyrophosphate Metabolite cas:358-71-4
PMVK GeneProduct ncbigene:10654
HMG-CoA Metabolite hmdb:HMDB0001375
Geranyl-PP Metabolite cas:6699-20-3
Cholesterol Metabolite cas:57-88-5
Fatty Acid Beta Oxidation Pathway wikipathways:WP143
Mevalonic acid-5P Metabolite cas:73566-35-5
Squalene Metabolite cas:111-02-4
SC5DL GeneProduct ncbigene:6309
FDFT1 GeneProduct ncbigene:2222
LSS GeneProduct ncbigene:4047
MVK GeneProduct ncbigene:4598
Acetyl-CoA Metabolite cas:72-89-9
Dimethylallyl pyrophosphate Metabolite cas:358-72-5
FDPS GeneProduct ncbigene:2224


  1. Porter FD. Malformation syndromes due to inborn errors of cholesterol synthesis. J Clin Invest. 2002 Sep;110(6):715–24. PubMed Europe PMC Scholia