Effects of nitric oxide (WP1995)

NO (Nitric oxide) is an important signalling molecule with vasodilatory and anti-inflammatory effects, indicating a postive role in reducing hypertension and cardiovascular disease. At the same time, NO is also associated with health risks such as increased risk in carcinogenesis, and hypoxia in infants. It has been suggested that NO can also increase mitochondrial efficiency. NO can be formed from L-Arginine through the classic Arginine-NO-Synthase pathway, or it can be formed directly from dietary nitrite by deoxiginated globins.
last edited


MartijnVanIersel, MaintBot, AlexanderPico, Mkutmon, and Eweitz

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Homo sapiens




Pathway Ontology: cardiovascular system homeostasis pathway


Label Type Compact Identifier
NOS3 (endothelial) GeneProduct ncbigene:4846
Nitric oxide Metabolite hmdb:HMDB0003378
AOX1 Protein ensembl:ENSG00000138356
deoxy-hemoglobin GeneProduct ensembl:ENSG00000206172
deoxy-myoglobin GeneProduct ncbigene:4151
Nitrate Metabolite hmdb:HMDB0002878
NOS1 (neuronal) GeneProduct ncbigene:4842
COX1 GeneProduct ncbigene:4512
NOS2 (inducible) GeneProduct ncbigene:4843
Citrulline Metabolite hmdb:HMDB0000904
VItamin C Metabolite hmdb:HMDB0000044
Nitrite Metabolite hmdb:HMDB0002786
XDH GeneProduct ensembl:ENSG00000158125
L-Arginine Metabolite hmdb:HMDB0000517
Oxygen Metabolite hmdb:HMDB0001377


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