IL-9 signaling pathway (WP22)

IL-9 is a multifunctional cytokine, belonging to a family of cytokines. IL-9 was initially reported as a T cell growth factor in mice. It is now known to target multiple cell types. It plays an important role in the expansion and recruitment of mast cells in response to intestinal nematode infection or during autoimmune encephalomyelitis. It is also known to act on various cell types known to be involved in asthma including T cells, B cells, mast cells, eosinophils, neutrophils, and epithelial cells. IL-9 can promote the expression of TGF-beta in lipopolysaccharide-induced monocytes and macrophages. IL-9 is also known to play important roles in conditions including airway inflammation, EAE and parasitic infections. Mitogen-activated protein kinase pathway is activated transiently by IL-9, which in turn leads to the growth stimulation of hematopoietic cell lines. IL-9 signals through the heterodimeric receptor composed of a specific chain (IL-9R) and a gamma chain (IL2RG), which is shared between IL-2, IL-4, IL-7, IL15 and IL-21. The IL-9R and IL-2RG associates with JAK1 and JAK3 respectively. Receptor engagement results in JAK1- JAK3 cross phosphorylation and activation of the JAK proteins which leads to the activation of Signal transducer and activator of transcription (STAT-1, STAT-3 and STAT-5) and Insulin receptor substrate 1 and 2 (IRS1 and IRS2)/PI3K cascades. IL-9 stimulation also results in the activation of MEK/ERK signaling cascade. Please access this pathway at [http://www.netpath.org/netslim/IL_9_pathway.html NetSlim] database. If you use this pathway, please cite following paper: Kandasamy, K., Mohan, S. S., Raju, R., Keerthikumar, S., Kumar, G. S. S., Venugopal, A. K., Telikicherla, D., Navarro, J. D., Mathivanan, S., Pecquet, C., Gollapudi, S. K., Tattikota, S. G., Mohan, S., Padhukasahasram, H., Subbannayya, Y., Goel, R., Jacob, H. K. C., Zhong, J., Sekhar, R., Nanjappa, V., Balakrishnan, L., Subbaiah, R., Ramachandra, Y. L., Rahiman, B. A., Prasad, T. S. K., Lin, J., Houtman, J. C. D., Desiderio, S., Renauld, J., Constantinescu, S. N., Ohara, O., Hirano, T., Kubo, M., Singh, S., Khatri, P., Draghici, S., Bader, G. D., Sander, C., Leonard, W. J. and Pandey, A. (2010). NetPath: A public resource of curated signal transduction pathways. Genome Biology. 11:R3.
last edited

Authors

A.Pandey, MaintBot, Khanspers, MartijnVanIersel, AlexanderPico, NetPath, Christine Chichester, Mkutmon, Zari, AMTan, L Dupuis, Egonw, and Eweitz

Cited In

Organism

Homo sapiens

Communities

Annotations

Pathway Ontology: interleukin-9 signaling pathway Interleukin mediated signaling pathway

Participants

Label Type Compact Identifier
STAT1 Protein ncbigene:6772
STAT5B Protein ncbigene:6777
MAPK3 Protein ncbigene:5595
GRB2 Protein ncbigene:2885
STAT3 Protein ncbigene:6774
PIK3R2 Protein ncbigene:5296
STAT1 Protein ncbigene:6772
STAT5A Protein ncbigene:6776
STAT1 Protein ncbigene:6772
STAT1 Protein ncbigene:6772
STAT5B Protein ncbigene:6777
IRS1 Protein ncbigene:1025
MAPK1 Protein ncbigene:5594
IL9 Protein ncbigene:3578
JAK3 Protein ncbigene:3718
STAT1 Protein ncbigene:6772
STAT5B Protein ncbigene:6777
IL2RG Protein ncbigene:3561
MAP2K2 Protein ncbigene:5605
PIK3R1 Protein ncbigene:5295
JAK1 Protein ncbigene:3716
STAT3 Protein ncbigene:6774
STAT5B Protein ncbigene:6777
IL9R Protein ncbigene:3581
MAP2K1 Protein ncbigene:5604
STAT1 Protein ncbigene:6772
STAT1 Protein ncbigene:6772

References

  1. Kandasamy K, Mohan SS, Raju R, Keerthikumar S, Kumar GSS, Venugopal AK, et al. NetPath: a public resource of curated signal transduction pathways. Genome Biol. 2010 Jan 12;11(1):R3. PubMed Europe PMC Scholia