Iron metabolism in placenta (WP2007)

During pregnancy, iron is transported from mother to fetus across the placenta. Iron is essential for many biological processes, including the transfer of oxygen in blood, but it can also be toxic. Elaborate and elegant mechanisms have evolved to make sure that the potential for oxidative damage is minimized. This description of Iron pathway through the placenta, and its regulation is purposed to understand the effect of Iron deficiency or Iron overload of the mother on the fetus. Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP2007 CPTAC Assay Portal]
last edited

Authors

Jcompai, Khanspers, MartijnVanIersel, Evelo, MaintBot, Ddigles, Egonw, and AMTan

Cited In

Organism

Homo sapiens

Communities

Micronutrients

Annotations

Pathway Ontology: iron transport pathway iron homeostasis pathway

Participants

Label Type Compact Identifier
SLC40A1 GeneProduct ensembl:ENSG00000138449
foetal HAMP? Protein ensembl:ENSG00000105697
FeII Metabolite cas:15438-31-0
TF Protein ensembl:ENSG00000091513
IREB2 GeneProduct ensembl:ENSG00000136381
HEPHL1 GeneProduct ensembl:ENSG00000181333
HAMP Protein ensembl:ENSG00000105697
IRP1 GeneProduct ensembl:ENSG00000122729
FeIII Metabolite cas:20074-52-6
TfR1 RNA Rna ensembl:ENSG00000072274
TFR1 Protein ensembl:ENSG00000072274
STEAP3 GeneProduct ensembl:ENSG00000115107
TFR1 Protein ensembl:ENSG00000072274
TF Protein ensembl:ENSG00000091513
TFR1 Protein ensembl:ENSG00000072274
TF Protein ensembl:ENSG00000091513
STEAP3 GeneProduct ensembl:ENSG00000115107
TFR1 Protein ensembl:ENSG00000072274
TF Protein ensembl:ENSG00000091513
STEAP3 GeneProduct ensembl:ENSG00000115107
TFR1 Protein ensembl:ENSG00000072274
TF Protein ensembl:ENSG00000091513
SLC11A2 GeneProduct ensembl:ENSG00000110911
MCOLN1 GeneProduct ensembl:ENSG00000090674
MCOLN1 GeneProduct ensembl:ENSG00000090674
SLC11A2 GeneProduct ensembl:ENSG00000110911
foetal TF Protein ensembl:ENSG00000091513
TFR2 GeneProduct ensembl:ENSG00000106327
TF Protein ensembl:ENSG00000091513
TF Protein ensembl:ENSG00000091513
FTH1RNA Rna ensembl:ENSG00000167996
FeIII Metabolite cas:20074-52-6
FeIII Metabolite cas:20074-52-6
FeIII Metabolite cas:20074-52-6
FeIII Metabolite cas:20074-52-6
FeIII Metabolite cas:20074-52-6
FeIII Metabolite cas:20074-52-6
FeIII Metabolite cas:20074-52-6
FeIII Metabolite cas:20074-52-6
FeIII Metabolite cas:20074-52-6
FeIII Metabolite cas:20074-52-6
FeIII Metabolite cas:20074-52-6
FeIII Metabolite cas:20074-52-6
FeIII Metabolite cas:20074-52-6
FeIII Metabolite cas:20074-52-6
FeIII Metabolite cas:20074-52-6
FeIII Metabolite cas:20074-52-6
FeII Metabolite cas:15438-31-0
FeII Metabolite cas:15438-31-0
FeII Metabolite cas:15438-31-0
FeII Metabolite cas:15438-31-0

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