Arrhythmogenic right ventricular cardiomyopathy (WP2118)

Arrhythmogenic right ventricular cardiomyopathy (ARVC) is an inherited heart disease that may result in arrhythmia, heart failure, and sudden death. Hallmark pathologies of ARVC include myocyte loss and fibrofatty replacement. Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP2118 CPTAC Assay Portal]
last edited

Authors

Nsalomonis, Khanspers, MaintBot, Christine Chichester, AlexanderPico, Fehrhart, AMTan, Eweitz, and Finterly

Cited In

Organism

Homo sapiens

Communities

Annotations

Disease Ontology: arrhythmogenic right ventricular cardiomyopathy

Pathway Ontology: arrhythmogenic right ventricular cardiomyopathy pathway

Participants

Label Type Compact Identifier
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JUP GeneProduct ncbigene:3728
ACTB GeneProduct ncbigene:60
PKP2 GeneProduct ncbigene:5318
CACNB2 GeneProduct ncbigene:783
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ACTN2 GeneProduct ncbigene:88
JUP GeneProduct ncbigene:3728
ITGA9 GeneProduct ncbigene:3680
CACNA1C GeneProduct ncbigene:775
TCF7L1 GeneProduct ncbigene:83439
CTNNA3 GeneProduct ncbigene:29119
ITGA6 GeneProduct ncbigene:3655
ITGA3 GeneProduct ncbigene:3675
JUP GeneProduct ncbigene:3728
ITGB8 GeneProduct ncbigene:3696
DSP GeneProduct ncbigene:1832
ATP2A2 GeneProduct ncbigene:488
Calcium Metabolite kegg.compound:C00076
CACNG6 GeneProduct ncbigene:59285
ITGA2 GeneProduct ncbigene:3673
DSP GeneProduct ncbigene:1832
ITGA1 GeneProduct ncbigene:3672
DSP GeneProduct ncbigene:1832
ITGB7 GeneProduct ncbigene:3695
ITGAV GeneProduct ncbigene:3685
ITGB5 GeneProduct ncbigene:3693
ITGB3 GeneProduct ncbigene:3690
ACTG1 GeneProduct ncbigene:71
SLC8A1 GeneProduct ncbigene:6546
SGCB GeneProduct ncbigene:6443
ITGA7 GeneProduct ncbigene:3679
SGCD GeneProduct ncbigene:6444
CTNNB1 GeneProduct ncbigene:1499
CACNG8 GeneProduct ncbigene:59283
ITGB4 GeneProduct ncbigene:3691
ITGA2B GeneProduct ncbigene:3674
DSC2 GeneProduct ncbigene:1824
CTNNA3 GeneProduct ncbigene:29119
CACNG4 GeneProduct ncbigene:27092
DSG2 GeneProduct ncbigene:1829
ACTG1 GeneProduct ncbigene:71
PKP2 GeneProduct ncbigene:5318
PKP2 GeneProduct ncbigene:5318
DSG2 GeneProduct ncbigene:1829
CACNB4 GeneProduct ncbigene:785
ITGA11 GeneProduct ncbigene:22801
ACTN1 GeneProduct ncbigene:87
Calcium Metabolite kegg.compound:C00076
DSG2 GeneProduct ncbigene:1829
CDH2 GeneProduct ncbigene:1000
CACNB1 GeneProduct ncbigene:782
CACNG7 GeneProduct ncbigene:59284
JUP GeneProduct ncbigene:3728
ACTN4 GeneProduct ncbigene:81
ITGA8 GeneProduct ncbigene:8516
DSC2 GeneProduct ncbigene:1824
RYR2 GeneProduct ncbigene:6262
JUP GeneProduct ncbigene:3728
LMNA GeneProduct ncbigene:4000
Sodium Metabolite kegg.compound:C01330
CTNNA1 GeneProduct ncbigene:1495
TCF7L2 GeneProduct ncbigene:6934
DSG2 GeneProduct ncbigene:1829
SGCG GeneProduct ncbigene:6445
PKP2 GeneProduct ncbigene:5318
Calcium Metabolite kegg.compound:C00076
CTNNA1 GeneProduct ncbigene:1495
DAG1 GeneProduct ncbigene:1605
ACTB GeneProduct ncbigene:60
ECM-receptor interaction Pathway wikipathways:WP306
Cardiac muscle contraction Pathway wikipathways:WP383
CACNA2D1 GeneProduct ncbigene:781
DSC2 GeneProduct ncbigene:1824
CTNNA2 GeneProduct ncbigene:1496
PKP2 GeneProduct ncbigene:5318
Calcium Metabolite kegg.compound:C00076
CACNA1D GeneProduct ncbigene:776
TCF7 GeneProduct ncbigene:6932
ITGA5 GeneProduct ncbigene:3678
CACNG3 GeneProduct ncbigene:10368
CACNG5 GeneProduct ncbigene:27091
DAG1 GeneProduct ncbigene:1605
ITGA4 GeneProduct ncbigene:3676
EMD GeneProduct ncbigene:2010
CDH2 GeneProduct ncbigene:1000
CTNNA2 GeneProduct ncbigene:1496
CACNG1 GeneProduct ncbigene:786
CACNA1F GeneProduct ncbigene:778
PKP2 GeneProduct ncbigene:5318
JUP GeneProduct ncbigene:3728
CACNA2D3 GeneProduct ncbigene:55799
CACNA1S GeneProduct ncbigene:779
JUP GeneProduct ncbigene:3728
DSC2 GeneProduct ncbigene:1824
CACNA2D4 GeneProduct ncbigene:93589
ACTN3 GeneProduct ncbigene:89
Wnt signaling pathway Pathway wikipathways:WP428
ITGB1 GeneProduct ncbigene:3688
CACNG2 GeneProduct ncbigene:10369
DES GeneProduct ncbigene:1674
LAMA2 GeneProduct ncbigene:3908
ITGA10 GeneProduct ncbigene:8515
CACNA2D2 GeneProduct ncbigene:9254
Gap junction Pathway wikipathways:WP1820
SGCA GeneProduct ncbigene:6442
JUP GeneProduct ncbigene:3728
CACNB3 GeneProduct ncbigene:784
Calcium Metabolite kegg.compound:C00076
Calcium Metabolite kegg.compound:C00076
Calcium Metabolite kegg.compound:C00076
Calcium Metabolite kegg.compound:C00076
Sodium Metabolite kegg.compound:C01330
GJA1 GeneProduct ncbigene:2697
GJA1 GeneProduct ncbigene:2697
GJA1 GeneProduct ncbigene:2697
GJA1 GeneProduct ncbigene:2697
DSP GeneProduct ncbigene:1832
DSP GeneProduct ncbigene:1832
DSP GeneProduct ncbigene:1832
DMD GeneProduct ncbigene:1756
DES GeneProduct ncbigene:1674

References