Metastatic brain tumor (WP2249)

Interaction between microRNAs (miRNAs) and abnormal methylation to control metastasis. Tumor growth and metastasis formation through down regulation of their oncogenic targets such as MYC, E2F3 and cyclin-dependent kinase(CDK6). Proteins on this pathway have targeted assays available via the [ CPTAC Assay Portal]
last edited


Devi, MaintBot, Egonw, Khanspers, Elisa, and Mkutmon

Cited In


Homo sapiens




Pathway Ontology: disease pathway

Disease Ontology: disease of cellular proliferation


Label Type Compact Identifier
MIR29A GeneProduct ensembl:ENSG00000284033
MYC GeneProduct ensembl:ENSG00000136997
CDC42 GeneProduct ensembl:ENSG00000070831
E2H2 GeneProduct None
CDK6 GeneProduct ensembl:ENSG00000105810
TP53 GeneProduct ensembl:ENSG00000141510
E2F3 GeneProduct ensembl:ENSG00000112242
MIR34A Rna ensembl:ENSG00000284357
MIR148A Rna ensembl:ENSG00000199085
MIRLET7A1 GeneProduct ensembl:ENSG00000199165
TTP GeneProduct None
P85A_HUMAN Protein uniprot:P27986
MIR148B Rna ensembl:ENSG00000199122
MIR101-1 Rna ensembl:ENSG00000199135
MIR101-2 Rna ensembl:ENSG00000199065
MIR34B Rna ensembl:ENSG00000207811
MIR34C Rna ensembl:ENSG00000207562
MIR29B1 Rna ncbigene:407024
MIR29B2 Rna ncbigene:407025
MIR29C GeneProduct ensembl:ENSG00000284214
MIRLET7A2 Rna ncbigene:406882
MIRLET7A3 GeneProduct ensembl:ENSG00000198986
MIRLET7B Rna ncbigene:406884
MIRLET7C GeneProduct ensembl:ENSG00000199030
MIRLET7D GeneProduct ensembl:ENSG00000199133
MIRLET7E GeneProduct ensembl:ENSG00000198972
MIRLET7F1 GeneProduct ensembl:ENSG00000199072
MIRLET7F2 Rna ncbigene:406889
MIRLET7G GeneProduct ensembl:ENSG00000199150


  1. Park S-Y, Lee JH, Ha M, Nam J-W, Kim VN. miR-29 miRNAs activate p53 by targeting p85 alpha and CDC42. Nat Struct Mol Biol. 2009 Jan;16(1):23–9. PubMed Europe PMC Scholia
  2. Hermeking H. The miR-34 family in cancer and apoptosis. Cell Death Differ. 2010 Feb;17(2):193–9. PubMed Europe PMC Scholia
  3. Christoffersen NR, Shalgi R, Frankel LB, Leucci E, Lees M, Klausen M, et al. p53-independent upregulation of miR-34a during oncogene-induced senescence represses MYC. Cell Death Differ. 2010 Feb;17(2):236–45. PubMed Europe PMC Scholia
  4. Hafner M, Landthaler M, Burger L, Khorshid M, Hausser J, Berninger P, et al. Transcriptome-wide identification of RNA-binding protein and microRNA target sites by PAR-CLIP. Cell. 2010 Apr 2;141(1):129–41. PubMed Europe PMC Scholia