SREBF and miR33 in cholesterol and lipid homeostasis (WP2011)

This pathway describes transcription factor-microRNA circuits governing cholesterol and lipid homeostasis. It is based on a seminar by Dr. Anders Näär. Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP2011 CPTAC Assay Portal]
last edited

Authors

Samuel Sklar, Khanspers, MaintBot, Lindarieswijk, Mkutmon, and Finterly

Cited In

Organism

Homo sapiens

Communities

Annotations

Pathway Ontology: homeostasis pathway

Participants

Label Type Compact Identifier
SREBF1 GeneProduct ensembl:ENSG00000072310
PPARGC1A GeneProduct ensembl:ENSG00000109819
FASN GeneProduct ncbigene:2194
SIRT6 GeneProduct ensembl:ENSG00000077463
HMGCR GeneProduct ensembl:ENSG00000113161
SIRT1 GeneProduct ensembl:ENSG00000096717
MTOR GeneProduct ensembl:ENSG00000198793
SCD GeneProduct ncbigene:6319
NR1H3 GeneProduct ensembl:ENSG00000025434
PPARA GeneProduct ensembl:ENSG00000186951
MIR33A Rna ensembl:ENSG00000207932
MED15 GeneProduct ensembl:ENSG00000099917
SREBF2 GeneProduct ensembl:ENSG00000198911
MIR33B Rna ensembl:ENSG00000207839
HMGCS1 GeneProduct ensembl:ENSG00000112972
LDLR GeneProduct ensembl:ENSG00000130164
ABCA1 GeneProduct ncbigene:19
PRKAA1 GeneProduct ncbigene:5562

References

  1. Yang F, Vought BW, Satterlee JS, Walker AK, Jim Sun Z-Y, Watts JL, et al. An ARC/Mediator subunit required for SREBP control of cholesterol and lipid homeostasis. Nature. 2006 Aug 10;442(7103):700–4. PubMed Europe PMC Scholia
  2. Rodgers JT, Puigserver P. Receptor feasts on sugar and cholesterol. Nat Med. 2007 Feb;13(2):128–9. PubMed Europe PMC Scholia
  3. Gerhart-Hines Z, Rodgers JT, Bare O, Lerin C, Kim S-H, Mostoslavsky R, et al. Metabolic control of muscle mitochondrial function and fatty acid oxidation through SIRT1/PGC-1alpha. EMBO J. 2007 Apr 4;26(7):1913–23. PubMed Europe PMC Scholia
  4. Kim D, Nguyen MD, Dobbin MM, Fischer A, Sananbenesi F, Rodgers JT, et al. SIRT1 deacetylase protects against neurodegeneration in models for Alzheimer’s disease and amyotrophic lateral sclerosis. EMBO J. 2007 Jul 11;26(13):3169–79. PubMed Europe PMC Scholia
  5. Rodgers JT, Puigserver P. Fasting-dependent glucose and lipid metabolic response through hepatic sirtuin 1. Proc Natl Acad Sci U S A. 2007 Jul 31;104(31):12861–6. PubMed Europe PMC Scholia
  6. Cunningham JT, Rodgers JT, Arlow DH, Vazquez F, Mootha VK, Puigserver P. mTOR controls mitochondrial oxidative function through a YY1-PGC-1alpha transcriptional complex. Nature. 2007 Nov 29;450(7170):736–40. PubMed Europe PMC Scholia
  7. Walker AK, Yang F, Jiang K, Ji J-Y, Watts JL, Purushotham A, et al. Conserved role of SIRT1 orthologs in fasting-dependent inhibition of the lipid/cholesterol regulator SREBP. Genes Dev. 2010 Jul 1;24(13):1403–17. PubMed Europe PMC Scholia
  8. Gerin I, Clerbaux L-A, Haumont O, Lanthier N, Das AK, Burant CF, et al. Expression of miR-33 from an SREBP2 intron inhibits cholesterol export and fatty acid oxidation. J Biol Chem. 2010 Oct 29;285(44):33652–61. PubMed Europe PMC Scholia
  9. Horie T, Ono K, Horiguchi M, Nishi H, Nakamura T, Nagao K, et al. MicroRNA-33 encoded by an intron of sterol regulatory element-binding protein 2 (Srebp2) regulates HDL in vivo. Proc Natl Acad Sci U S A. 2010 Oct 5;107(40):17321–6. PubMed Europe PMC Scholia