Thymic stromal lymphopoietin (TSLP) signaling pathway (WP2203)

Thymic stromal lymphopoietin (TSLP) is an IL-7-like cytokine involved in regulation of a broad spectrum of biological processes. The TSLP receptor complex consists of the IL-7 receptor alpha subunit and its unique TSLPR subunit (gene symbol CRLF2). TSLP can be secreted by epithelial cells upon pathogen stimulation. TSLP can also activate dendritic cells, CD4+ T cells and CD8+ T cells. TSLP not only activate the JAK/STAT pathway but also induce phosphorylation of other signaling molecules including PI3K/Akt, ERK1/2 and JNKs. Aberrant TSLP signaling is implicated in a number of the development of diseases, including asthma, atopic dermatitis, eosinophilic eosophagitis and acute lymphoid leukemia. Description source: [ NetPath] Proteins on this pathway have targeted assays available via the [ CPTAC Assay Portal].
last edited


NetPath, MaintBot, Ddigles, AlexanderPico, Egonw, MirellaKalafati, Khanspers, and Eweitz

Cited In


Homo sapiens



Pathway Ontology: Jak-Stat signaling pathway interleukin-2 family mediated signaling pathway cytokine mediated signaling pathway


Label Type Compact Identifier
MAP2K2 Protein ncbigene:5605
MAPK3 Protein ncbigene:5595
TSLP Protein ncbigene:85480
CRLF2 Protein ncbigene:64109
STAT1 Protein ncbigene:6772
STAT3 Protein ncbigene:6774
STAT4 Protein ncbigene:6775
PIK3CA Protein ncbigene:5290
AKT1 Protein ncbigene:207
MAPK1 Protein ncbigene:5594
MTOR Protein ncbigene:2475
RPS6 Protein ncbigene:6194
PTPN11 Protein ncbigene:5781
JAK2 Protein ncbigene:3717
JAK1 Protein ncbigene:3716
IL7R Protein ncbigene:3575
MAP2K1 Protein ncbigene:5604
MAPK14 Protein ncbigene:1432
EIF4EBP1 Protein ncbigene:1978
NFKBIA Protein ncbigene:4792
RELB Protein ncbigene:5971
RELA Protein ncbigene:5970
NFKB1 Protein ncbigene:4790
NFKB2 Protein ncbigene:4791
MAPK8 Protein ncbigene:5599
RELA Protein ncbigene:5970
RELB Protein ncbigene:5971
NFKB1 Protein ncbigene:4790
NFKB2 Protein ncbigene:4791
TEC Protein ncbigene:7006
PIK42A Protein ncbigene:55361
PI3K Complex eccode:
RPS6 Protein ncbigene:6194
EIF4EBP1 Protein ncbigene:1978
MTORC1 Complex ncbigene:2475
AKT1 Protein ncbigene:207
GAB2 Protein ncbigene:9846
STAT6 Protein ncbigene:6778
SRC Protein ncbigene:6714
STAT5B Protein ncbigene:6777
STAT5A Protein ncbigene:6776
CCL11 Rna ncbigene:6356
STAT5B Protein ncbigene:6777
STAT5A Protein ncbigene:6776
STAT3 Protein ncbigene:6774
MAPK9 Protein ncbigene:5601
MYC Rna ncbigene:4609
IL8 Rna ncbigene:3576
IL2RA Rna ncbigene:3559
IL6 Rna ncbigene:3569
CISH Rna ncbigene:1154
TNFSF4 Rna ncbigene:7292
YES1 Protein ncbigene:7525
LCK Protein ncbigene:3932
BTK Protein ncbigene:695
FES Protein ncbigene:2242
HCK Protein ncbigene:3055
FYN Protein ncbigene:2534
LYN Protein ncbigene:4067