This pathway shows the relationship between BRAF signalling and the development and behavior of pilocytic astrocytoma (PA), normally induced by MAPK pathway activation. BRAF is related in two alternative mechanisms in MAPK activation; first oncogenic fusion between SRGAP3 and RAF1 (highlighted in yellow); second a 3 basepair insertion in BRAF (KIAA1549, again in yellow). This pathway is based on Figure 3" An overview of MAPK pathway alterations in PAs" from [https://doi.org/10.1038/onc.2009.73 Jones et al].

Authors

Devi , Maintenance bot , Daniela Digles , Kristina Hanspers , Denise Slenter , Friederike Ehrhart , Lauren J. Dupuis , and Egon Willighagen

Cited In

Are you planning to include this pathway in your next publication? See How to Cite and add a link here to your paper once it's online.

Organism

Homo sapiens

Communities

Diseases

Annotations

Pathway Ontology: mitogen activated protein kinase signaling pathway glioma pathway

Disease Ontology: pilocytic astrocytoma malignant astrocytoma

Participants

Label	Type	Compact Identifier
GDP	Metabolite	hmdb:HMDB0000960
ERK	GeneProduct	interpro:IPR008350
SOS1	GeneProduct	ensembl:ENSG00000115904
GRB2	GeneProduct	ensembl:ENSG00000177885
RAF1	GeneProduct	ensembl:ENSG00000132155
MEK	GeneProduct	eccode:2.7.12.2
PTPN11	GeneProduct	ensembl:ENSG00000179295
NF1	GeneProduct	ensembl:ENSG00000196712
BRAF	GeneProduct	ensembl:ENSG00000157764
RAS:GTP	Protein	interpro:IPR020849
RTK	Protein	eccode:2.7.10.1
RAS	Protein	pfam:PF00071

References

1. McKay MM, Morrison DK. Integrating signals from RTKs to ERK/MAPK. Oncogene. 2007 May 14;26(22):3113–21. PubMed Europe PMC Scholia
2. Jones DTW, Kocialkowski S, Liu L, Pearson DM, Ichimura K, Collins VP. Oncogenic RAF1 rearrangement and a novel BRAF mutation as alternatives to KIAA1549:BRAF fusion in activating the MAPK pathway in pilocytic astrocytoma. Oncogene. 2009 May 21;28(20):2119–23. PubMed Europe PMC Scholia