Integrated cancer pathway (WP1971)

This integrated cancer pathway describes the key mechanisms involved in the development of cancer containing the key prognostic markers and pathogenetic factors. Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP1971 CPTAC Assay Portal]
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Authors

Saibrahi, MaintBot, AlexanderPico, MartijnVanIersel, Ddigles, Khanspers, Egonw, Mkutmon, Marvin M2, and Eweitz

Cited In

Organism

Homo sapiens

Communities

Diseases

Annotations

Pathway Ontology: cancer pathway

Disease Ontology: cancer

Participants

Label Type Compact Identifier
ATF1 GeneProduct ensembl:ENSG00000123268
OCT1 Protein ncbigene:5451
p21 Protein ncbigene:1026
CDK4_HUMAN Protein uniprot:P11802
PUMA Protein ncbigene:27113
MIR29C Rna ensembl:ENSG00000284214
CDC25B GeneProduct ensembl:ENSG00000101224
ATM_HUMAN Protein uniprot:Q13315
CASP9_HUMAN Protein uniprot:P55211
DNA-PK Metabolite None
p38 Protein None
CASP8_HUMAN Protein uniprot:Q14790
ATR_HUMAN Protein uniprot:Q13535
CDK2_HUMAN Protein uniprot:P24941
CDC2_HUMAN Protein uniprot:P06493
MIR29B2 Rna ensembl:ENSG00000284203
CDC25A GeneProduct ensembl:ENSG00000164045
P53_HUMAN Protein uniprot:P04637
NOXA1_HUMAN Protein uniprot:Q86UR1
MRE11_HUMAN Protein uniprot:P49959
Cctlp Protein None
ASK1 Protein ncbigene:4217
BARD1_HUMAN Protein uniprot:Q99728
CASP3_HUMAN Protein uniprot:P42574
RB_HUMAN Protein uniprot:P06400
p13K Protein None
BAD_HUMAN Protein uniprot:Q92934
BACH1 GeneProduct ensembl:ENSG00000156273
CHK1_HUMAN Protein uniprot:O14757
PLK1 GeneProduct ensembl:ENSG00000166851
SMAD2_HUMAN Protein uniprot:Q15796
SMAD3_HUMAN Protein uniprot:P84022
p14 Protein None
MSH6_HUMAN Protein uniprot:P52701
AKT1_HUMAN Protein uniprot:P31749
MSH2_HUMAN Protein uniprot:P43246
BCL2_HUMAN Protein uniprot:P10415
MDM2_HUMAN Protein uniprot:Q00987
MIR29B1 Rna ensembl:ENSG00000283797
BRCA1_HUMAN Protein uniprot:P38398
STAT1_HUMAN Protein uniprot:P42224
CHK2_HUMAN Protein uniprot:O96017
BAX_HUMAN Protein uniprot:Q07812
RAD50_HUMAN Protein uniprot:Q92878
MMP1_HUMAN Protein uniprot:P03956
Q8NBS1_HUMAN Protein uniprot:Q8NBS1
JAK1_HUMAN Protein uniprot:P23458
PTEN_HUMAN Protein uniprot:P60484
MIR21 Rna ensembl:ENSG00000284190
p15 Protein ncbigene:1030
p27 Protein ncbigene:1027
BLM_HUMAN Protein uniprot:P54132
BRCA1_HUMAN Protein uniprot:P38398
E2F1_HUMAN Protein uniprot:Q01094
MYC GeneProduct ensembl:ENSG00000136997
Swi/SNF Protein None

References

  1. Meng F, Henson R, Wehbe-Janek H, Ghoshal K, Jacob ST, Patel T. MicroRNA-21 regulates expression of the PTEN tumor suppressor gene in human hepatocellular cancer. Gastroenterology. 2007 Aug;133(2):647–58. PubMed Europe PMC Scholia
  2. Gabriely G, Wurdinger T, Kesari S, Esau CC, Burchard J, Linsley PS, et al. MicroRNA 21 promotes glioma invasion by targeting matrix metalloproteinase regulators. Mol Cell Biol. 2008 Sep;28(17):5369–80. PubMed Europe PMC Scholia
  3. Zhao J-J, Lin J, Lwin T, Yang H, Guo J, Kong W, et al. microRNA expression profile and identification of miR-29 as a prognostic marker and pathogenetic factor by targeting CDK6 in mantle cell lymphoma. Blood. 2010 Apr 1;115(13):2630–9. PubMed Europe PMC Scholia
  4. Wang C, Bian Z, Wei D, Zhang J. miR-29b regulates migration of human breast cancer cells. Mol Cell Biochem. 2011 Jun;352(1–2):197–207. PubMed Europe PMC Scholia