Endothelin pathways (WP2197)

Endothelin-1 is a bicyclic 21 amino acid peptide, produced primarily in the endothelium. It is a potent stimulus of long-lasting and persistent vasoconstriction. It also has a role as a stimulus of inflammation, oxidative stress and cellular proliferation. Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP2197 CPTAC Assay Portal]
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Authors

Sabinedaemen, MireilleSthijns, Egonw, Khanspers, MaintBot, Christine Chichester, AlexanderPico, Mkutmon, L Dupuis, and Eweitz

Cited In

Organism

Homo sapiens

Communities

Renal Genomics Pathways

Annotations

Cell Type Ontology: blood vessel endothelial cell smooth muscle cell

Pathway Ontology: G protein mediated signaling pathway via Galphaq family Ras superfamily mediated signaling pathway G protein mediated signaling pathway via Galphai family G protein mediated signaling pathway via Galphas family endothelin signaling pathway calcium/calmodulin dependent signaling pathway

Disease Ontology: benign essential hypertension hypertension

Participants

Label Type Compact Identifier
RAMP1 GeneProduct ensembl:ENSG00000132329
Y1 GeneProduct ensembl:ENSG00000164128
CGRP GeneProduct ensembl:ENSG00000110680
sGC GeneProduct ensembl:ENSG00000123201
SERCA GeneProduct ensembl:ENSG00000174437
GTP Metabolite hmdb:HMDB0001440
PKA GeneProduct ensembl:ENSG00000178796
EDHF Protein None
L-Arginine Metabolite hmdb:HMDB0000517
AC GeneProduct ensembl:ENSG00000143199
K+ channel Protein None
K+ Metabolite hmdb:HMDB0000586
COX2 GeneProduct ncbigene:4513
a adrenergic receptor GeneProduct ensembl:ENSG00000120907
cGMP Metabolite hmdb:HMDB0001314
K+ Metabolite hmdb:HMDB0000586
NO Metabolite hmdb:HMDB0003378
Ca2+ channel Protein None
ATP Metabolite hmdb:HMDB0001532
cAMP Metabolite hmdb:HMDB0000058
Citrulline Metabolite hmdb:HMDB0000904
Ca2+ channel Protein None
NPY GeneProduct ensembl:ENSG00000122585
Arachidonic acid Metabolite hmdb:HMDB0001043
CRLR GeneProduct ensembl:ENSG00000064989
PGI2 Metabolite wikidata:Q412050
IP1 GeneProduct ensembl:ENSG00000160013
eNOS GeneProduct ensembl:ENSG00000164867
Endothelin 1 GeneProduct ensembl:ENSG00000078401
ECE GeneProduct ensembl:ENSG00000117298
IP3 Metabolite hmdb:HMDB0001059
Cap GeneProduct ensembl:ENSG00000130176
PKC GeneProduct ensembl:ENSG00000154229
GaQ GeneProduct ensembl:ENSG00000060558
MLC GeneProduct ensembl:ENSG00000168530
Big ET1 Protein None
MEK GeneProduct ensembl:ENSG00000169032
EDNRA GeneProduct ensembl:ENSG00000151617
MLCK GeneProduct ensembl:ENSG00000065534
DAG Metabolite hmdb:HMDB0007008
ERK1/2 GeneProduct ensembl:ENSG00000100030
EDNRB GeneProduct ensembl:ENSG00000136160
Furin-like protease Protein None
RAF GeneProduct ensembl:ENSG00000132155
PLCb GeneProduct ensembl:ENSG00000182621
IP3R Protein None
Pre-pro ET1 Rna None
CAD GeneProduct ensembl:ENSG00000084774
Ca2+ Metabolite hmdb:HMDB0000464
CaM GeneProduct ensembl:ENSG00000198668
PIP2 Metabolite hmdb:HMDB0010032
Pre-pro ET1 Protein None
Endothelin 1 GeneProduct ensembl:ENSG00000078401
GbQ GeneProduct ensembl:ENSG00000069966
GgQ GeneProduct ensembl:ENSG00000127588
Ca2+ Metabolite hmdb:HMDB0000464
PMCA Protein None
Ca2+ Metabolite hmdb:HMDB0000464
EDNRB GeneProduct ensembl:ENSG00000136160
GaQ GeneProduct ensembl:ENSG00000060558
GbQ GeneProduct ensembl:ENSG00000069966
GgQ GeneProduct ensembl:ENSG00000127588
PLCb GeneProduct ensembl:ENSG00000182621
PIP2 Metabolite hmdb:HMDB0010032
IP3 Metabolite hmdb:HMDB0001059
DAG Metabolite hmdb:HMDB0007008
Ca2+ Metabolite hmdb:HMDB0000464
Ca2+ Metabolite hmdb:HMDB0000464
Ca2+ channel GeneProduct None
IP3R Protein None
NO Metabolite hmdb:HMDB0003378
PGI2 Metabolite wikidata:Q412050
PKC GeneProduct ensembl:ENSG00000154229
Ca2+ Metabolite hmdb:HMDB0000464
K+ Metabolite hmdb:HMDB0000586
GaS GeneProduct ensembl:ENSG00000087460
GbS GeneProduct ensembl:ENSG00000069966
GgS GeneProduct ensembl:ENSG00000127588
GaQ GeneProduct ensembl:ENSG00000060558
GbQ GeneProduct ensembl:ENSG00000069966
GgQ GeneProduct ensembl:ENSG00000127588
b adrenergic receptor GeneProduct ensembl:ENSG00000043591
GaS GeneProduct ensembl:ENSG00000087460
GbS GeneProduct ensembl:ENSG00000069966
GgS GeneProduct ensembl:ENSG00000127588
K+ Metabolite hmdb:HMDB0000586
CGRP GeneProduct ensembl:ENSG00000110680
CGRP GeneProduct ensembl:ENSG00000110680
GaS GeneProduct ensembl:ENSG00000087460
GbS GeneProduct ensembl:ENSG00000069966
GgS GeneProduct ensembl:ENSG00000127588
K+ Metabolite hmdb:HMDB0000586
K+ Metabolite hmdb:HMDB0000586
NPY GeneProduct ensembl:ENSG00000122585
NPY GeneProduct ensembl:ENSG00000122585
GaI GeneProduct ensembl:ENSG00000127955
GbI GeneProduct ensembl:ENSG00000069966
GgI GeneProduct ensembl:ENSG00000127588
NO Metabolite hmdb:HMDB0003378
NO Metabolite hmdb:HMDB0003378
Ca2+ Metabolite hmdb:HMDB0000464

References