Pilocytic astrocytoma (WP2253)

This pathway shows the relationship between BRAF signalling and the development and behavior of pilocytic astrocytoma (PA), normally induced by MAPK pathway activation. BRAF is related in two alternative mechanisms in MAPK activation; first oncogenic fusion between SRGAP3 and RAF1 (highlighted in yellow); second a 3 basepair insertion in BRAF (KIAA1549, again in yellow). This pathway is based on Figure 3" An overview of MAPK pathway alterations in PAs" from [https://doi.org/10.1038/onc.2009.73 Jones et al].
last edited


Devi , Maintenance bot , Daniela Digles , Kristina Hanspers , Denise Slenter , Friederike Ehrhart , Lauren J. Dupuis , and Egon Willighagen

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Homo sapiens




Pathway Ontology: mitogen activated protein kinase signaling pathway glioma pathway

Disease Ontology: pilocytic astrocytoma malignant astrocytoma


Label Type Compact Identifier
GDP Metabolite hmdb:HMDB0000960
ERK GeneProduct interpro:IPR008350
SOS1 GeneProduct ensembl:ENSG00000115904
GRB2 GeneProduct ensembl:ENSG00000177885
RAF1 GeneProduct ensembl:ENSG00000132155
MEK GeneProduct eccode:
PTPN11 GeneProduct ensembl:ENSG00000179295
NF1 GeneProduct ensembl:ENSG00000196712
BRAF GeneProduct ensembl:ENSG00000157764
RAS:GTP Protein interpro:IPR020849
RTK Protein eccode:
RAS Protein pfam:PF00071


  1. McKay MM, Morrison DK. Integrating signals from RTKs to ERK/MAPK. Oncogene. 2007 May 14;26(22):3113–21. PubMed Europe PMC Scholia
  2. Jones DTW, Kocialkowski S, Liu L, Pearson DM, Ichimura K, Collins VP. Oncogenic RAF1 rearrangement and a novel BRAF mutation as alternatives to KIAA1549:BRAF fusion in activating the MAPK pathway in pilocytic astrocytoma. Oncogene. 2009 May 21;28(20):2119–23. PubMed Europe PMC Scholia